부틸레이티드 하이드록시 아니솔

그림문자(GHS)

• 그림문자(GHS)

  

• 신호 어

  Warning

• 유해·위험 문구

  H302：삼키면 유해함

  H411：장기적 영향에 의해 수생생물에 유독함

• 예방조치문구

  P264：취급 후에는 손을 철저히 씻으시오.

  P264：취급 후에는 손을 철저히 씻으시오.

  P270：이 제품을 사용할 때에는 먹거나, 마시거나 흡연하지 마시오.

  P273：환경으로 배출하지 마시오.

  P301+P312：삼켜서 불편함을 느끼면 의료기관(의사)의 진찰을 받으시오.

  P391：누출물을 모으시오.

  P501：...에 내용물 / 용기를 폐기 하시오.

부틸레이티드 하이드록시 아니솔 MSDS

• 3(2)-tert-Butyl-4-hydroxyanisole

부틸레이티드 하이드록시 아니솔 화학적 특성, 용도, 생산

• 순도시험

    (1) 융점 : 이 품목의 융점은 57～65℃이어야 한다.

    (2) 용상 : 이 품목 0.5g을 에탄올 10mL에 녹일 때 이 액은 무색 징명하여야 한다.

    (3) 황산염 : 이 품목 0.5g을 아세톤 35mL에 녹이고 묽은염산 1mL 및 물을 가하여 50mL로 하여 시험용액으로 한다. 따로 0.01N 황산 0.2mL에 아세톤 35mL, 묽은염산 1mL 및 물을 가하여 50mL로 하여 대조액으로 한다. 양 액에 염화바륨시액 2mL씩 가하여 잘 섞고 10분간 방치할 때, 시험용액의 탁도는 대조액의 탁도 이하이어야 한다.

    (4) 비소 : 이 품목을 비소시험법에 따라 시험할 때, 그 양은 4.0ppm 이하이어야 한다.

    (5) 납 : 이 품목 5.0g을 취하여 원자흡광광도법 또는 유도결합플라즈마발광광도법에 따라 시험할 때, 그 양은 2.0ppm 이하이어야 한다.

    (6) 수은 : 이 품목을 수은시험법에 따라 시험할 때, 그 양은 1.0ppm 이하이어야 한다.

    (7) 파라히드록시아니솔 : 이 품목 1g에 에테르․석유벤진의 혼액(1 : 1) 20mL를 가하여 녹인다. 이에 물 10mL 및 수산화나트륨시액 1mL를 가하고 잘 흔들어 섞은 다음 정치하여 하층을 취한다. 이 액에 에테르․석유벤진의 혼액(1 : 1) 20mL를 가하여 잘 흔들어 섞은 후 정치하여 하층을 취해서 물을 가하여 500mL로 한다. 이 액 1mL를 네슬러관에 취해 수산화나트륨시액 2mL, 붕산용액(3→100) 5mL 및 물을 가하여 30mL로 한다. 이에 4-아미노안티피린용액(1→1,000) 5mL를 가하여 흔들어 섞은 다음 페리시안화칼륨용액(1→100) 1mL를 가해 흔들어 섞고 다시 물을 가하여 50mL로 하여 15분간 방치 할 때, 그 액의 색은 염화제일코발트비색표준원액 0.6mL에 물을 가해 50mL로 한 액의 색보다 진하여서는 아니 된다.

• 확인시험

    (1) 이 품목의 에탄올용액(1→100) 2～3mL에 붕사용액(1→50) 2～3방울 및 2, 6-디클로로퀴논클로로이미드의 작은 결정을 가하여 흔들어 섞으면 액은 청남색을 나타낸다.

    (2) 「디부틸히드록시톨루엔」의 확인시험 (2)에 따라 시험한다.

• 강열잔류물

    이 품목의 강열잔류물은 0.05% 이하이어야 한다.

• 개요

  Butylated hydroxyanisole (BHA) is an antioxidant widely used in food. Because it is contained in pastry, it can induce sensitization in caterers.

• 화학적 성질

  Butylated hydroxyanisole occurs as a white or almost white crystalline powder or a yellowish-white waxy solid with a faint, characteristic aromatic odor.

• 출처

  BHA is not known to occur as a natural product.

• 용도

  Butylated Hydroxyanisole is an antioxidant consisting of a mixture of two isomers of tert-butyl-4-hydroxyanisole. Butylated Hydroxyanisole is used in food preservation as it antioxidant properties pre vent food from becoming rancid. Butylated Hydroxyanisoleas is also used in animal feed, petroleum products, and cosmetics.

• 정의

  A mixture of 2- and 3-tert-4-methoxyphenol.

• 생산 방법

  Prepared by the reaction of p-methoxyphenol with isobutene.

