クロロアセチルクロリド

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Danger

• 危険有害性情報

  H314：重篤な皮膚の薬傷?眼の損傷

  H372：長期にわたる、または反復暴露により臓器の障 害

  H400：水生生物に強い毒性

• 注意書き

  P273：環境への放出を避けること。

  P280：保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。

  P303+P361+P353：皮膚（または髪）に付着した場合：直ちに汚染された衣 類をすべて脱ぐこと/取り除くこと。皮膚を流水/シャワー で洗うこと。

  P305+P351+P338：眼に入った場合：水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。

  P314：気分が悪い時は、医師の診断/手当てを受けること。

クロロアセチルクロリド 価格

クロロアセチルクロリド 化学特性,用途語,生産方法

• 外観

  無色～わずかにうすい黄色, 澄明の液体

• 溶解性

  水, アルコールに分解。エーテルに易溶。水及びエタノールで分解する。

• 用途

  医薬?染料中間体、クロロアセチル化剤

• 用途

  有機合成原料(クロロアセチル化剤)。

• 化学的特性

  Chloroacetyl chloride is a colorless to yellowish liquid with a very pungent, extremely irritating, odor.

• 使用

  Chloroacetyl chloride is an intermediate in the production of alachlor and butachlor. It is used to prepare phenacyl chloride through Friedel-Crafts acylation of benzene.

• 主な応用

  Chloroacetyl chloride can be used for chloroacetylation and chemical modification of poly(glycidyl methacrylate).
  Chloroacetyl chloride was used to study the in vitro metabolism of chloroacetamide herbicides by rat and human liver microsomes. Chloroacetyl chloride was used in the synthesis of some novel quinoline derivatives having antileishmanial activity.

• 製造方法

  Chloroacetyl chloride is usually manufactured from chloroacetic acid by reaction with phosphorus trichloride, thionyl chloride, sulfuryl chloride, or phosgene. It is also obtained by chlorination of acetyl chloride in the presence of stronger aliphatic acids, preferably chloroacetic acids, or from sodium chloroacetate and the usual chlorinating agents.
  Koenig G et al; Chloroacetic Acids. Ullmann's Encyclopedia of Industrial Chemistry 7th ed. (1999-2018). NY, NY: John Wiley & Sons. Online Posting Date: October 15, 2012

• 定義

  Chloroacetyl chloride is classified as an acyl halide. It is a colorless to light yellow liquid with a strong, pungent odor. This compound is highly toxic when inhaled and can corrode both metal surfaces and tissues.

• 一般的な説明

  A colorless to light yellow liquid with a very pungent odor. Very toxic by inhalation. Corrosive to metals and tissue.

• 反応プロフィール

  Chloroacetyl chloride reacts rapidly with water. Incompatible with strong oxidizing agents, alcohols, bases (including amines). May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].

• 危険性

  Irritant to eyes, corrosive to skin. Upper respiratory tract irritant.

• 健康ハザード

  Inhalation causes severe irritation of upper respiratory system. External contact causes severe irritation of eyes and skin. Ingestion causes severe irritation of mouth and stomach.

• 安全性プロファイル

  Poison by ingestion and intravenous routes. Mildly toxic by inhalation. Corrosive. A lachrymator. When heated to decomposition it emits toxic fumes of Cl-.

• 職業ばく露

  Highly toxic by inhalation. Chloroacetyl chloride is used in the manufacture of acetophenone. It is used in the manufacture of a number of pesticides including: alachlor, allidochlor, butachlor, dimethachlor, formothion, mecarbam, metolachlor, propachlor. It is also used in the manufacture of pharmaceuticals, such as chlordiazepoxide hydrochloride, diazepam, lidocaine, mianserin.

• 発がん性

  Chloroacetyl chloride was not genotoxic in a number of assays.

• 輸送方法

  UN1752 Chloroacetyl chloride, Hazard class: 6.1; Labels: 6.1-Poison Inhalation Hazard, 8-Corrosive material, Inhalation Hazard Zone B.

• 不和合性

  Reacts violently with water, steamforming chloroacetic acid and hydrogen chloride gas. Reacts with alcohols, powdered metals; sodium amide; combustibles; and many organics, causing toxic fumes, fire, and explosion hazard. On contact with air it emits corrosive gas. Decomposes when heated forming phosgene gas. Corrosive to metals.

• 廃棄物の処理

  It may be discharged into sodium bicarbonate solution, then flushed to the sewer with water.

クロロアセチルクロリド 上流と下流の製品情報

クロロアセチルクロリド 生産企業

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クロロアセチルクロリド スペクトルデータ(¹HNMR、¹³CNMR、IR、IR1、IR2、IR3、MS)

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