Fexofenadine hydrochloride

한글명:Fexofenadine hydrochloride

카스 번호153439-40-8

상품명:Fexofenadine hydrochloride

CBNumberCB0256621

분자식C32H40ClNO4

포뮬러 무게538.13

MOL 파일153439-40-8.mol

화학적 성질

녹는점	148-150oC
RTECS 번호	CY1633377
저장 조건	2-8°C
용해도	디메틸설폭사이드(50mM) 및 메탄올에 용해됩니다.
물리적 상태	가루
색상	흰색에서 베이지색
Merck	14,4068
InChIKey	RRJFVPUCXDGFJB-UHFFFAOYSA-N
CAS 데이터베이스	153439-40-8(CAS DataBase Reference)

위험 및 안전 성명

위험품 표기	Xi
위험 카페고리 넘버	36/37/38
안전지침서	26-36
WGK 독일	3
HS 번호	2933399090

그림문자(GHS)

Fexofenadine hydrochloride 화학적 특성, 용도, 생산

개요
Fexofenadine is a histamine H₁ receptor antagonist (K_i = 10 nM). It reverses contraction of isolated rat tracheal strips induced by acetyl-β-methylcholine . Fexofenadine inhibits expression of IL-8 in TNF-α-stimulated HCT116 and COLO 205 cells. Oral administration of fexofenadine (2 and 10 mg/kg) reduces severity of colitis and phospho-IκB kinase activation in a mouse model of colitis induced by dextran sulfate sodium (DSS; ).
화학적 성질
Off-White Crystalline Solid
용도
Fexofenadine hydrochloride is used as an antihistamine that inhibits Cox-1, Cox-2, and is a histamine H1 receptor agonist.
일반 설명
Fexofenadine hydrochloride, (±)-4-[1-hydroxy-4-[4-(hydroxyldiphenylmethyl)- 1-piperinyl]butyl-α,α-dimethylbenzeneacetic acid (Allegra), occurs as a white to off-white crystalline powder that is freely soluble in methanol and ethanol, slightly soluble in chloroform and water, and insoluble in hexane.
This compound is marketed as a racemate and exists as a zwitterion in aqueous media at physiological pH. Fexofenadine is a primary oxidative metabolite of terfenadine. Terfenadine was developed during a search for new butyrophenone antipsychotic drugs as evidenced by the presence of the N-phenylbutanol substituent. It also contains a diphenylmethyl-piperidine moiety analogous to that found in the piperazine antihistamines.
생물학적 활성
Fexofenadine hydrochloride is a selective histamine H1 receptor antagonist (pKi = 8.1). Active metabolite of Terfenadine that displays non-sedating antiallergic effects. Fexofenadine hydrochloride counteracts histamine mediated immune suppression and improves immunotherapy response.

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