漆树酸

生物活性靶点体外研究体内研究漆树酸试剂级价格

漆树酸

CAS号:16611-84-0
英文名:6-pentadecylsalicylic acid
中文名:漆树酸
CBNumber:CB01364624
分子式:C22H36O3
分子量:348.52
MOL File:16611-84-0.mol

漆树酸化学性质

熔点 :90-91℃
沸点 :474.8±33.0 °C(Predicted)
密度 :1.002
储存条件 :-20°C
溶解度 :DMSO: ≥20mg/mL
形态 :White solid
酸度系数(pKa) :3.08±0.30(Predicted)
颜色 :white to beige
稳定性 :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
InChIKey :ADFWQBGTDJIESE-UHFFFAOYSA-N
LogP :9.960 (est)

安全信息

危险品标志 :Xi
危险类别码 :36
安全说明 :26
WGK Germany :3

漆树酸性质、用途与生产工艺

生物活性 Anacardic Acid (6-pentadecylsalicylic Acid)是一个有效的p300及p300/CBP相关因子 histone acetyltranferases的抑制剂，也具有抗细菌和抗微生物活性，抑制前列腺素合成，并抑制酪氨酸酶和脂肪氧合酶。
靶点
Target Value
Tip60
(Cell-free assay)
PCAF
(Cell-free assay) 5 μM
p300/CBP
(Cell-free assay) 8.5 μM
体外研究

Anacardic Acid is a histone acetyltransferase, inhibits HAT activity of p300 and PCAF, with IC ₅₀ s of ∼8.5 μM and ∼5 μM, respectively. Anacardic Acid (300 μM) inhibits mycelial growth. Anacardic Acid (50 μM) induces apoptosis-like characteristics in M. oryzae , and the effect is caspase independent. Anacardic Acid (1-80 μM) leads to loss of mitochondrial potential. Anacardic Acid (1-60 μM) also exhibits antioxidant activity in M. oryzae .
体内研究

Anacardic acid (5 mg/kg, i.p.) attenuates the binding of HATs to the promoter of MEF2A and reverse hyperacetylation of H3K9ac caused by phenylephrine in C57BL/6 mice. Anacardic acid inhibits the level of transcription on MEF2A and cardiac development-related downstream genes, attenuates the protein overexpression of cardiac downstream genes caused by phenylephrine, reverses and attenuates cardiac hypertrophy in the hearts of mice exposed to phenylephrine, and attenuates the left ventricular pressure and improves cardiac function in the cardiac hypertrophy mice.
化学性质粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于银杏。
用途抗菌。
用途用于含量测定/鉴定/药理实验等。