フルラゼパム

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Danger

• 危険有害性情報

  H225：引火性の高い液体および蒸気

  H370：臓器の障害

• 注意書き

  P210：熱/火花/裸火/高温のもののような着火源から遠ざ けること。－禁煙。

  P260：粉じん/煙/ガス/ミスト/蒸気/スプレーを吸入しないこ と。

  P280：保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。

  P301+P310：飲み込んだ場合：直ちに医師に連絡すること。

  P311：医師に連絡すること。

  P370+P378：火災の場合：消火に．．．を使用すること。

  P403+P235：換気の良い場所で保管すること。涼しいところに 置くこと。

フルラゼパム 価格

フルラゼパム 化学特性,用途語,生産方法

• 外観

  白色～うすい黄色, 結晶～粉末

• 溶解性

  クロロホルムに極めて溶けやすく、メタノール、エタノール、無水酢酸又はエーテルに溶けやすく、水にほとんど溶けない。エタノール(95)に溶けやすく、水にほとんど溶けない。

• 用途

  ベンゾジアゼピン系化合物で す。GABA 受容体に作用し、中枢神経抑制作 用を示します。作用時間は長時間です。

• 用途

  ベンゾジアゼピン系化合物で す。GABA受容体に作用し、中枢神経抑制作 用を示します。作用時間は長時間です。

• 用途

  動物実験、薬毒物試験の標準品。

• 効能

  催眠鎮静薬

• 説明

  Flurazepam (CRM) (Item No. 18160) is a certified reference material that is structurally categorized as a benzodiazepine. It acts as a partial agonist of the benzodiazepine site on GABA_A receptors, potentiating the action of GABA with an EC₅₀ value of 930 nM in neuronal chick spinal cord cultures. Through this signaling mechanism, flurazepam produces anxiolytic and sedative properties that have been implemented clinically in the treatment of insomnia but also carry a potential for misuse. This product is intended for forensic and research purposes.

• 化学的特性

  Flurazepam is a pale yellow crystalline solid.

• 使用

  Anticonvulsant; relaxant (muscle); sedative-hypnotic Dalmane (Valeant.

• 薬物動態学

  Chlorazepate is yet another benzodiazepine that is rapidly metabolized (3-decarboxylation) to N-desmethyldiazepam and so shares similar clinical and pharmacokinetic properties to chlordiazepoxide and diazepam.

• 副作用

  The half-life of flurazepam is fairly long (~7 hours); consequently, it has the same potential as chlordiazepoxide and diazepam to produce cumulative clinical effects and side effects (e.g., excessive sedation) and residual pharmacological activity, even after discontinuation.

• 安全性プロファイル

  Poison by intravenous routes. Moderately toxic by ingestion and subcutaneous routes. Experimental reproductive effects. Caution: May be habit forming. This is a controlled substance (depressant) listed in the US. Code of Federal Regulations, Title 21 Part 1308.14. When heated to decomposition it emits very toxic fumes of Cl-, Fand NOx. See also DIAZEPAM.

• 職業ばく露

  A Drug. Flurazepam is used as a seda tive in capsules or liquid form.

• 代謝

  Flurazepam is administered orally as the dihydrochloride salt. It is rapidly 1N-dealkylated to give the 2′-fluoro derivative of N-desmethyldiazepam, and it subsequently follows the same metabolic pathways as chlordiazepoxide and diazepam.

• 輸送方法

  UN3249 Medicine, solid, toxic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials.

• 廃棄物の処理

  It is inappropriate and possi bly dangerous to the environment to dispose of expired or waste drugs and pharmaceuticals by flushing them down the toilet or discarding them to the trash. Household quanti ties of expired or waste pharmaceuticals may be mixed with wet cat litter or coffee grounds, double-bagged in plastic, discard in trash. Larger quantities shall carefully take into consideration applicable DEA, EPA, and FDA regulations. If possible return the pharmaceutical to the manufacturer for proper disposal being careful to properly label and securely package the material. Alternatively, the waste pharmaceutical shall be labeled, securely packaged and transported by a state licensed medical waste contractor to dispose by burial in a licensed hazardous or toxic waste landfill or incinerator.

フルラゼパム 上流と下流の製品情報

17617-23-1, フルラゼパム キーワード