In existing technologies, domestic and international literature reports mainly use aniline as a raw material, which is then cyclically synthesized into a quinoline ring with ethyl acetoacetate at 250°C. The resulting ring is then nitrated to obtain 5-nitro-2-methylquinoline, and finally, the target product 5-Aminoquinaldine is obtained under catalytic hydrogenation.
5-Aminoquinaldine is used in organic synthesis and pharmaceutical intermediates.the reaction of 5-aminoquinaldine (IX) with glycerol under the conditions of the skraup reaction gave a 25% yield of 8-methyl-1,7-phenanthroline.
