살리실산 메틸

그림문자(GHS)

• 그림문자(GHS)

  

• 신호 어

  Danger

• 유해·위험 문구

  H302：삼키면 유해함

  H318：눈에 심한 손상을 일으킴

• 예방조치문구

  P264：취급 후에는 손을 철저히 씻으시오.

  P264：취급 후에는 손을 철저히 씻으시오.

  P270：이 제품을 사용할 때에는 먹거나, 마시거나 흡연하지 마시오.

  P280：보호장갑/보호의/보안경/안면보호구를 착용하시오.

  P301+P312：삼켜서 불편함을 느끼면 의료기관(의사)의 진찰을 받으시오.

  P305+P351+P338：눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.

  P501：...에 내용물 / 용기를 폐기 하시오.

살리실산 메틸 MSDS

• Birch-Me

살리실산 메틸 화학적 특성, 용도, 생산

• 물성

  살리실산메틸(Methyl salicylate)은 살리실산의 에스테르화 반응에 의해 생성된 살리실산메틸은 소염 - 진통제로 이용되고, 아세틸살리실산(아스피린)은 진통 - 해열제로 이용된다. 살리실산메틸과 아세틸살리실산은 모두 진통 작용을 하지만, 가수 분해가 일어날 경우 살리실산메틸은 인체에 해로운 메탄올이 생성되므로 먹는 약으로는 이용하지 않는다.

• 개요

  겨울 푸른 기름과 메틸 살리실산염으로도 알려진 Methyl salicylate는 캐나다와 윈난 (Yunnan)에서 생산 된 겨울 푸른 잎 줄기를 김을내어 얻을 수있다. 그것은이 부분에서 혈액 순환을 촉진시킬 수있는 국소 가래입니다. 근육통, 관절통 및 신경통. 또한 치약, 구강 세척제, 비누 에센스 및 음식 맛과 같은 유기 합성의 원료로 사용할 수 있습니다.

• 용도

  1. Methyl salicylate 연고는 진통제, 항 염증 및 살균 효과가있는 일반적인 피부병 치료제입니다. 국부적 인 자극을 일으킬 수 있고 구두로 복용하는 경우는 거의 없습니다. 피부에 흡수되기 쉽습니다. 그것의 팅크와 연고는 급성 류마티스 성 관절염, 요통과 근육통에 사용될 수 있습니다. 가려움증에도 사용할 수 있습니다. 또한 향료, 향료 및 방부제로 사용할 수 있습니다. 2.이 제품은 겨울철과 흡사 한 강한 냄새를 지니 며, 유칼립투스와 같은 일반적인 향미료의 혼합에서 약제 및 약제와 같은 약제 제제의 냄새 제거제로 자주 사용됩니다. 또한 응용 프로그램, 그리고 껌과 구강 세척제와 같은 다른 약물도 사용됩니다. 3. Methyl salicylate는 살충제, 살균제, 향수, 코팅제, 화장 용 잉크 및 섬유 염색제의 제조를위한 용매 및 중간체로도 사용됩니다. 4. 메틸 살리 실 레이트는 암모니아와 반응하여 해열 진통제 인 에틸 살리실 아민의 생산에 사용되는 살리 실 아미드를 형성합니다. 살리실 아미드 자체도 해열 진통제입니다. 메틸 살리 실 레이트의 아세틸 화에 의해 메틸 아세틸 살리 실 레이트 를 얻을 수있다. 6. 반응기에 메틸 살리 실 레이트와 무수 아세트산을 넣고 교반하면서 황산을 넣고 반응 온도는 60 ℃를 초과하지 않으며 약 1 시간이 경과하면 반응이 완료되고 반응물이 얼음물에 쏟아져 결정이 석출된다. 여과하고, 물로 세척하고, 건조시키고, 즉 명명 된 메틸 아세틸 살리 실 레이트. 7. 아세틸 살리실산은 4- 히드 록시 쿠마린의 고리 화에 의해 제조 될 수있다. 메틸 살리실산은 외부 사용을위한 약으로 사용됩니다

• 순도시험

    (1) 비중 : 이 품목의 비중은 1.180～1.185이어야 한다.

