부틸산화 히드록시톨루엔

그림문자(GHS)

• 그림문자(GHS)

  

• 신호 어

  Warning

• 유해·위험 문구

  H410：장기적 영향에 의해 수생생물에 매우 유독함

• 예방조치문구

  P273：환경으로 배출하지 마시오.

  P391：누출물을 모으시오.

  P501：...에 내용물 / 용기를 폐기 하시오.

부틸산화 히드록시톨루엔 MSDS

• 2,6-Di-tert-butyl-p-cresol

부틸산화 히드록시톨루엔 화학적 특성, 용도, 생산

• 물성

  물에는 녹지 않으나 메탄올·에탄올·석유에테르·벤젠·유지 등에는 잘 녹는다.

• 용도

  산화방지제.

• 순도시험

    (1) 융점 : 이 품목의 융점은 69～72℃이어야 한다.

    (2) 용상 : 이 품목 1g을 에탄올 10mL에 녹일 때, 그 액은 무색 징명하여야 한다.

    (3) 황산염 : 이 품목 0.5g에 물 30mL를 가하여 때때로 흔들어 섞으면서 수욕 중에서 5분간 가열하여 식힌 다음 여과하고, 묽은염산 1mL를 가하여 이를 시험용액으로 하여 황산염시험법에 따라 시험할 때, 그 양은 0.01N 황산 0.2mL에 대응하는 양 이하이어야 한다.

    (4) 비소 : 이 품목을 비소시험법에 따라 시험할 때, 그 양은 4.0ppm 이하이어야 한다.

    (5) 납 : 이 품목 5.0g을 취하여 원자흡광광도법 또는 유도결합플라즈마발광광도법에 따라 시험할 때, 그 양은 2.0ppm 이하이어야 한다.

    (6) 수은 : 이 품목을 수은시험법에 따라 시험할 때, 그 양은 1.0ppm 이하이어야 한다.

    (7) 파라크레졸 : 이 품목 1g을 취하여 물 10mL 및 암모니아수 1mL를 가하고 때때로 흔들어 혼합하며 수욕 중에서 3분간 가열하고 식힌 후 여과하고 여과지상의 잔류물을 소량의 물로 씻고 세액은 여액과 합쳐 물을 가해 100mL로 한 것을 시험용액으로 한다. 시험용액 3mL를 취해 네슬러관에 넣고 인몰리브덴산‧에탄올(1→20) 1mL 및 암모니아시액 0.2mL를 가해 섞고 다시 물을 가해 50mL로 하여 10분간 방치할 때, 이 액은 파라크레졸용액 (1→100,000) 3mL를 취해 시험용액과 동일하게 조작하여 얻은 액의 색보다 진하여서는 아니 된다(파라크레졸로서 0.1% 이하).

• 확인시험

    (1) 이 품목 5mg에 5-니트로소-8-옥시퀴노린황산용액(1→100) 1～2방울을 가하면 녹으면서 황색을 나타내고 이어 액은 적갈색이 된다.

    (2) 이 품목의 에탄올용액(1→30) 1mL에 묽은염화제이철시액 3～4방울을 가할 때, 색을 나타내지 아니하나 다시 α,α''-디피리딜의 작은 결정을 가하면 적색을 나타낸다. 다만, 염화제이철시액은 공시험에서 색이 나타나지 않은 것을 사용한다.

• 강열잔류물

    이 품목의 강열잔류물은 0.02% 이하이어야 한다.

• 개요

  The antioxidant butylated hydroxytoluene is contained in food, adhesive glues, industrial oils and greases, including cutting fluids. Sensitization seems very rare.

• 화학적 성질

  Butylated hydroxytoluene occurs as a white or pale yellow crystalline solid or powder with a faint characteristic phenolic odor.

• 출처

  Not reported found naturally.

• 용도

  Butylated Hydroxytoluene (BHT) is an antioxidant that functions similarly to butylated hydroxyanisole (BHA) but is less stable at high temperatures. It is also termed 2,6-di-tert-butyl-para-cresol. See Butylated Hydroxyanisole.

• 정의

  ChEBI: A member of the class of phenols that is 4-methylphenol substituted by tert-butyl groups at positions 2 and 6.

• 생산 방법

  Prepared by the reaction of p-cresol with isobutene.

• 제조 방법

  Butylated Hydroxytoluene is produced commercially by the alkylation of para-cresol with isobutylene. Butylated Hydroxytoluene is also produced by several western European manufacturers, production/processing plants in Germany, France, the Netherlands, United Kingdom and Spain.

• 일반 설명

  White crystalline solid.

• 공기와 물의 반응

  Insoluble in water.

