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Phosphatidylethanolamine

Product NamePhosphatidylethanolamine
CAS90989-93-8
MFC9H18NO8P
MW299.214881
EINECS292-752-3
MOL File90989-93-8.mol

Chemical Properties

storage temp.	-20°C
solubility	Chloroform: Soluble
form	solution
color	Light yellow to yellow
InChI	InChI=1S/C9H18NO8P/c1-7(11)15-5-9(18-8(2)12)6-17-19(13,14)16-4-3-10/h9H,3-6,10H2,1-2H3,(H,13,14)
InChIKey	CFWRDBDJAOHXSH-UHFFFAOYSA-N
SMILES	P(=O)(O[H])(OC([H])([H])C([H])([H])N([H])[H])OC([H])([H])C([H])(C([H])([H])OC(C([H])([H])[H])=O)OC(C([H])([H])[H])=O
CAS DataBase Reference	90989-93-8

Safety Information

Hazard Codes	T,Xn
Risk Statements	45-46-23/24/25-36/37/38-48/20/22-22-67-40-36/38-20-63
Safety Statements	53-23-36/37/39-45-26-36/37
RIDADR	UN 2810 6.1/PG 2
WGK Germany	3
F	1-8-10

MSDS

Provider	Language
SigmaAldrich	English

Usage And Synthesis

Chemical Properties

Phosphatidylethanolamine is also known as cerebral lecithin because of its high content in brain tissue. It coexists with lecithin in various tissues and organs of the body, and its structure and physicochemical properties are similar to those of lecithin, except that in cerebral lecithin, it is cholamine that combines with phosphoric acid. This product is a compound glycerophospholipid extracted from the brain and spinal cord of livestock. Slightly yellow amorphous powder; has a special odor. No certain melting point, with spin. Soluble in petroleum ether, chloroform, ether, and methanol, slightly soluble in benzene and carbon tetrachloride, insoluble in water. Easily hygroscopic, easily oxidized to brownish black in air. Amphoteric compound.

Uses

1,2-Diacyl-sn-glycero-3-phosphoethanolamine is the major structural phopholipids in brain.

Biochem/physiol Actions

The major structural phospholipid in brain, comprising 20-25% of total lipid; primarily localized to gray matter.

in vivo

Phosphatidylethanolamine (375 mg/kg; i.p.) significantly inhibits food intake and locomotor activity in mice^[4].
Phosphatidylethanolamine (2 g added to the basal diet containing 8 g of soybean oil; p.o.; dietary administration; ad libitum; 15-18 days) causes a decrease in serum cholesterol, phospholipid, apolipoprotein A-I (apoA-I) and apoE, an increase in high molecular weight apoB, alters the distribution of hepatic phospholipids and the fatty acid composition of serum and hepatic phospholipids in rats^[6].

Animal Model:	Model: Male Wistar rats (weight: 143 g, specific age not mentioned) fed cholesterol-free semipurified diet^[6]
Dosage:	2 g of Phosphatidylethanolamine added to the basal diet containing 8 g of soybean oil
Administration:	Dietary administration, ad libitum, 15-18 days
Result:	Led to a significant decrease in serum cholesteryl ester, phospholipid, apoA-I and apoE, while serum apoB was higher compared to the PC and control groups. Decreased hepatic cholesterol. Altered the relative distribution of phospholipid subclasses in the liver. Altered the fatty acid composition of liver PC and PE. Enhanced the excretion of fecal neutral steroids. Showed higher hepatic HMG-CoA reductase activity.

Phosphatidylethanolamine

Chemical Properties

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Usage And Synthesis

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