    (2) 굴절률 : 이 품목의 굴절률 은 1.535～1.538이어야 한다.

    (3) 용상 : 이 품목 1mL를 70% 에탄올 7mL에 녹일 때, 그 액은 징명하여야 한다.

    (4) 산가 : 이 품목의 산가는 향료시험법 중 산가측정법에 따라 시험할 때, 1 이하이어야 한다. 다만, 지시약은 페놀레드시액을 사용한다.

• 확인시험

    이 품목 1mL에 10% 알콜성수산화칼륨용액 25mL를 넣어 환류냉각기를 부착한 수욕 중에서 가열하면 특이한 향기는 없어진다. 다시 수욕 중에서 가열한 것을 식힌 다음 이에 물 75mL를 넣은 액은 확인시험법 중 살리실산염 (나)의 반응을 나타낸다.

• 정량법

    이 품목 약 0.9g을 정밀히 달아 향료시험법 중 에스테르가 및 에스테르함량측정법에 따라 시험한다. 다만, 지시약은 페놀레드시액을 사용한다.

  0.05N 알콜성수산화칼륨용액 1mL ＝ 76.08mg C₈H₈O₃

• 개요

  Methyl salicylate (oil of wintergreen or wintergreen oil) is an organic ester that is naturally produced by many species of plants. Some of the plants which produce it are called wintergreens, hence the common name. This compound is used as a fragrance. It is also found in liniments (rubbing ointments).

• 화학적 성질

  Methyl Salicylate is the main component of wintergreen oil and occurs in small quantities in other essential oils and fruits. It is a colorless liquid with a characteristic wintergreen-like odor. May be prepared by extraction from natural sources; or by esterification of salicylic acid with methanol.

• 출처

  Numerous plants produce methyl salicylate in very small amounts. Some plants, such as the following, produce more:
  Some species of the genus Gaultheria in the family Ericaceae, including Gaultheria procumbens, the wintergreen or eastern teaberry;
  Some species of the genus Betula in the family Betulaceae, particularly those in the subgenus Betulenta such as B. lenta, the black birch;
  All species of the genus Spiraea in the family Rosaceae, also called the meadowsweets.
  This compound is produced most likely as an anti-herbivore defense. If the plant is infected with herbivorous insects, the release of methyl salicylate may function as an aid in the recruitment of beneficial insects to kill the herbivorous insects.Aside from its toxicity, methyl salicylate may also be used by plants as a pheromone to warn other plants of pathogens such as tobacco mosaic virus.

• 용도

  Methyl salicylate is an organic ester that is commonly produced naturally by wintergreens. Methyl salicylate is utilize as a anti-herbivore defense system in various plants that produces it. Methyl sa licylate is also used in high concentrations as a rubefacient to treat joint, muscular pain and acute pain. Methyl slicylate is also used as a flavoring agent and often used to provide fragrance to pr oducts.

• 정의

  ChEBI: Methyl salicylate is a benzoate ester that is the methyl ester of salicylic acid. It has a role as a flavouring agent, a metabolite and an insect attractant. It is a benzoate ester, a member of salicylates and a methyl ester. It is functionally related to a salicylic acid.

• 생산 방법

  Methyl acetate, a novel acyl acceptor for biodiesel production has been developed, and a comparative study on Novozym 435-catalyzed transesterification of soybean oil for biodiesel production with different acyl acceptors has been studied (Noureddini et al., 2005).
  
  Figure 1 shows the effect of the molar ratio of methanol to sunflower oil on the methyl ester yield for catalytic (3% CaO) transesterification in supercritical methanol at 523 K.

• 제조 방법

  Methyl salicylate can be produced by esterifying salicylic acid with methanol. Commercial methyl salicylate is now synthesized, but in the past, it was commonly distilled from the twigs of Betula lenta (sweet birch) and Gaultheria procumbens (eastern teaberry or winter green).

• 일반 설명

  Colorless yellowish or reddish liquid with odor of wintergreen.

• 공기와 물의 반응

  Insoluble in water.

• 반응 프로필

  Methyl Salicylate is an ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides. Birch-Me is incompatible with oxidizers. Birch-Me is also incompatible with strong bases. Birch-Me may react with iron salts.

