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Theaflavin 3,3'-digallate

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Theaflavin 3,3'-digallate Basic information
Theaflavin 3,3'-digallate Chemical Properties
  • Melting point:226~230℃
  • Boiling point:1352.6±65.0 °C(Predicted)
  • Density 1.97±0.1 g/cm3(Predicted)
  • form neat
  • pka6.55±0.20(Predicted)
  • InChIKeyZEASWHWETFMWCV-ISBUVJFSSA-N
  • CAS DataBase Reference30462-35-2
Safety Information
  • WGK Germany 3
  • HS Code 29329990
Theaflavin 3,3'-digallate Usage And Synthesis
  • Biological Activities

    Theaflavin-3,3'-digallate (TFDG) is a major polyphenol found in black tea with diverse biological activities. It has antioxidant activity, inhibiting the formation of superoxide radicals, singlet oxygen, hydrogen peroxide, and hydroxyl radicals in vitro (IC50s = 26.7, 0.83, 0.39, and 25.07 µmol/L, respectively).
    It also reduces hydroxyl radical-induced damage to plasmid DNA. TFDG (12.5-50 µM) prevents LPS-induced release of TNF-α, IL-1β, and IL-6, expression of JNK and p38, and nuclear translocation of NF-κB in RAW 264.7 cells [2]. In vivo, TFDG reduces serum levels of TNF-α, IL-1β, and IL-6 and decreases pulmonary edema, pulmonary congestion, and thickening of the alveolar wall in a mouse model of LPS-induced acute lung injury. It also inhibits osteoclast formation, polarization, and osteoclastic bone resorption in vitro and reduces titanium particle-induced bone erosion and the number of mature osteoclasts in mice in a dose-dependent manner. 

Theaflavin 3,3'-digallate(30462-35-2)Related Product Information
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