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Cinchonine

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Cinchonine Basic information
Cinchonine Chemical Properties
  • Melting point:260-263 °C
  • alpha 224 º (c=0.5, alcohol)
  • Boiling point:436.16°C (rough estimate)
  • Density 1.0863 (rough estimate)
  • refractive index 223 ° (C=0.5, EtOH)
  • storage temp. Store below +30°C.
  • solubility 0.25g/l
  • pka5.85, 9.92(at 25℃)
  • form Micro-Crystalline Powder
  • color White to light beige
  • PH9.0 (0.25g/l, H2O, 20℃)(as aqueous solution)
  • optical activity[α]23/D +228°, c = 0.5 in ethanol
  • Water Solubility Insoluble
  • Sensitive Light Sensitive
  • Merck 14,2287
  • BRN 89689
  • Stability:Stable, but may be light sensitive. Incompatible with strong oxidizing agents.
  • InChIKeyKMPWYEUPVWOPIM-QHQSXHFQSA-N
  • CAS DataBase Reference118-10-5(CAS DataBase Reference)
  • NIST Chemistry ReferenceCinchonine(118-10-5)
  • EPA Substance Registry SystemCinchonan-9-ol, (9S)- (118-10-5)
Safety Information
  • Hazard Codes Xn
  • Risk Statements 20/22-20/21/22
  • Safety Statements 26-36-36/37
  • RIDADR 1544
  • WGK Germany 3
  • RTECS GD3500000
  • 8-34
  • HazardClass 6.1(b)
  • PackingGroup III
  • HS Code 29339900
  • ToxicityLD50 i.p. in rats: 152 mg/kg (Johnson, Poe)
MSDS
Cinchonine Usage And Synthesis
  • Chemical Propertieswhite to light yellow crystal powde
  • Usescardiotonic
  • UsesStereomeric with Cinchonidine (C441925). Antimalarial.
  • UsesCinchonine occurs in most varieties of cinchonabark (Cinchona micrantha and Rubiaceae).It is used as an antimalarial agent.
  • DefinitionChEBI: Cinchonan in which a hydrogen at position 9 is substituted by hydroxy (S configuration). It occurs in the bark of most varieties of Cinchona shrubs, and is frequently used for directing chirality in asymmetric synthesis.
  • Health HazardThe toxic effects from high doses of cinchonineinclude tinnitus, vomiting, diarrhea, andfever. The toxic effects noted in rats were excitement, change in motor activity, andconvulsions. An intraperitoneal LD50 valuein rats is 152 mg/kg.
  • Purification MethodsCrystallise cinchonine from EtOH or diethyl ether. For the N-benzylcinchoninium chloride see above entry in this section. [Rabe Justus Liebigs Ann Chem 365 366, 371 1909, Beilstein 23 III/IV 2819, 2832.]
Cinchonine Preparation Products And Raw materials
Cinchonine(118-10-5)Related Product Information
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