yellow crystalline powder
5-Nitro-2-furoic acid is a representative of 2-substituted
5-nitrofurans. A number of nitrofurans have been used as
antibacterial, antiprotozoal, and anthelmintic drugs in
humans and animals. 2-Substituted 5-nitrofurans have been
used worldwide as human and veterinary medicines, food
preservatives, and feed additives, and they are utilized in
human medicine as antibacterial agents. Therefore, the relationship
between the antibacterial effect and the mutagenicity
of these compounds and their oxidized metabolites is
important. Comparison of the antibacterial effects and genotoxic
potencies of nitrofuran drugs and their oxidative
metabolites may provide a new direction for selecting nitrofuran
drugs for human use.
5-Nitro-2-furoic acid was used in the preparation of [1,2,4]triazolo[3,4-b][1,3,4]thiadiazines and [1,2,4]triazolo[3,4-b][1,3,4] thiadiazoles. The FT-IR and FT-Raman spectra of 5-Nitro-2-furoic acid has also been studied.
The FT-IR and FT-Raman spectra of 5-Nitro-2-furoic acid has been studied.
5-Nitro-2-furoic acid is a yellow crystalline powder with molecular
weight of 157.08 g mol-1 and density of 1.72 g cm-3. The
boiling point is 332.4 ℃ and the melting point is 185.00–
189.00 ℃ at 760 mm Hg. Vapor pressure is 5.83E-05 mm Hg
at 25 ℃ and enthalpy of vaporization is 60.71 kJ mol-1.
5-Nitro-2-furoic acid is very soluble in water. It is stable under
normal temperature and pressure.
The toxicological properties of this compound have not been
fully investigated. However, as a minimum precaution, it
should be considered harmful. Precautions should be taken
and procedures adopted to prevent exposure.
