White or almost white crystalline powder
Antistine HCl,Ciba,US,1948
Imidazoline binding site ligand and an antihistamine
Antihistaminic;H1 antagonist
Antazoline Hydrochloride acts as a histamine H1 receptor blocker, functioning as an antihistamine pharmaceutical.
15.4 parts of 2-chloromethylimidazoline hydrochloride, 45.8 parts of Nbenzylaniline
and 150 parts of alcohol are heated in an oil bath at 100° to
110°C. After distilling off the alcohol, the reaction mass is maintained at this
temperature for a further 3 hours and then triturated with water and 10 parts
of sodium bicarbonate. The unconsumed benzylaniline is extracted with ether
and the aqueous solution neutralized with dilute hydrochloric acid. By
evaporating this solution and extracting the residue with alcohol there is
obtained 2-(N-phenyl-N-benzylaminomethyl)imidazoline hydrochloride in the form of colorless crystals of melting point 227° to 229°C.
Imidazoline binding site ligand; a potent inducer of insulin secretion in rat pancreas. Also an antihistamine.
