漆树酸
漆树酸 性质
| 熔点 | 90-91℃ |
|---|---|
| 沸点 | 474.8±33.0 °C(Predicted) |
| 密度 | 1.002 |
| 储存条件 | -20°C |
| 溶解度 | 二甲基亚砜：≥20mg/mL |
| 形态 | 白色固体 |
| 酸度系数(pKa) | 3.08±0.30(Predicted) |
| 颜色 | 白色至米色 |
| 稳定性 | 自购买之日起，稳定期为 1 年。 其DMSO 或乙醇溶液可在 -20°C 下保存长达 3 个月。 |
| InChIKey | ADFWQBGTDJIESE-UHFFFAOYSA-N |
| LogP | 9.960 (est) |
漆树酸 用途与合成方法
| Target | Value |
|
Tip60
(Cell-free assay) | |
|
PCAF
(Cell-free assay) | 5 μM |
|
p300/CBP
(Cell-free assay) | 8.5 μM |
Anacardic Acid is a histone acetyltransferase, inhibits HAT activity of p300 and PCAF, with IC 50 s of ∼8.5 μM and ∼5 μM, respectively. Anacardic Acid (300 μM) inhibits mycelial growth. Anacardic Acid (50 μM) induces apoptosis-like characteristics in M. oryzae , and the effect is caspase independent. Anacardic Acid (1-80 μM) leads to loss of mitochondrial potential. Anacardic Acid (1-60 μM) also exhibits antioxidant activity in M. oryzae .
Anacardic acid (5 mg/kg, i.p.) attenuates the binding of HATs to the promoter of MEF2A and reverse hyperacetylation of H3K9ac caused by phenylephrine in C57BL/6 mice. Anacardic acid inhibits the level of transcription on MEF2A and cardiac development-related downstream genes, attenuates the protein overexpression of cardiac downstream genes caused by phenylephrine, reverses and attenuates cardiac hypertrophy in the hearts of mice exposed to phenylephrine, and attenuates the left ventricular pressure and improves cardiac function in the cardiac hypertrophy mice.
漆树酸 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-01-16 | S7582 | 漆树酸 | 16611-84-0 | 10mg | 804.57 |
| 2024-01-16 | S7582 | 16611-84-0 | 10mM (1mL in DMSO) | 810.81 |
