ChemicalBook > CAS DataBase List > 4-Fluoroaniline

4-Fluoroaniline

CAS No.371-40-4
Chemical Name:4-Fluoroaniline
CBNumber:CB8143013
Molecular Formula:C6H6FN
Formula Weight:111.12
MOL File:371-40-4.mol

4-Fluoroaniline Property

Melting point -1.9 °C
Boiling point 187 °C/767 mmHg (lit.)
Density 1.173 g/mL at 25 °C (lit.)
refractive index n20/D 1.539(lit.)
Flash point 165 °F
storage temp. 2-8°C
solubility 33g/l
form Oily Liquid
pka 4.65(at 25℃)
color Clear pale yellow to red-brown
Specific Gravity 1.173
Water Solubility 33 g/L (20 ºC)
Merck 14,4169
BRN 742030
Stability Stable. Incompatible with acids, oxidizing agents.
CAS DataBase Reference 371-40-4(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII 60HI1G076Z
NIST Chemistry Reference p-Fluoroaniline(371-40-4)
EPA Substance Registry System p-Fluoroaniline (371-40-4)
UNSPSC Code 12352100
NACRES NA.22

Safety

Hazard Codes :C,T,Xi,Xn
Risk Statements :22-34-36/38-33-23/24/25
Safety Statements :26-36/37/39-45-37/39-28
RIDADR :UN 2941 6.1/PG 3
WGK Germany :1
RTECS :BY1575000
Hazard Note :Toxic/Irritant
TSCA :T
HazardClass :6.1
PackingGroup :III
HS Code :29214210
Hazardous Substances Data :371-40-4(Hazardous Substances Data)

NFPA 704:

	2
3		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordDanger
Hazard statements H302-H314-H373-H410
Precautionary statements P273-P280-P301+P312-P303+P361+P353-P305+P351+P338-P314

4-Fluoroaniline Price More Price(11)

Brand: Sigma-Aldrich(India)
Product number: F3800
Product name : 4-Fluoroaniline
Purity: 99%
Packaging: 25G
Price: ₹1948.5
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: F3800
Product name : 4-Fluoroaniline
Purity: 99%
Packaging: 100G
Price: ₹2208.3
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: F3800
Product name : 4-Fluoroaniline
Purity: 99%
Packaging: 500G
Price: ₹8551.75
Updated: 2022/06/14
Buy: Buy

Brand: ALFA India
Product number: ALF-A15597-36
Product name : 4-Fluoroaniline, 99%
Purity:
Packaging: 500g
Price: ₹9255
Updated: 2022/05/26
Buy: Buy

Brand: ALFA India
Product number: ALF-A15597-22
Product name : 4-Fluoroaniline, 99%
Purity:
Packaging: 100g
Price: ₹2806
Updated: 2022/05/26
Buy: Buy

4-Fluoroaniline Chemical Properties,Usage,Production

Chemical Properties 4-Fluoroaniline is a light yellow to gold-coloured liquid.It is easy to oxidize and turn red in air.
Uses 4-Fluoroaniline is a degradation product of Ezetimibe (E975000). 4-Fluoroaniline is used as an analytical reagent in the enzymic detection of glucose.
Uses 4-Fluoroaniline may be employed as one of the target pollutant during the investigation of biodegradability of fluorinated compounds under aerobic conditions. It may be used for the synthesis of luminescent and cationic monocyclometalated gold(III) monoaryl complexes.
Uses Intermediate in the manufacture of herbicides and plant growth regulators.
Preparation The better process in the one-step process is the nitrobenzene method, which is obtained by deoxygenation, hydrogenation and fluorination. With PdCl2-V2O5 as the catalyst and carbon monoxide as the reducing agent, the reaction was carried out at 160°C for 3h, and the yield of 4-fluoroaniline could reach 90%, with another 10% of aniline as a by-product. With PtO2 as the catalyst, BF3-HF as the fluorinating agent and hydrogen as the reducing agent, the reaction was carried out at 42℃ for 12.5h, with 100% conversion and 95% yield.
Definition ChEBI: 4-fluoroaniline is a primary arylamine that is the derivative of aniline in which the hydrogen at position 4 has been substituted by fluorine. It is used as an intermediate in the manufacture of pharmaceuticals, herbicides and plant growth regulators. It is a primary arylamine and a fluoroaniline.
Synthesis Reference(s) Journal of the American Chemical Society, 70, p. 654, 1948 DOI: 10.1021/ja01182a065
The Journal of Organic Chemistry, 26, p. 4014, 1961 DOI: 10.1021/jo01068a089
General Description 4-fluoroaniline is a light-colored oily liquid. Mixture of three isomers. Insoluble in water and denser than water. Contact may cause irritation to skin, eyes, and mucous membranes. May be toxic by ingestion. Used to make other chemicals. The barriers to inversion and internal rotation of the NH2 group in 4-fluoroaniline has been investigated by far infrared gas spectra.
Hazard Toxic material.
Flammability and Explosibility Not classified
Safety Profile Poison by ingestion. Mutation data reported. A severe skin and eye irritant. When heated to decomposition it emits very toxic fumes of NOx and F-.