レチノール酢酸エステル

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Danger

• 危険有害性情報

  H360：生殖能または胎児への悪影響のおそれ

  H413：長期的影響により水生生物に有害のおそれ

• 注意書き

  P201：使用前に取扱説明書を入手すること。

  P280：保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。

  P308+P313：暴露または暴露の懸念がある場合：医師の診断/手当てを 受けること。

レチノール酢酸エステル 価格

MSDS Information

• all-trans Vitamin A acetate

レチノール酢酸エステル 化学特性,用途語,生産方法

• 外観

  わずかにうすい黄色～黄赤色、結晶性粉末～粉末わずかにうすい黄色～黄赤色, 結晶性粉末～粉末

• 定義

  本品は、酢酸(*)とレチノール(*)のエステルである。
  参照表示名称：酢酸, レチノール

• 溶解性

  2-プロパノール溶状：本品50mg+2-プロパノール(→200ml)……澄明

• 無機性値/有機性値

  80/420

• 化粧品の成分用途

  皮膚コンディショニング剤

• 効能

  抗ニキビ薬, ビタミンA補充薬, レチノイン酸受容体(RAR)作動薬

• 使用上の注意

  不活性ガス封入

• 説明

  Retinyl acetate (retinol acetate, vitamin A acetate,127-47-9) is a natural form of vitamin A. It is the acetate ester of retinol. It consists of yellow crystals which are greasy or sticky. It has a mild, characteristic odor. It has potential antineoplastic and chemo-preventive activities. It can be used to fortify food with vitamin A. As vitamin A acetate can induce cell differentiation and inhibit cell proliferation, it is used in skin-conditioning agent.

• 化学的特性

  Retinyl acetate is a yellow, prism-shaped crystal and a lipid-soluble compound, with better chemical stability than vitamin A. In clinical practice, either vitamin A acetate or its palmitate form is typically dissolved in vegetable oil for administration, where it is hydrolyzed by enzymes in the body to release active vitamin A. The form of vitamin A listed in the Chinese Pharmacopoeia refers to the active vitamin A compound.

• 使用

  Retinyl acetate has been used:
  
  • a control diet to study its effect at different developmental periods in fish larvae
  • to study its inhibitory effects on Mycobacterium aviumsubspeciesparatuberculosis(MAP) strains
  • as an internal standard in high performance liquid chromatography (HPLC) to quantify vitamin A in fortified milk
  
  

• 製造方法

  A method for preparing retinyl acetate the following steps:
  Under alkaline conditions, 3-methyl-4-oxo-2-butene-1-yl acetate (referred to as C5 aldehyde ester) and tetraethyl methylene diphosphate undergo a condensation reaction to form an intermediate C6 phosphate (chemical name: 5-(diethyl phosphate)-3-methyl-2,4-hexadiene-1-acetate).
  Under alkaline conditions, the C6 phosphate undergoes a transposition reaction. C14 aldehyde (chemical name: 2-methyl-4-(2,6,6-trimethyl-1-cyclohexene-1-yl)-3-butene-1-aldehyde) is then added to undergo a Wittig-Horner condensation reaction, yielding retinyl acetate.

• 一般的な説明

  Retinyl acetate is suitable for use in the retention identification of the analyte when using HPLC and GC. Not intended for use as an activity reference standard. It has been thoroughly evaluated to ensure the utmost quality. Neat, unless otherwise noted. Certificate of Composition provided with the purchase.

• 安全性プロファイル

  Moderately toxic by ingestion. Experimental teratogenic and reproductive effects. Questionable carcinogen with experimental neoplastigenic data. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes. See also VITAMIN A.

• 純化方法

  The acetate is separated from retinol by column chromatography, then crystallised from MeOH. [Kofler and Rubin Vitamins and Hormones (NY) 18 315 1960 for purification methods]. Store it in the dark, under N2 or Ar, at 0o. [Beilstein 6 IV 4135.]

レチノール酢酸エステル 上流と下流の製品情報

レチノール酢酸エステル 生産企業

Global(739)Suppliers

レチノール酢酸エステル スペクトルデータ(¹HNMR、IR1)

127-47-9, レチノール酢酸エステル キーワード