Meglumine NEW

$0.00 25kg

$0.00 100kg

Min. Order1kg
Purity99%min
Cas No6284-40-8
Supply Ability500kgs
Update time2025-12-25

Wuhan Fortuna Chemical Co., Ltd

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Chemical Properties

Product Name	Meglumine
CAS No	6284-40-8
EC-No	228-506-9
Min. Order	1kg
Purity	99%min
Supply Ability	500kgs
Release date	2025/12/25

Meglumine Cas 6284-40-8

Specification

Items	Specifications	Results
Appearance	White crystalline powder	White crystalline power
Melting point	128℃～132℃	129.0℃～130.3℃
Loss on drying	≤0.5%	0.04%
Content	≥99.0%	99.90%
Specific optical rotation	﹣15.5º－﹣17.5º	﹣16.40º
Residue on ignition	≤0.1%	0.02%
Heavy metals	≤10ppm	Complies
Readily carbonizable substance	No deeper than the orange red no.2	Complies
Clarity of the solution	Clear and colourless Solution	Complies
Ultraviolet absorbancy degree	≤0.03	0.002
Nickel	≤5ppm	2ppm
Conclusion	The product complies with enterprise standard.

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Meglumine is a chemical compound derived from sugar (a sugar alcohol). Its primary role in medicine is not as an active drug itself, but as a helper ingredient or a carrier molecule. It is used to make certain drugs, especially those used in diagnostic imaging (contrast agents), soluble in water and safe to inject into the body.

Detailed Breakdown

1. Chemical Identity

Chemical Name: N-Methylglucamine
Source: It is derived from glucose, a simple sugar.
Structure: It is an amino sugar, meaning it has both an amine group (-NH₂) and multiple alcohol groups (-OH).

2. Primary Medical Use: As an Excipient

An excipient is an inactive substance that serves as the vehicle or medium for an active drug. Meglumine is a crucial excipient for two main reasons:

Solubility: Many acidic drugs are not soluble enough in water to be injected. Meglumine, being a base, can react with these acidic drugs to form a salt (e.g., Diatrizoate Meglumine, Iodoxamate Meglumine). This salt form is highly soluble in water.
Low Toxicity: Compared to other basic compounds like sodium, meglumine is generally well-tolerated and less toxic, which is vital for injectable medications.

3. Key Applications

A. Iodinated Contrast Agents (Radiology)
This is the most common and important use of meglumine. It is the counterion for many iodine-based contrast agents used in X-ray and CT scan procedures.

Purpose: To enhance the visibility of blood vessels, organs, and other internal structures.
Examples:

Diatrizoate Meglumine (e.g., in Gastrografin® for GI studies)
Iothalamate Meglumine
Ioxaglate Meglumine
Gadobenate Dimeglumine (this one is for MRI, see below)

B. MRI Contrast Agents
For Magnetic Resonance Imaging (MRI), meglumine is used with gadolinium-based agents.

Example: Gadobenate Dimeglumine (MultiHance®).

C. Pharmaceutical Salts for Active Drugs
Meglumine is also used to create stable and soluble salt forms of certain therapeutic drugs.

Example: Metformin Meglumine, which is a formulation of the common diabetes drug Metformin.
Example: Adenosine Monophosphate Meglumine, used for some viral infections like shingles.

4. Why is it Used Instead of Sodium?

For contrast agents, you will often see two forms: Meglumine Salt and Sodium Salt. The choice depends on the application:

Sodium Salts: Have higher osmolality (a measure of particle concentration), which can be more irritating to blood vessels and tissues.
Meglumine Salts: Have lower osmolality and are considered less irritating and less toxic to the heart and nervous system.

Because of this, meglumine-based agents are often preferred for:

Injections into arteries (e.g., cerebral angiography).
Patients with cardiac instability.
Procedures where lower irritation is critical.

Many modern contrast agents are actually a mixture of meglumine and sodium salts to balance good image quality with lower side effects.

Summary

Aspect	Description
What it is	A sugar-alcohol derivative (N-Methylglucamine).
Primary Role	An excipient (inactive carrier) to improve solubility and safety.
Main Use	Forming salts with iodinated contrast agents for X-rays and CT scans.
Key Advantage	Lower toxicity and lower osmolality compared to sodium salts, reducing side effects.
Other Uses	Also used in some MRI contrast agents and as a salt for certain therapeutic drugs.

In essence, meglumine is a vital but often overlooked component that makes many modern diagnostic imaging procedures and some treatments possible and safe.

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