• 일반 설명

  White, beige or slightly yellow waxy solid with an aromatic odor and a slightly bitter burning taste.

• 공기와 물의 반응

  Insoluble in water.

• 반응 프로필

  Butylated hydroxyanisole degrades with prolonged exposure to sunlight. Exhibits antioxidant properties and synergism with acids, BHT, propyl gallate, hydroquinone, methionine, lecithin and thiodipropionic acid. Butylated hydroxyanisole exhibits antioxidant properties as a scavenger of free radicals. Butylated hydroxyanisole is incompatible with oxidizing agents and ferric salts.

• 위험도

  Toxic by ingestion. Use in foods restricted; consult FDA regulations.

• 화재위험

  Butylated hydroxyanisole is combustible.

• Pharmaceutical Applications

  Butylated hydroxyanisole is an antioxidant with some antimicrobial properties. It is used in a wide range of cosmetics, foods, and pharmaceuticals. When used in foods, it is used to delay or prevent oxidative rancidity of fats and oils and to prevent loss of activity of oil-soluble vitamins.
  Butylated hydroxyanisole is frequently used in combination with other antioxidants, particularly butylated hydroxytoluene and alkyl gallates, and with sequestrants or synergists such as citric acid.
  FDA regulations direct that the total content of antioxidant in vegetable oils and direct food additives shall not exceed 0.02% w/w (200 ppm) of fat or oil content or essential (volatile) oil content of food.
  USDA regulations require that the total content of antioxidant shall not exceed 0.01% w/w (100 ppm) of any one antioxidant or 0.02% w/w combined total of any antioxidant combination in animal fats.
  Japanese regulations allow up to 1 g/kg in animal fats.

• 색상 색인 번호

  BHA is an antioxidant widely used in cosmetics and food. Contained in pastry, it can induce sensitization in caterers.

• Safety Profile

  Confirmed carcinogen with experimental carcinogenic, neoplastigenic, and tumorigenic data. Moderately toxic by ingestion and intraperitoneal routes. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits acrid and irritating fumes

• Safety

  Butylated hydroxyanisole is absorbed from the gastrointestinal tract and is metabolized and excreted in the urine with less than 1% unchanged within 24 hours of ingestion. Although there have been some isolated reports of adverse skin reactions to butylated hydroxyanisole, it is generally regarded as nonirritant and nonsensitizing at the levels employed as an antioxidant.
  Concern over the use of butylated hydroxyanisole has occurred following long-term animal feeding studies. Although previous studies in rats and mice fed butylated hydroxyanisole at several hundred times the US-permitted level in the human diet showed no adverse effects, a study in which rats, hamsters, and mice were fed butylated hydroxyanisole at 1–2% of the diet produced benign and malignant tumors of the forestomach, but in no other sites. However, humans do not have any region of the stomach comparable to the rodent forestomach and studies in animals that also do not have a comparable organ (dogs, monkeys, and guinea pigs) showed no adverse effects. Thus, the weight of evidence does not support any relevance to the human diet where butylated hydroxyanisole is ingested at much lower levels. The WHO acceptable daily intake of butylated hydroxyanisole has been set at 500 μg/kg body-weight.
  LD₅₀ (mouse, oral): 1.1–2.0 g/kg
  LD₅₀ (rabbit, oral): 2.1 g/kg
  LD₅₀ (rat, IP): 0.88 g/kg
  LD₅₀ (rat, oral): 2.0 g/kg

• Carcinogenicity

  Butylated hydroxyanisole (BHA) is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.

• 환경귀착

  The metabolites of BHA can bind to cellular macromolecules, such as proteins and DNA, and cause toxicity.

• 저장

  Exposure to light causes discoloration and loss of activity. Butylated hydroxyanisole should be stored in a well-closed container, protected from light, in a cool, dry place.

• 운송 방법

  UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1—Poisonous materials, Technical Name Required. UN3077 Environmentally hazardous substances, solid, n.o.s., Hazard class: 9; Labels: 9— Miscellaneous hazardous material, Technical Name Required

• 비 호환성

  Butylated hydroxyanisole is phenolic and undergoes reactions characteristic of phenols. It is incompatible with oxidizing agents and ferric salts. Trace quantities of metals and exposure to light cause discoloration and loss of activity.

• 폐기물 처리

  Suggested: Dispose of contents and container to an approved waste disposal plant. All federal, state, and local environmental regulations must be observed.

• Regulatory Status

  GRAS listed. Accepted as a food additive in Europe. Included in the FDA Inactive Ingredients Database (IM and IV injections, nasal sprays, oral capsules and tablets, and sublingual, rectal, topical, and vaginal preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Nonmedicinal Ingredients.

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