• 반응 프로필

  Phenols, such as 2,6-Di-tert-butyl-4-methylphenol, do not behave as organic alcohols, as one might guess from the presence of a hydroxyl (-OH) group in their structure. Instead, they react as weak organic acids. Phenols and cresols are much weaker as acids than common carboxylic acids (phenol has Ka = 1.3 x 10^[-10]). These materials are incompatible with strong reducing substances such as hydrides, nitrides, alkali metals, and sulfides. Flammable gas (H2) is often generated, and the heat of the reaction may ignite the gas. Heat is also generated by the acid-base reaction between phenols and bases. Such heating may initiate polymerization of the organic compound. Phenols are sulfonated very readily (for example, by concentrated sulfuric acid at room temperature). The reactions generate heat. Phenols are also nitrated very rapidly, even by dilute nitric acid. Nitrated phenols often explode when heated. Many of them form metal salts that tend toward detonation by rather mild shock. May react with oxidizing materials.

• 건강위험

  2,6-Di-tert-butyl-p-cresol or Butylated Hydroxytoluene is of relatively low acute toxicity in animals, and there is no evidence of either acute or chronic effects among exposed workers.

• 화재위험

  2,6-Di-tert-butyl-4-methylphenol is combustible.

• Pharmaceutical Applications

  Butylated hydroxytoluene is used as an antioxidant in cosmetics, foods, and pharmaceuticals. It is mainly used to delay or prevent the oxidative rancidity of fats and oils and to prevent loss of activity of oil-soluble vitamins.
  Butylated hydroxytoluene is also used at 0.5–1.0% w/w concentration in natural or synthetic rubber to provide enhanced color stability.
  Butylated hydroxytoluene has some antiviral activity and has been used therapeutically to treat herpes simplex labialis.

• 색상 색인 번호

  This antioxidant is contained in food, adhesive glues, industrial oils, and greases, including cutting fluids. Sensitization seems very rare.

• Carcinogenicity

  The IARC has determined that there is limited evidence for the carcinogenicity of Butylated Hydroxytoluene in experimental animals.Butylated Hydroxytoluene has given primarily negative results in a large number of in vivo and in vitro genotoxic assays.No significant reproductive effects were observed in three-generation toxicity studies in mice administered up to 0.4% in the diet.6 The 2003 ACGIH threshold limit valuetime- weighted average (TLV-TWA) for 2,6-ditert- butyl-p-cresol is 2mg/m3.

• 환경귀착

  The metabolites of Butylated Hydroxytoluene can bind to cellular macromolecules, such as proteins and DNA, and cause toxicity.

• 잠재적 노출

  DBPC is used as a food and feed additive, flavor, and packaging material; as an antioxidant in human foods and animal feeds. It is also used as an antioxidant to sta- bilize petroleum fuels, rubber and vinyl plastics.

• Safety Profile

  Poison by intraperitoneal andintravenous routes. Moderately toxic by ingestion. Anexperimental teratogen. Other experimental reproductiveeffects. A human skin irritant. A skin and eye irritant.Questionable carcinogen with experimental carcinogenicand.

• Safety

  Butylated hydroxytoluene is readily absorbed from the gastrointestinal tract and is metabolized and excreted in the urine mainly as glucuronide conjugates of oxidation products. Although there have been some isolated reports of adverse skin reactions, butylated hydroxytoluene is generally regarded as nonirritant and nonsensitizing at the levels employed as an antioxidant.
  The WHO has set a temporary estimated acceptable daily intake for butylated hydroxytoluene at up to 125 μg/kg body-weight.
  Ingestion of 4 g of butylated hydroxytoluene, although causing severe nausea and vomiting, has been reported to be nonfatal.
  LD₅₀ (guinea pig, oral): 10.7 g/kg
  LD₅₀ (mouse, IP): 0.14 g/kg
  LD₅₀ (mouse, IV): 0.18 g/kg
  LD₅₀ (mouse, oral): 0.65 g/kg
  LD₅₀ (rat, oral): 0.89 g/kg

• 저장

  Exposure to light, moisture, and heat causes discoloration and a loss of activity. Butylated hydroxytoluene should be stored in a wellclosed container, protected from light, in a cool, dry place.

• 운송 방법

  UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.

• Purification Methods

  Dissolve Butylated Hydroxytoluene in n-hexane at room temperature, then cool with rapid stirring, to -60o. The precipitate is separated, redissolved in hexane, and the process is repeated until the mother liquor is no longer coloured. The final product is stored under N2 at 0o [Blanchard J Am Chem Soc 82 2014 1960]. It has also been recrystallised from EtOH, MeOH, *benzene, n-hexane, methylcyclohexane or pet ether (b 60-80o), and is dried in a vacuum. [Beilstein 6 IV 3511.]

• 비 호환성

  Butylated hydroxytoluene is phenolic and undergoes reactions characteristic of phenols. It is incompatible with strong oxidizing agents such as peroxides and permanganates. Contact with oxidizing agents may cause spontaneous combustion. Iron salts cause discoloration with loss of activity. Heating with catalytic amounts of acids causes rapid decomposition with the release of the flammable gas isobutene.

• Regulatory Status

  GRAS listed. Accepted as a food additive in Europe. Included in the FDA Inactive Ingredients Database (IM and IV injections, nasal sprays, oral capsules and tablets, rectal, topical, and vaginal preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

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