D-セリン

化学名:D-セリン

CAS番号.312-84-5

英語名:D-Serine

CBNumberCB0747387

MFC3H7NO3

MW105.09

MOL File312-84-5.mol

别名

D-セリン

(2R)-2-アミノ-3-ヒドロキシプロピオン酸

(R)-2-アミノ-3-ヒドロキシプロパン酸

D-セリン物理性質

融点	220 °C
沸点	197.09°C (rough estimate)
比旋光度	-14.75 º (c=10 2 N HCl)
比重(密度)	1.3895 (rough estimate)
屈折率	1.4368 (estimate)
貯蔵温度	Keep in dark place,Inert atmosphere,Room temperature
溶解性	H₂O: 0.1 g/mL 無色透明
酸解離定数(Pka)	2.16±0.10(Predicted)
外見	結晶性粉末
色	白い
水溶解度	346g/L（20℃）
Merck	14,8460
BRN	1721403
主な用途	細胞分析
InChI	1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
InChIKey	MTCFGRXMJLQNBG-UWTATZPHSA-N
SMILES	N[C@H](CO)C(O)=O
LogP	-1.490 (est)
CAS データベース	312-84-5(CAS DataBase Reference)
EPAの化学物質情報	D-Serine (312-84-5)

安全性情報

主な危険性	Xi
Rフレーズ	36/37/38
Sフレーズ	24/25-36-26
WGK Germany	3
RTECS 番号	VT8200000
TSCA	TSCA listed
HSコード	29225000
ストレージクラス	11 - Combustible Solids
化審法	届出不要化学物質

危険有害性情報のコード(GHS)

D-セリン価格

製品番号	包装	価格	製品説明	購入
富士フイルム和光純薬株式会社(wako) W01W0119-0882	1g	￥2950	D-セリン 99.0+% (Titration)	購入
富士フイルム和光純薬株式会社(wako) W01COBOR-0196	5g	￥10000	D-セリン	購入
富士フイルム和光純薬株式会社(wako) W01COBOR-0196	100g	￥25000	D-セリン	購入
東京化成工業 S0033	5g	￥3200	D-セリン >98.5%(T)	購入
東京化成工業 S0033	25g	￥9800	D-セリン >98.5%(T)	購入

MSDS Information

D-セリン化学特性,用途語,生産方法

外観
白色～ほとんど白色粉末～結晶
溶解性
水に溶けやすく、エタノール及びアセトンにほとんど溶けない。
用途
極性無電荷側鎖アミノ酸に分類され、グリシンなどから作り出せるため非必須アミノ酸である。糖原性を持つ。酵素の活性中心において、求核試薬として機能している場合がある。
説明
Serine is one of the 20 naturally-occurring amino acids used by all organisms in the biosynthesis of proteins. Having a single chiral center, serine can exist as one of two stereoisomers (L-Serine and D-Serine).
D-serine is categorized as a nootropic. It is an amino acid found in the brain and is produced primarily in astrocytes; the conversion of L-serine to D-serine is catalyzed by the serine racemase enzyme. D-serine acts as a co-agonist of glutamate NMDA receptors and binds at the glycine site. NMDA receptors mediate synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition, and learning. Schizophrenia is characterized by reduced NMDA receptor signaling and therefore, D-serine supplementation has been tested extensively in patients with schizophrenia. It is thought to improve cognitive symptoms in this population. It is worth noting that in Alzheimer’s disease, there is excess glutamate receptor activation. Memantine, one of the drugs used to treat Alzheimer’s disease, is an NMDA receptor antagonist.
化学的特性
D-serine is a off-white crystalline powder with a faint musty odor.It is an amino acid found in the brain. Derived from Glycine, d-serine is a neuromodulator, meaning it regulates the activities of neurons.

D-Serine supplementation can reduce symptoms of cognitive decline. It is also able to reduce symptoms of diseases characterized by reduced N-methyl-D-aspartate (NMDA) signaling, which includes cocaine dependence and schizophrenia.
使用
D-Serine is involved in the biosynthesis of purines, pyrimidines, and other amino acids. D-Serine also is an agonist of glycine site of the NMDA-type glutamate receptor. It also acts as Lacosamide intermediate.
定義
D-serine is the R-enantiomer of serine. It has a role as a NMDA receptor agonist, a human metabolite and an Escherichia coli metabolite. It is a D-alpha-amino acid and a serine. It is a conjugate base of a D-serinium. It is a conjugate acid of a D-serinate. It is an enantiomer of a L-serine. It is a tautomer of a D-serine zwitterion.
主な応用
D-serine has been used as a substrate in D-amino acid oxidase (DAO) activity in human 1321N1 astrocytoma cells. It has also been used in intracerebroventricular administration in rat for the induction of antinociceptive effect.
D-serine has been used to prevent glycine-dependent desensitization of N-methyl D-aspartate receptor (NMDAR) and to study its effects on NMDARs to correct behavioral abnormalities in rats after partial sciatic nerve ligation (PSNL).
一般的な説明
D-serine is an unusual amino acid expressed in the mammalian brain.
生物活性
D-serine is an agonist and glycine mimic which is active at the strychnine-insensitive glycine binding site associated with the N-methyl-D-aspartate (NMDA) receptor as well as the inhibitory post-synaptic glycine receptor. Along with glutamate, it has a role in various physiological processes including synaptic plasticity and receptor transmission. Dysregulation of D-serine signaling has been linked with neurodegenerative diseases and disorders.
D-serine is essential for the normal development of dendrites, neuroblast migration and may have therapeutic potential for treating schizophrenia and depression states. The levels of D-serine is elevated in traumatic brain injury (TBI).
作用機序
Within the CNS, D-serine can exert cell-type-specific inhibitory control. For instance, in the prefrontal cortex, D-serine differentially reduces the excitability of intratelencephalic (IT) neurons by recruiting small conductance Ca2+-activated K+ (SK) channels and suppresses burst firing in pyramidal tract (PT) neurons by slowing hyperpolarization-activated cyclic nucleotide-gated (HCN) channel kinetics^[1].

D-セリン

危険有害性情報のコード(GHS)

D-セリン価格

MSDS Information

D-セリン化学特性,用途語,生産方法

D-セリン上流と下流の製品情報

D-セリン生産企業

D-セリンスペクトルデータ(¹HNMR、IR1、IR2、MS、Raman)

312-84-5, D-セリンキーワード

D-セリン

危険有害性情報のコード(GHS)

D-セリン 価格

MSDS Information

D-セリン 化学特性,用途語,生産方法

D-セリン 上流と下流の製品情報

D-セリン 生産企業

D-セリン スペクトルデータ(1HNMR、IR1、IR2、MS、Raman)

312-84-5, D-セリン キーワード

D-セリン価格

D-セリン化学特性,用途語,生産方法

D-セリン上流と下流の製品情報

D-セリン生産企業

D-セリンスペクトルデータ(¹HNMR、IR1、IR2、MS、Raman)

312-84-5, D-セリンキーワード