설파티아졸소듐

한글명:설파티아졸소듐

카스 번호144-74-1

상품명:Sulfathiazole sodium

CBNumberCB6170572

분자식C9H10N3NaO2S2

포뮬러 무게279.31

MOL 파일144-74-1.mol

동의어(한글)

설파티아졸소듐

화학적 성질

저장 조건	Store at -20°C
용해도	H2O: 용해성50mg/mL
물리적 상태	가루
색상	흰색에서 황백색까지
BRN	3802297
안정성	흡습성
InChI	InChI=1S/C9H9N3O2S2.Na.H/c10-7-1-3-8(4-2-7)16(13,14)12-9-11-5-6-15-9;;/h1-6H,10H2,(H,11,12);;
InChIKey	PLYRQFRFHFKJLU-UHFFFAOYSA-N
SMILES	S(C1C=CC(N)=CC=1)(=O)(=O)NC1SC=CN=1.[NaH]
CAS 데이터베이스	144-74-1(CAS DataBase Reference)
EPA	Benzenesulfonamide, 4-amino-N-2-thiazolyl-, monosodium salt (144-74-1)

위험 및 안전 성명

위험품 표기	Xi
위험 카페고리 넘버	36/37/38
안전지침서	26-36-24/25-23
WGK 독일	2
RTECS 번호	WP2450000
F 고인화성물질	10

그림문자(GHS)

설파티아졸소듐 화학적 특성, 용도, 생산

개요
Sulfathiazole sodium salt is a short-acting sulfa drug. It was a common oral and topical antibiotic until less toxic alternatives were discovered. It is no longer used in humans. Sulfathiazole is added to the diet of laboratory animals to inhibit folate formation by gut bacteria. This ensures that the animal′s only source of available folate is from their diet. Sulfathiazole is a sulfonamide antibiotic that blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase. Sulfathiazole is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid. It is active against Gram positive bacteria, Gram negative bacteria and Chlamydia. Mode of resistance is via the alteration of dihydropteroate synthase or alternative pathway for folic acid synthesis.
용도
Sulfathiazole sodium salt is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA). It can also be used in biological study of thermotherapy and sulfonamide antibiotics deciphered Cyanobacteria and Proteobacteria microbiome in huanglongbing-affected Citrus paradise and Citrus limon.
일반 설명
Chemical structure: sulfonamide
Biochem/physiol Actions
Sulfathiazole is a sulfonamide antibiotic that blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase. Sulfathiazole is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid. It is active against Gram positive bacteria, Gram negative bacteria and Chlamydia. Mode of resistance is via the alteration of dihydropteroate synthase or alternative pathway for folic acid synthesis.

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