名称 | Theaflavin 3,3'-digallate |
描述 | Theaflavin 3,3'-digallate (8-Gingerol) , a major polyphenol found in black tea, is an inducer of oxidative stress which has anti-inflammatory and cancer chemopreventive actions, it reduces tumor angiogenesis by downregulating HIF-1αand VEGF. |
体外活性 | 8-Gingerol has antioxidant activity, inhibiting the formation of superoxide radicals, singlet oxygen, hydrogen peroxide, and hydroxyl radicals in vitro (IC50s = 26.7, 0.83, 0.39, and 25.07 μmol/L, respectively) [1]. |
体内活性 | In vivo, Theaflavin 3,3'-digallatereduces serum levels of TNF-α, IL-1β, and IL-6 and decreases pulmonary edema, pulmonary congestion, and thickening of the alveolar wall in a mouse model of LPS-induced acute lung injury. It also inhibits osteoclast formation, polarization, and osteoclastic bone resorption in vitro and reduces titanium particle-induced bone erosion and the number of mature osteoclasts in mice in a dose-dependent manner [3]. |
存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
溶解度 | DMSO : 10 mg/mL (11.51 mM) Ethanol : 10 mg/mL
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关键字 | TF 3 | 0 | TF3 | Theaflavin 3,3'-digallate | ZIKV | Theaflavin 3,3' digallate | ZP10 | HIV | Human immunodeficiency virus | replication | ERK1/2 | p53 | p21 | Akt | U87 | ZP 10 | MAPK | Virus Protease | translation | gp41 | Inhibitor | NF-κB | Theaflavin 3,3'digallate | NS3 | Herpes simplex virus | NS2B-3 | inhibit | HSV | ZP-10 | TF-3 |
相关产品 | Stavudine | 5-Fluorouracil | Emtricitabine | Phenytoin sodium | Kaempferol | Dextran sulfate sodium salt (MW 4500-5500) | Lamivudine | L-Lysine | Valproic Acid | Oxyresveratrol | L-Cystine | Decanedioic acid |
相关库 | 抗癌天然产物库 | 经典已知活性库 | 药物功能重定位化合物库 | 抗病毒库 | 高通量筛选天然产物库 | 抗感染天然产物库 | 抗癌活性化合物库 |