CKD-602 盐酸盐
CKD-602 盐酸盐 性质
| 熔点 | >218°C (dec.) |
|---|---|
| 储存条件 | under inert gas (nitrogen or Argon) at 2-8°C |
| 溶解度 | DMSO（轻微）、甲醇（轻微、加热）、水（轻微） |
| 形态 | 固体 |
| 颜色 | 浅米色至浅棕色 |
| InChIKey | SJKBXKKZBKCHET-YEZAQYPZNA-N |
| SMILES | O=C1C2COC(=O)[C@](O)(CC)C=2C=C2C3=NC4=CC=CC=C4C(CCNC(C)C)=C3CN12.Cl |&1:7,r| |
CKD-602 盐酸盐 用途与合成方法
CKD-602 盐酸盐是一种新型喜树碱衍生物抗肿瘤药物。尽管ckd -602在临床中应用更广泛，但静脉输注引起的ckd -602相关毒性尚未得到评估。
Belotecan (CKD-602)是有效的DNA topoisomerase I抑制剂，可对多种类型的肿瘤发挥抗癌活性。| Target | Value |
|
DNA topoisomerase I
() |
Belotecan exerts a significant cytotoxic effect on YD-8, YD-9 and YD-38 cells in a time- and dose-dependent manner with IC 50 values of 2.4, 0.18 and 0.05 μg/mL at 72 h following treatment. Belotecan induces apoptosis in these cell lines. Belotecan induces G2/M phase arrest in oral squamous cell cancer cells. Belotecan shows a significant anticancer effect on glioma cells, with IC 50 values of 9.07 nM for LN229, 14.57 nM for U251 MG, 29.13 nM for U343 MG, and 84.66 nM for U87 MG.
Belotecan has a significant effect on intracerebral glioma growth, with animals having significantly smaller tumors than those in the control group.
CKD-602 盐酸盐 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026-09-15 | HY-13566A | CKD-602 盐酸盐 | 213819-48-8 | 1 mg | 548 |
| 2026-09-15 | HY-13566A | CKD-602 盐酸盐 | 213819-48-8 | 5mg | 1200 |