• 위험도

  Toxic by ingestion; use in foods restrictedby FDA, lethal dose 30 cc in adults, 10 cc in chil-dren.

• 건강위험

  Methyl salicylate is a highly toxic compound.The toxic symptoms in humans include nausea, vomiting, gastritis, diarrhea, respiratorystimulation, labored breathing, pulmonaryedema, convulsions, and coma. Ingestion of15 to 25 mL of this compound may befatal to humans. Application of the liquidon the skin and eyes produced severe irrita tion in rabbits. Oral, subcutaneous, or der mal administration of methyl salicylate intest animals produced specific developmen tal abnormalities affecting the eyes, ears, andcentral nervous system
  Toxicity of this compound is relativelymore severe in humans than in many com mon laboratory animals. The oral LD50 values in test animals were within the range800–1300 mg/kg.

• 화재위험

  Methyl salicylate is combustible.

• 색상 색인 번호

  This anti-inflammatory agent is found in a wide number of ointments and can induce allergic contact dermatitis.

• Safety Profile

  Human poison by ingestion. Moderately toxic to humans by an unspecified route. Moderately toxic experimentally by intraperitoneal, intravenous, and subcutaneous routes. An experimental teratogen. Human systemic effects by ingestion: flaccid paralysis without anesthesia, general anesthesia, dyspnea, nausea, vomiting, and respiratory stimulation. Experimental reproductive effects. A severe skin and eye irritant. Ingestion of relatively small amounts has caused severe poisoning and death. Combustible liquid when exposed to heat or flame; can react with oxibzing materials. To fight fire, use CO2, dry chemical. When heated to decomposition it emits acrid smoke and irritating fumes.

• Safety

  In pure form, methyl salicylate is toxic, especially when taken internally. A single teaspoon (5ml) of methyl salicylate contains 7g of salicylate, which is equivalent to more than twenty- three 300 mg aspirin tablets. The lowest published lethal dose is 101 mg / kg body weight in adult humans , (or 7.07 grams for a 70 - kg adult). It has proven fatal to small children in doses as small as 4 ml.[6] A seventeen-year- old cross - country runner at Notre Dame Academy on Staten Island, died in April 2007, after her body absorbed methyl salicylate through excessive use of topical muscle-pain relief products.
  Most instances of human toxicity due to methyl salicylate are a result of over-application of topical analgesics, especially involving children. Some people have intentionally ingested large amounts of oil of wintergreen. Salicylate, the major metabolite of methyl salicylate, may be quantitated in blood, plasma or serum to confirm a diagnosis of poisoning in hospitalized patients or to assist in an autopsy.

• Carcinogenicity

  Available data suggest that methyl salicylate is not carcinogenic.

• Purification Methods

  Dilute the ester with Et2O, wash with saturated NaHCO3 (it may effervesce due to the presence of free acid), brine, dry MgSO4, filter, evaporate and distil it. Its solubility is 1g/1.5L of H2O. The benzoyl derivative has m 92o (b 270-280o/120mm), and the 3,5-dinitrobenzoate has m 107.5o, and the 3,5-dinitrocarbamoyl derivative has m 180-181o. [Hallas J Chem Soc 5770 1965, Beilstein 10 IV 143.]

• Toxicity evaluation

  Oral LD50 values (mg/kg) for mouse, rat and rabbit are 1110, 887 and 1300, respectively. Oral LD50 values for child and adult human (mg/kg) are 228 and 506, respectively. Topical methyl salicylate generally rarely causes systemic toxicity, but it can be absorbed by the skin leading to stimulation of the central nervous system respiratory center, disturbance of lipid and carbohydrate metabolism, and disturbance of intracellular respiration. Severe poisoning can lead to acute lung injury, lethargy, coma, seizures, cerebral edema, and death. In the case of salicylate intoxication, treatment includes general supportive care, purification of the gastrointestinal tract with activated charcoal in the case of ingestion of salicylic acid, and monitoring of serum salicylic acid concentration. Bicarbonate infusion or hemodialysis can be used to enhance the elimination of salicylic acid.

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