チモール

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Danger

• 危険有害性情報

  H302：飲み込むと有害

  H314：重篤な皮膚の薬傷?眼の損傷

  H411：長期的影響により水生生物に毒性

• 注意書き

  P260：粉じん/煙/ガス/ミスト/蒸気/スプレーを吸入しないこ と。

  P273：環境への放出を避けること。

  P280：保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。

  P301+P312：飲み込んだ場合：気分が悪い時は医師に連絡する こと。

  P303+P361+P353：皮膚（または髪）に付着した場合：直ちに汚染された衣 類をすべて脱ぐこと/取り除くこと。皮膚を流水/シャワー で洗うこと。

  P305+P351+P338：眼に入った場合：水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。

チモール 価格

MSDS Information

• 5-Methyl-2-(1-methylethyl)phenol

チモール 化学特性,用途語,生産方法

• 外観

  白色, 結晶～結晶性粉末

• 定義

  本品は、フェノール(*)の誘導体であり、次の化学式で表される。
  参照表示名称：フェノール

• 性質

  5-methyl-2-(1-methylethyl)phenol．C10H14O(150.2)．チモールは，精油成分の一つ．チミアン油やアヨワン油などに含まれる．無色透明の結晶で，特有の芳香がある．融点50～51.5 ℃，沸点233 ℃．d₁₅ 0.976．n²⁰_D 1.5226．エタノール，エーテル，クロロホルム，ベンゼンなどに可溶，水に微溶．練り歯磨き，化粧品などに用いられる．芳香性のにおいと舌を焼くような刺激性のある無色の結晶または結晶性粉末で、殺菌、防腐、駆虫剤として知られる。森北出版「化学辞典（第2版）

• 溶解性

  水に殆ど不溶。エタノール, アセトンに易溶。エタノール及びアセトンに溶けやすく、水にほとんど溶けない。

• 用途

  駆虫薬 抗細菌薬 殺菌薬 歯科用薬、香料、フレバーの原料成分、ラベンダーの香気成分

• 用途

  防腐剤、殺菌剤、調製液原料、分析用(発色試薬)、有機合成原料。

• 用途

  チモールは，防腐剤，殺菌剤として歯磨剤，セッケンなどに添加。駆虫剤，メントール合成原料に使用。タチジャコウソウ油の主成分。m‐クレゾールから合成。回虫や蟯虫(ぎょうちゅう)の駆除に内服により用いられたことがあったが、現在ではほとんどこの目的では使用されない。歯科用にむし歯の穴（う窩(か)）および根管の消毒、歯髄炎の鎮痛・鎮静に20％液が用いられる。そのほか、外用液剤、軟膏(なんこう)剤、外用散剤に配合されて局所の殺菌用に用いられ、また含嗽(がんそう)剤、洗浄剤、歯みがきに添加して使用される。［幸保文治］

• 化粧品の成分用途

  変性剤、口腔衛生剤、香料

• 効能

  駆虫薬, 保存剤

• 商品名

  チモール (マイラン製薬)

• 化学的特性

  Thymol occurs as colorless or often large translucent crystals, or as a white crystalline powder with a herbal odor (aromatic and thymelike) and a pungent caustic taste.

• 天然物の起源

  Reported in the essential oils of Monarda punctata, Satureia thymera, Origanum floribundum, Ocimum viride, Ocimum gratissimum and particularly in thyme (Thymus vulgaris L., T. capitatus, T. serpillum L.), where it is contained up to 50%. Also reported found in citrus peel oils, orange and tangerine juice, bilberry, cranberry, blueberry, papaya, blackberry, celery seed, chive, clove bud, cumin seed, ginger, peppermint oil, corn mint oil, Scotch spearmint oil, nutmeg, parsley, thyme, Gruyere cheese, parmesan cheese, romano cheese, white wine, black tea, plum, sweet and wild marjoram, fenugreek, mango, cardamom, dill herb and seed, licorice, lovage leaf, buckwheat, sweet corn, elder flower, cherimoya, rosemary, lemon balm, Spanish sage, anise hyssop, sweet grass oil, eucalyptus oil and mastic gum oil.

