| Name | Theaflavin 3,3′-digallate |
| Description | Theaflavin 3,3'-digallate, a major polyphenol found in black tea, is an inducer of oxidative stress which has anti-inflammatory and cancer chemopreventive actions, it reduces tumor angiogenesis by downregulating HIF-1αand VEGF. |
| In vitro | Theaflavin 3,3'-digallate (TF-3) significantly reduces viral RNA levels and the expression of NS3 and U87 MG proteins in a dose-dependent manner when used at concentrations of 6.25, 12.5, and 25 μM for 24 hours [1]. Theaflavin 3,3'-digallate demonstrates potent antiviral activity against ZIKV replication in Vero E6 cells (EC50: 7.65 μM), while showing minimal cytotoxicity at doses up to 40 μM. Theaflavin 3,3'-digallate interferes with the post-entry phases of the ZIKV replication cycle, disrupting gene transcription and translation [1]. Theaflavin 3,3'-digallate leads to a rapid and sustained reduction in phospho-ERK1/2 and phospho-MEK1/2 protein levels and inhibits HCT116 cell growth (IC50: 17.26 μM) [2]. |
| In vivo | In vivo, Theaflavin 3,3'-digallatereduces serum levels of TNF-α, IL-1β, and IL-6 and decreases pulmonary edema, pulmonary congestion, and thickening of the alveolar wall in a mouse model of LPS-induced acute lung injury. It also inhibits osteoclast formation, polarization, and osteoclastic bone resorption in vitro and reduces titanium particle-induced bone erosion and the number of mature osteoclasts in mice in a dose-dependent manner [3]. |
| Storage | keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 10 mg/mL (11.51 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 1 mg/mL (1.15 mM), Sonication is recommended.
Ethanol : 10 mg/mL (11.51 mM), Sonication is recommended.
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| Keywords | ZP-10 | ZP10 | ZP 10 | ZIKV | VirusProtease | Virus Protease | U87 | translation | Theaflavin 3,3'-digallate | Theaflavin 3,3'digallate | Theaflavin 3,3' digallate | TF-3 | TF3 | TF 3 | replication | p53 | p21 | NS3 | NS2B-3 | NF-κB | MAPK | Inhibitor | inhibit | Human immunodeficiency virus | HSV | HIVProtease | HIV Protease | HIV | Herpes simplex virus | gp41 | ERK1/2 | Antioxidant | Akt | 0 |
| Inhibitors Related | Stavudine | Emtricitabine | Phenytoin sodium | Lamivudine | Penicillin G potassium | Valproic Acid | Oxyresveratrol | L-Cystine | (E)-3-(p-Tolyl)acrylaldehyde | Thymidine | Decanedioic acid | Dextran sulfate sodium salt (MW 5000) |
| Related Compound Libraries | Polyphenolic Natural Product Library | Flavonoid Natural Product Library | Bioactive Compound Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Inhibitor Library | Natural Product Library for HTS | Immunology/Inflammation Compound Library | Anti-infective Natural Product Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Anti-Cancer Active Compound Library |
United States
