알파-[4-(1,1-디메틸에틸)페닐]-4-(하이드록시디페닐메틸)-1-피페리딘부타놀 ; 테르페나딘, 알다반

그림문자(GHS)

• 그림문자(GHS)

  

• 신호 어

  Danger

• 유해·위험 문구

  H413：장기적 영향에 의해 수생생물에 유해의 우려가 있음

• 예방조치문구

  P273：환경으로 배출하지 마시오.

  P501：...에 내용물 / 용기를 폐기 하시오.

알파-[4-(1,1-디메틸에틸)페닐]-4-(하이드록시디페닐메틸)-1-피페리딘부타놀 ; 테르페나딘, 알다반 MSDS

• Terfenadine

알파-[4-(1,1-디메틸에틸)페닐]-4-(하이드록시디페닐메틸)-1-피페리딘부타놀 ; 테르페나딘, 알다반 화학적 특성, 용도, 생산

• 화학적 성질

  White Solid

• 용도

  Terfenadine has been used to study the role of histamine in itch related to proteinase-activated receptors (PARs) in mice. Terfenadine has also been used to block histamine receptor type 1 to study the pathogenesis of 2,4-dinitrobenzene sulfonic acid (DNBS)-induced ulcerative colitis in rats.

• World Health Organization (WHO)

  The first clinically interesting histamine H-receptor1 antagonists were introduced in the late 1940s and early 1950s. Several H-antihistaminics have a similar cardiac effect to that seen with astemizole1 and terfenadine. Serious cardiovascular adverse reactions have been reported when used concomitantly with imidazole antifungals and macrolide antibiotics. See also under astemizole.

• 생물학적 활성

  Histamine H 1 receptor antagonist. Also blocks hERG and K ATP channels (IC 50 values are 204 nM and 1.2 μ M respectively). Inhibits the delayed rectifier K + current (I Kr ) in guinea pig ventricular myocytes (IC 50 = 50 nM). Activity prolongs QT and induces Torsades de pointes (TdP); cardiotoxic in vivo .

• Pharmacology

  Terfenadine not only differs from the other antihistamine drugs in its chemical structure, but also in that its action begins within 1–2 h and last approximately 12 h, reaching its peak of action in 3–4 h.

알파-[4-(1,1-디메틸에틸)페닐]-4-(하이드록시디페닐메틸)-1-피페리딘부타놀 ; 테르페나딘, 알다반 준비 용품 및 원자재

알파-[4-(1,1-디메틸에틸)페닐]-4-(하이드록시디페닐메틸)-1-피페리딘부타놀 ; 테르페나딘, 알다반 공급 업체

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알파-[4-(1,1-디메틸에틸)페닐]-4-(하이드록시디페닐메틸)-1-피페리딘부타놀 ; 테르페나딘, 알다반 관련 검색