エチドロン酸二ナトリウム

化学名:エチドロン酸二ナトリウム

CAS番号.7414-83-7

英語名:Etidronate disodium

CBNumberCB0207300

MFC2H9NaO7P2

MW230.02

别名

二ナトリウム＝二水素＝（１ヒドロキシエチリデン）ビス［ホスホナト］

エチドロン酸二ナトリウム水和物

1-ヒドロキシエタン-1,1-ジホスホン酸ナトリウム水和物

エチドロン酸二ナトリウム物理性質

融点	>300 °C
貯蔵温度	15-25°C
溶解性	H₂O: 26 mg/mL
外見	個体
色	白い
水溶解度	水に溶けます (26 mg/ml)。
Merck	14,3863
安定性：	Hygroscopic
CAS データベース	7414-83-7
EPAの化学物質情報	Phosphonic acid, (1-hydroxyethylidene)bis-, disodium salt (7414-83-7)

安全性情報

危険有害性情報のコード(GHS)

外観
白色～ほとんど白色粉末～結晶
効能
骨吸収抑制薬, 骨粗鬆症治療薬
商品名
ダイドロネル (大日本住友製薬)
説明
Agents in the first generation (e.g., etidronate disodium and tiludronate) that were dosed continuously produced poorly mineralized bone, because there was no interval for appropriate bone mineralization to occur. Subsequent studies that used a cyclic dosing schedule (400 mg/day for 2 weeks, followed by 2.5 months of calcium supplementation only) showed improvement in bone mineralization. Etidronate has been approved for treatment of Paget's disease of the bone but not for treatment of osteoporosis. Tiludronate is approximately 10-fold more potent than etidronate and, when given orally for 6 months (200, 400, or 800 mg/day), increases BMD by 2%. No further bone loss was detected in patients 6 months after cessation of therapy.
化学的特性
White Crystalline Solid
使用
Etidronate disodium is a bisphosphonate antiresorptive agent,it is used as a calcium regulator.
定義
ChEBI: An organic sodium salt resulting from the replacement of two protons from etidronic acid (one from from each of the phosphonic acid groups) by sodium ions.
安全性プロファイル
Poison by intravenous and subcutaneous routes. Moderately toxic by ingestion. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits toxic fumes of POx, and Na2O.