• 使用

  Thymol is an antimicrobial compound which can increase the efficacy of antibiotics involving drug resistant bacteria. It inhibits growth and lactate production as well as reduces cellular glucose upta ke within the bacteria.

• 定義

  thymol: A pungent-smelling colourless crystalline compound, C₁₀H₁₄O;m.p. 51°C. It occurs in various essentialoils, particularly oil of thyme,and can be made by using iron(III)chloride to oxidize piperitone (itselfextracted from eucalyptus oil). Itsantiseptic properties are exploited ingargles and mouthwashes.

• 調製方法

  Thymol is obtained from the volatile oil of thyme (Thymus vulgaris Linne′ (Fam. Labiatae)) by fractional distillation followed by extraction and recrystallization. Thyme oil yields about 20–30% thymol. Thymol may also be produced synthetically from pcymene, menthone, or piperitone, or by the interaction of m-cresol with isopropyl chloride.

• 一般的な説明

  Thymol is a monoterpene phenol derivative. It is a key volatile aroma constituent of the essential oil of plants such as thyme, basil, and oregano. It has strong antioxidant, antibacterial, anticarcinogenesis, anti-inflammatory, and antiseptic properties.

• 臨床応用

  Isopropyl m-cresol is extracted from oil of Thymus vulgaris(thyme, of the mint family) by partitioning into alkalineaqueous medium followed by acidification. The crystals obtainedfrom the mother liquor are large and colorless, with athymelike odor. Thymol is only slightly soluble in water,but it is extremely soluble in alcohols and other organic solvents.Thymol has mild fungicidal properties and is used inalcohol solutions and in dusting powders for the treatmentof tinea (ringworm) infections.

• 安全性プロファイル

  Poison by ingestion and intravenous routes. Moderately toxic by subcutaneous route. Experimental reproductive effects. Mutation data reported. An allergen. Incompatible with acetanilide. When heated to decomposition it emits acrid smoke and irritating fumes. An FDA over-the-counter drug used as an antibacterial and antifungal agent.

• 安全性

  Thymol is used in cosmetics, foods, and pharmaceutical applications as an excipient. However, thymol may be irritating when inhaled or following contact with the skin or eyes. It may also cause abdominal pain and vomiting, and sometimes stimulation followed by depression of the central nervous system following oral consumption; fats and alcohol increase absorption and aggravate symptoms.
  Respiratory arrest, attributed to acute nasal congestion and edema, has been reported in a 3-week-old patient due to the erroneous intranasal application of Karvol, a combination product that includes thymol. The patient recovered, but it was recommended that inhalation decongestants should not be used in children under the age of 5 years.
  LD50 (guinea pig, oral): 0.88 g/kg
  LD50 (mouse, IP): 0.11 g/kg
  LD50 (mouse, IV): 0.1 g/kg
  LD50 (mouse, oral): 0.64 g/kg
  LD50 (mouse, SC): 0.243 g/kg
  LD50 (rat, oral): 0.98 g/kg

• 貯蔵

  Thymol should be stored in well-closed, light-resistant containers, in a cool, dry, place. Thymol is affected by light.

• 不和合性

  Thymol is incompatible with iodine, alkalis, and oxidizing agents. It liquefies, or forms soft masses, on trituration with acetanilide, antipyrine, camphor, monobromated camphor, chloral hydrate, menthol, phenol, or quinine sulfate. The antimicrobial activity of thymol is reduced in the presence of proteins.

• 規制状況(Regulatory Status)

  GRAS listed. Included in the FDA Inactive Ingredients Database (inhalation, liquid; oral, powder for solution). Included in nonparenteral medicines (topical creams and ointments) licensed in the UK. Included in the Canadian List of Acceptable Nonmedicinal Ingredients.

チモール 上流と下流の製品情報

チモール 生産企業

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チモール スペクトルデータ(¹HNMR、¹³CNMR、IR1、IR2、IR3、MS、Raman)

89-83-8, チモール キーワード