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Meglumine

Meglumine Structure
Meglumine
  • CAS No.6284-40-8
  • Chemical Name:Meglumine
  • CBNumber:CB6411710
  • Molecular Formula:C7H17NO5
  • Formula Weight:195.21
  • MOL File:6284-40-8.mol
Meglumine Property
  • Melting point: :129-131.5 °C (lit.)
  • alpha  :-16.5 º (c=10, H2O, on dry sub)
  • Boiling point: :331.88°C (rough estimate)
  • Density  :1.2669 (rough estimate)
  • RTECS  :LZ4295770
  • refractive index  :-16.5 ° (C=2, H2O)
  • storage temp.  :2-8°C
  • solubility  :H2O: 0.1 g/mL, clear, colorless
  • pka :pKa 9.39(H2O,t =30.0,I=0.05N2)(Approximate)
  • form  :Crystalline Powder
  • color  :White to almost white
  • PH :11 (10g/l, H2O, 20℃)
  • optical activity :[α]20/D 16.5±0.5°, c = 2% in H2O
  • Water Solubility  :100 g/100 mL (25 ºC)
  • Sensitive  :Air Sensitive & Hygroscopic
  • Merck  :14,6078
  • BRN  :385906
  • InChIKey :MBBZMMPHUWSWHV-VZFHVOOUSA-N
  • EWG's Food Scores :1
  • FDA UNII :6HG8UB2MUY
  • NIST Chemistry Reference :N-methylglucamine(6284-40-8)
  • EPA Substance Registry System :Meglumine (6284-40-8)
Safety
  • Risk Statements  :36/37/38
  • Safety Statements  :24/25
  • WGK Germany  :3
  • F  :3-10-23
  • Autoignition Temperature :~662 °F
  • TSCA  :Yes
  • HS Code  :29221980
  • Toxicity :LD50 orally in Rabbit: > 5000 mg/kg
  • NFPA 704:
    0
    0 1
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements H315-H319-H335
  • Precautionary statements P261-P280a-P304+P340-P305+P351+P338-P405-P501a
Meglumine Price More Price(18)
  • Brand: Sigma-Aldrich
  • Product number: 66930
  • Product name : N-Methyl-D-glucamine
  • Purity: ReagentPlus , ≥99.0% (T)
  • Packaging: 100g
  • Price: $37.8
  • Updated: 2020/08/18
  • Buy: Buy
  • Brand: Sigma-Aldrich
  • Product number: Y0001209
  • Product name : Meglumine
  • Purity: European Pharmacopoeia (EP) Reference Standard
  • Packaging: 
  • Price: $190
  • Updated: 2021/03/22
  • Buy: Buy
  • Brand: Sigma-Aldrich
  • Product number: 8.18318
  • Product name : D(-)-N-Methylglucamine
  • Purity: for resolution of racemates for synthesis
  • Packaging: 250 g
  • Price: $53.37
  • Updated: 2021/03/22
  • Buy: Buy
  • Brand: Sigma-Aldrich
  • Product number: 1379140
  • Product name : Meglumine
  • Purity: United States Pharmacopeia (USP) Reference Standard
  • Packaging: 500mg
  • Price: $366
  • Updated: 2021/03/22
  • Buy: Buy
  • Brand: TCI Chemical
  • Product number: M0227
  • Product name : N-Methyl-D-glucamine
  • Purity: >99.0%(T)
  • Packaging: 25g
  • Price: $17
  • Updated: 2021/03/22
  • Buy: Buy

Meglumine Chemical Properties,Usage,Production

  • Chemical Properties white to almost white crystalline powder
  • Chemical Properties Meglumine occurs as a white to slightly yellow-colored crystalline powder; it is odorless or with a slight odor.
  • Uses antiinflammatory
  • Uses excipient in cosmetics and X-ray contrast media
  • Definition ChEBI: A hexosamine that is D-glucitol in which the hydroxy group at position 1 is substituted by the nitrogen of a methylamino group. A crystalline base, it is used in preparing salts of certain acids for use as diagnostic radiopaque media, whi e its antimonate is used as an antiprotozoal in the treatment of leishmaniasis.
  • Production Methods Meglumine is prepared by the imination of glucose and monomethylamine, in an alcoholic solution, followed by catalytic hydrogenation.
  • brand name Renovue (Bracco).
  • Pharmaceutical Applications Meglumine is an organic base used as a pH-adjusting agent and solubilizing agent, primarily in the preparation of soluble salts of iodinated organic acids used as X-ray contrast media.
  • Safety Meglumine is widely used in parenteral pharmaceutical formulations and is generally regarded as a nontoxic material at the levels usually employed as an excipient.
    LD50 (mouse, IP): 1.68 g/kg
  • storage Meglumine does not polymerize or dehydrate unless heated above 150°C for prolonged periods.
    The bulk material should be stored in a well-closed container in a cool, dry place. Meglumine should not be stored in aluminum containers since it reacts to evolve hydrogen gas; it discolors if stored in containers made from copper or copper alloys. Stainless steel containers are recommended.
  • Purification Methods Crystallise N-methyl-D(-)-glucamine from MeOH. Its solubility in H2O is 10%. [Karrer & Herkenrath Helv Chim Acta 20 83 1957 also for other N-alkyl derivatives, Beilstein 4 IV 1914.]
  • Incompatibilities Incompatible with aluminum, copper, mineral acids, and oxidizing materials. Differential scanning calorimetry studies suggest meglumine is incompatible with glipizide.
  • Regulatory Status Included in the FDA Inactive Ingredients Database (injections; oral tablets). Included in parenteral medicines licensed in the UK.
Meglumine Preparation Products And Raw materials
Raw materials
Preparation Products
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6284-40-8, MeglumineRelated Search:
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  • Fosaprepitant Impurity H
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  • D(-)-N-METHYLGLUCAMINE FOR RESOLUTION OF
  • (2R,3R,4R,5S)-6-(MethylaMino)hexane-1,2,3,4,5-pentaol
  • The most popular N-methylglucamine
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