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6-Fluoro-4-(trifluoromethyl)-2(1H)-quinolinone

6-Fluoro-4-(trifluoromethyl)-2(1H)-quinolinone Structure
6-Fluoro-4-(trifluoromethyl)-2(1H)-quinolinone
  • CAS No.328956-08-7
  • Chemical Name:6-Fluoro-4-(trifluoromethyl)-2(1H)-quinolinone
  • CBNumber:CB92128695
  • Molecular Formula:C10H5F4NO
  • Formula Weight:231.15
  • MOL File:328956-08-7.mol
6-Fluoro-4-(trifluoromethyl)-2(1H)-quinolinone Property
  • Melting point 252-253 °C (decomp)(Solv: ethanol (64-17-5))
  • Boiling point 282 ºC
  • Density 1.468
  • Flash point 124 ºC
  • storage temp. 2-8°C
  • pka 9.33±0.70(Predicted)
  • InChI InChI=1S/C10H5F4NO/c11-5-1-2-8-6(3-5)7(10(12,13)14)4-9(16)15-8/h1-4H,(H,15,16)
  • InChIKey WUFRBOSKPZUGIS-UHFFFAOYSA-N
  • SMILES N1C2=C(C=C(F)C=C2)C(C(F)(F)F)=CC1=O
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

6-Fluoro-4-(trifluoromethyl)-2(1H)-quinolinone Chemical Properties,Usage,Production

  • Chemical Properties White solid
  • Description As a quinoline derivative, 6-Fluoro-4-hydroxy-2-(trifluoromethyl)quinoline is substituted with trifluoromethyl, hydroxyl, and fluoride groups. In particular, 6-Fluoro-4-hydroxy-2-(trifluoromethyl)quinoline can exist in a tautomeric form, known as quinolone, where the hydroxy group becomes a ketone and the imine changes to an amine. This compound is a precursor for synthesizing thioquinolines, which are used to develop non-cytotoxic, potent and selective antitubercular agents. The thiolation reaction is carried out using phosphorus pentasulfide in pyridine.
6-Fluoro-4-(trifluoromethyl)-2(1H)-quinolinone Preparation Products And Raw materials
Raw materials
Preparation Products
6-Fluoro-4-(trifluoromethyl)-2(1H)-quinolinone Suppliers
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6-Fluoro-4-(trifluoromethyl)-2(1H)-quinolinone Spectrum
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