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용도
지베렐린 는 천연 식물 호르몬에 속합니다. 그것은 세포 분열과 신장을 자극하여 식물 줄기 신장을 자극 할 수 있습니다.
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독성
지베렐린 는 사람과 가축에게 안전합니다. 젊은 생쥐 (LD50)> 15000mg / kg에 대한 급성 경구 투여.
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순도시험
(1) 비선광도 : 이 품목 약 5g을 정밀히 달아 에탄올에 녹여 50mL(이 액을 조제시 가열해서는 아니 된다)로 하여 이 액의 선광도를 측정할 때, 
＝+75.0～+90.0°이어야 한다.
(2) 비소 : 이 품목을 비소시험법에 따라 시험할 때, 그 양은 4.0ppm 이하이어야 한다.
(3) 납 : 이 품목 5.0g을 취하여 원자흡광광도법 또는 유도결합플라즈마발광광도법에 따라 시험할 때, 그 양은 5.0ppm 이하이어야 한다.
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확인시험
이 품목 수 mg을 황산 2mL에 녹인 액은 녹색형광을 띤 적색의 용액을 나타낸다.
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정량법
이 품목 약 40mg을 정밀히 달아 메탄올을 가하여 50mL로 하고 이 액 10mL를 취하여 메탄올을 가하여 100mL로 한 것을 시험용액이라 한다. 따로, 지베렐린산표준품 약 25mg을 정밀히 달아 메탄올을 가하여 50mL로 하고 이 액 10mL를 취하여 메탄올을 가하여 50mL로 한 액을 표준용액으로 한다. 3개의 시험관에 시험용액 5mL, 표준용액 4mL와 5mL를 정확히 취하여 각각 가해주고 수욕상에서 증발건고 시킨 다음 90℃에서 10분간 건조한다. 이들을 상온으로 식혀주고 나서 황산(8→10) 10mL를 가하여 녹이고 수욕상에서 10분간 가열하고 10℃ 수욕상에서 5분간 식힌다. 희석한 황산을 대조액으로 하여 액층 1cm, 파장 535nm에서 각 용액의 흡광도를 측정하여 다음 계산식에 따라 함량을 구한다(단, 표준용액의 흡광도는 표준용액 4mL와 5mL를 사용하여 얻은 흡광도 중 시험용액의 흡광도에 근접한 값을 사용한다).
V : 표준용액의 채취량
Au : 시험용액의 흡광도
As : 표준용액의 흡광도
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정의
이 품목은 Gibberella fujikuroi의 배양물을 여과한 후 감압농축 한 것을 추출하여 결정을 석출시킨 다음 이를 정제하여 얻어지는 것이다.
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개요
Gibberellic acid (GA) is a tetracyclic di-terpenoid compound. It is one of the major hormones that can be synthesized in plants and fungi. It has various kinds of physiological effects including stimulating seed germination, inducing mitotic division of the leaves, triggering transitions from meristem to shoot growth, vegetative to flowering, determining sex expression and grain development through crosstalk with many environmental signals such as light, temperature and water. In lab and greenhouse, it can be used to trigger germination of seeds which has previously remained dormant. It can also used to induce the production of larger amount and bigger grapes, boosting the grape industry. In industry, GA can be produced from Solid-state Fermentation (SSF) which can have relatively high yield.
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화학적 성질
white powder
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용도
Gibberellic Acid is a a pentacyclic diterpene acid. Gibberellic Acid is a hormone that is found in plants which promotes the growth and elongation of cells. Gibberellic acid acts as a plant growth reg
ulator on account of its physiological and morphological effects in extremely low concentrations. Generally Gibberellic acid affects only the plant parts above the soil surface.
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정의
ChEBI: A C19-gibberellin that is a pentacyclic diterpenoid responsible for promoting growth and elongation of cells in plants.
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Biosynthesis
The presence of GA in actively growing tissues, i.e., shoot apices, young leaves, and flowers. Gibberellins (GAs; Gibberellic acids) being synthesized via the terpenoid pathway, require 3 enzymes viz., terpene synthase (TPSs), cytochrome P450 monooxygenase (P450s) and 2-oxoglutarate dependent dehydrogenase (2 ODDs), for the biosynthesis of bioactive GA from geranylgeranyl diphosphate in plants. Two terpene synthases, ent-copalyl diphosphate synthase (CPS) and ent-kaurene synthase (KS), located in plastids, are involved in the conversion of GGDP to tetracyclic hydrocarbon intermediate ent-kaurene. ent-Kaurene is then converted to GA12 by 2 P450s. First, ent-Kaurene oxidase (KO), present in the plastid's outer membrane, catalyzes the sequential oxidation of C-19 to produce ent-kaurenoic acid. Second, the kaurenoic acid oxidase (KAO) in the endoplasmic reticulum is converted to GA12. Bioactive GA4 is converted from GA12 through oxidations on C-20 and C-3 by GA 20-oxidase (GA20ox) and GA 3-oxidase (GA3ox)[3].
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일반 설명
White powder.
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공기와 물의 반응
Slightly water soluble .
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반응 프로필
Gibberellic acid is readily degraded by acids. .
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화재위험
Flash point data for Gibberellic acid are not available. Gibberellic acid is probably combustible.
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농업용
Plant growth hormone, Plant regulator: Gibberellic acids (Gibberellins) are naturally occurring plant hormones that are used as plant growth
regulators to stimulate both cell division and elongation
that affects leaves and stems. Applications of this hormone also hastens plant maturation and seed germination.
Delayed harvesting of fruits, allowing them to grow larger.
Gibberellic acids are applied to growing field crops, small
fruits, grapes, vines and tree fruit, and ornamentals, shrubs
and vines.
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상품명
ACTIVOL®; BERELEX®; BRELLIN®;
BOLL-SET®; CEKUGIB®; CROP BOOSTER®;
CYTOPLEX HMS®, DYNOGEN®; FALGRO®;
FLORALTONE® (with 2,3,5-triiodobenzoic acid);
FLORGIB®; FOLI-ZYME®; GIBBEX®; GIBBERELLIN
A 3 ®; GIBBERELLIN X®; GIBBREL®; GIBGRO®;
GIB-SOL®; GIB-TABS®; GIBRESCOL®; GROCEL®;
KALGIBB®; MAXON®; N-LARGE®; NOVAGIB®;
PGR-IV®; PRO-GIBB®; REGULEX®; RELEASE®;
RELAX®; RYZUP®; STIMULATE®; VIGOR®
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Safety Profile
Mildly toxic by
ingestion. Questionable carcinogen with
experimental tumorigenic data. hlutation
data reported. When heated to
decomposition it emits acrid smoke and
irritating fumes.
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Purification Methods
It crystallises from EtOAc, EtOAc/pet ether, MeOH/pet ether or Me2CO/pet ether. [Cross J Chem Soc 3022 1960, Beilstein 18 III/IV 6533.]
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참고 문헌
[1]https://en.wikipedia.org/wiki/Gibberellic_acid
[2]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4002599/
[3] Gupta, Ramwant, and S K Chakrabarty. “Gibberellic acid in plant: still a mystery unresolved.” Plant signaling & behavior vol. 8,9 (2013): e25504. doi:10.4161/psb.25504
[4]Celik, Ismail et al. “Evalution of toxicity of abcisic acid and gibberellic acid in rats: 50 days drinking water study.” Journal of enzyme inhibition and medicinal chemistry vol. 22,2 (2007): 219-26. doi:10.1080/14756360600988955
