10-羟基喜树
10-羟基喜树 性质
| 熔点 | 230-237°C |
|---|---|
| 沸点 | 820.7±65.0 °C(Predicted) |
| 密度 | 1.60 |
| 储存条件 | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| 溶解度 | 二甲基亚砜：≥37.5 mg/ml（102.92mM） |
| 形态 | 淡黄色粉末 |
| 酸度系数(pKa) | 8.93±0.40(Predicted) |
| 颜色 | 粘黄色 |
| InChI | InChI=1S/C20H16N2O5/c1-2-20(26)14-7-16-17-11(5-10-6-12(23)3-4-15(10)21-17)8-22(16)18(24)13(14)9-27-19(20)25/h3-7,23,26H,2,8-9H2,1H3 |
| InChIKey | LCZZWLIDINBPRC-FQEVSTJZSA-N |
| SMILES | N1C2C(=CC(O)=CC=2)C=C2CN3C(C=12)=CC1C(CC)(O)C(=O)OCC=1C3=O |
| CAS 数据库 | 64439-81-2(CAS DataBase Reference) |
10-羟基喜树 用途与合成方法
| Target | Value |
|
DNA topoisomerase I
() |
(±)-10-Hydroxycamptothecin (10-OH-camptothecin) is an inhibitor of topo I. (±)-10-Hydroxycamptothecin (10-HCPT, 5-20 nM) markedly inhibits the proliferation of Colo 205 cells in a dose-dependent manner. (±)-10-Hydroxycamptothecin (5-20 nM) arrests Colo 205 cells in the G2 phase of the cell cycle and triggers apoptosis through a caspase-3-dependent pathway. (±)-10-Hydroxycamptothecin (HPT, 0.01-10 μg/mL) causes cell shrinage, nuclear fragmentation and condensed chromosomes and induces apoptosis of human urinary bladder cancer cell line (T24).
(±)-10-Hydroxycamptothecin (10-HCPT, 2.5-7.5 mg/kg/2 days, p.o.) significantly suppresss tumor growth in mouse xenografts. (±)-10-Hydroxycamptothecin (1-7.5 mg/kg, p.o., once per 2 or 4 days) causes no obvious acute toxicity in nude mice.
安全信息
| 危险品标志 | Xi,T |
|---|---|
| 危险类别码 | 36/37/38-25 |
| 安全说明 | 26-36-45 |
| 危险品运输编号 | UN 2811 6.1 / PGIII |
| WGK Germany | 3 |
| RTECS号 | UQ0491000 |
10-羟基喜树 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-11-08 | S3898 | 10-羟基喜树碱 | 64439-81-2 | 25mg | 794.43 |
| 2023-01-06 | XW196850971 | 10-羟基喜树碱 | 1g | 493 |
