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Meglumine Basic information
Meglumine Chemical Properties
  • Melting point:129-131.5 °C (lit.)
  • alpha -16.5 º (c=10, H2O, on dry sub)
  • Boiling point:331.88°C (rough estimate)
  • Density 1.2669 (rough estimate)
  • RTECS LZ4295770
  • refractive index -16.5 ° (C=2, H2O)
  • storage temp. 2-8°C
  • solubility H2O: 0.1 g/mL, clear, colorless
  • pkapKa 9.39(H2O,t =30.0,I=0.05N2)(Approximate)
  • form Crystalline Powder
  • color White to almost white
  • PH11 (10g/l, H2O, 20℃)
  • optical activity[α]20/D 16.5±0.5°, c = 2% in H2O
  • Water Solubility 100 g/100 mL (25 ºC)
  • Sensitive Air Sensitive & Hygroscopic
  • Merck 14,6078
  • BRN 385906
  • NIST Chemistry ReferenceN-methylglucamine(6284-40-8)
  • EPA Substance Registry SystemMeglumine (6284-40-8)
Safety Information
  • Risk Statements 36/37/38
  • Safety Statements 24/25
  • WGK Germany 3
  • 3-10-23
  • Autoignition Temperature~662 °F
  • TSCA Yes
  • HS Code 29221980
  • ToxicityLD50 orally in Rabbit: > 5000 mg/kg
Meglumine Usage And Synthesis
  • Chemical Propertieswhite to almost white crystalline powder
  • Chemical PropertiesMeglumine occurs as a white to slightly yellow-colored crystalline powder; it is odorless or with a slight odor.
  • Usesantiinflammatory
  • Usesexcipient in cosmetics and X-ray contrast media
  • UsesN-Methyl-D-glucamine is used in conjunction with iodinated organic compounds in contrast media viz. diatrizoate meglumine and iodipamide meglumine. It is useful in ion-exchange resins to chelate boron ions selectively. It is also used as an excipient in pharmaceuticals, in cosmetics and X-ray contrast media. It is also employed in the synthesis of surface active agents, pharmaceuticals and dyes.
  • Production MethodsMeglumine is prepared by the imination of glucose and monomethylamine, in an alcoholic solution, followed by catalytic hydrogenation.
  • DefinitionChEBI: A hexosamine that is D-glucitol in which the hydroxy group at position 1 is substituted by the nitrogen of a methylamino group. A crystalline base, it is used in preparing salts of certain acids for use as diagnostic radiopaque media, whi e its antimonate is used as an antiprotozoal in the treatment of leishmaniasis.
  • brand nameRenovue (Bracco).
  • General Description
    Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
    Meglumine is a glucose-derived secondary amine which is widely used as an excipient in pharmaceutical formulations.
  • Pharmaceutical ApplicationsMeglumine is an organic base used as a pH-adjusting agent and solubilizing agent, primarily in the preparation of soluble salts of iodinated organic acids used as X-ray contrast media.
  • SafetyMeglumine is widely used in parenteral pharmaceutical formulations and is generally regarded as a nontoxic material at the levels usually employed as an excipient.
    LD50 (mouse, IP): 1.68 g/kg
  • storageMeglumine does not polymerize or dehydrate unless heated above 150°C for prolonged periods.
    The bulk material should be stored in a well-closed container in a cool, dry place. Meglumine should not be stored in aluminum containers since it reacts to evolve hydrogen gas; it discolors if stored in containers made from copper or copper alloys. Stainless steel containers are recommended.
  • Purification MethodsCrystallise N-methyl-D(-)-glucamine from MeOH. Its solubility in H2O is 10%. [Karrer & Herkenrath Helv Chim Acta 20 83 1957 also for other N-alkyl derivatives, Beilstein 4 IV 1914.]
  • IncompatibilitiesIncompatible with aluminum, copper, mineral acids, and oxidizing materials. Differential scanning calorimetry studies suggest meglumine is incompatible with glipizide.
  • Regulatory StatusIncluded in the FDA Inactive Ingredients Database (injections; oral tablets). Included in parenteral medicines licensed in the UK.
Meglumine Preparation Products And Raw materials
Meglumine(6284-40-8)Related Product Information
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