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2-Hydroxy-4-(trifluoromethyl)quinoline

2-Hydroxy-4-(trifluoromethyl)quinoline Structure
2-Hydroxy-4-(trifluoromethyl)quinoline
  • CAS No.25199-84-2
  • Chemical Name:2-Hydroxy-4-(trifluoromethyl)quinoline
  • CBNumber:CB0496696
  • Molecular Formula:C10H6F3NO
  • Formula Weight:213.16
  • MOL File:25199-84-2.mol
2-Hydroxy-4-(trifluoromethyl)quinoline Property
  • Melting point >240°C
  • Boiling point 284 ºC
  • Density 1.391
  • Flash point 126 ºC
  • storage temp. Sealed in dry,Room Temperature
  • form Solid
  • color White
  • InChI InChI=1S/C10H6F3NO/c11-10(12,13)7-5-9(15)14-8-4-2-1-3-6(7)8/h1-5H,(H,14,15)
  • InChIKey UUROBWTVZZNDFD-UHFFFAOYSA-N
  • SMILES N1C2=C(C=CC=C2)C(C(F)(F)F)=CC1=O
  • CAS DataBase Reference 25199-84-2
Safety
  • Safety Statements  :24/25
  • HS Code  :29339900
  • NFPA 704:
    1
    2 0
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H315-H319-H335
  • Precautionary statements P261-P280a-P304+P340-P305+P351+P338-P405-P501a
2-Hydroxy-4-(trifluoromethyl)quinoline Price More Price(2)
  • Brand: ALFA India
  • Product number: ALF-H61732-MD
  • Product name : 4-Trifluoromethyl-2(1H)-quinolinone, 97%
  • Purity: 
  • Packaging: 250mg
  • Price: ₹3296
  • Updated: 2022/05/26
  • Buy: Buy
  • Brand: ALFA India
  • Product number: ALF-H61732-03
  • Product name : 4-Trifluoromethyl-2(1H)-quinolinone, 97%
  • Purity: 
  • Packaging: 1g
  • Price: ₹17505
  • Updated: 2022/05/26
  • Buy: Buy

2-Hydroxy-4-(trifluoromethyl)quinoline Chemical Properties,Usage,Production

  • Chemical Properties White solid
  • Synthesis 4-Trifluoromethylquinolin-2(1H)-one was prepared by reacting aniline and ethyl-4,4,4-trifluoroacetoacetate stirred in toluene.
    Experimental Procedure: In a 1 L round flask fitted with a reflux condenser a mixture of 25.60 g aniline, 50.0 g ethyl-4,4,4-trifluoroacetoacetate 300 ml toluene was heated to reflux in an oil bath at 130 °C. After 20 min 3 ml water was added and the mixture was heated at reflux for another 24 h. the reaction mixture was cooled to room temperature and concentrated under reduced pressure. A round flask with 200 mL H2SO4 was heated to 80°C and the crude oil from the step before was added in portions to the H2SO4 keeping the internal temperature below 90°C, total addition time was approximately 40 min. After addition was complete, the mixture was stirred at 80°C for 1 h, cooled and poured onto 400 g crushed ice. The resulting solids were filtered, washed with water, and dried under vacuum at 40°C to give 33.0 g (50%) product (2-Hydroxy-4-(trifluoromethyl)quinoline) as a colorless solid.
2-Hydroxy-4-(trifluoromethyl)quinoline Preparation Products And Raw materials
Raw materials
Preparation Products
2-Hydroxy-4-(trifluoromethyl)quinoline Suppliers
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2-Hydroxy-4-(trifluoromethyl)quinoline Spectrum
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  • BUTTPARK 33\04-80

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