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TRICHOSTATIN A

CAS No.58880-19-6
Chemical Name:TRICHOSTATIN A
CBNumber:CB8257301
Molecular Formula:C17H22N2O3
Formula Weight:302.37
MOL File:58880-19-6.mol

TRICHOSTATIN A Property

Melting point 140-143℃
alpha D20.5 +62.8° ±1.1° (c = 1.007 in ethanol)
Density 1.139
refractive index 136 ° (C=0.3, MeOH)
storage temp. -20°C
solubility ethanol: 1 mg/mL
pka 8.93±0.23(Predicted)
form Off-white lyophilized solid
color Tan
biological source Streptomyces sp.
Merck 14,9649
Stability Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
InChIKey ZWGICMNKJBUOHG-RCXLNATQSA-N
FDA UNII 3X2S926L3Z
NCI Drug Dictionary trichostatin A
UNSPSC Code 12352202
NACRES NA.77

Safety

Hazard Codes :Xn,Xi
Risk Statements :20/21/22-36/37/38-43
Safety Statements :26-36
RIDADR :NA 1993 / PGIII
WGK Germany :3
RTECS :MI5215000
HS Code :29280000

NFPA 704:

	0
3		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H302+H312+H332-H315-H317-H319-H335
Precautionary statements P261-P280-P305+P351+P338

TRICHOSTATIN A Price More Price(8)

Brand: Sigma-Aldrich(India)
Product number: V900931
Product name : Trichostatin A
Purity: Vetec?, reagent grade, from Streptomyces sp., ≥98%
Packaging: 1MG
Price: ₹21834.03
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: V900931
Product name : Trichostatin A
Purity: Vetec?, reagent grade, from Streptomyces sp., ≥98%
Packaging: 5MG
Price: ₹40041.68
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: T8552
Product name : Trichostatin A
Purity: ≥98% (HPLC), from Streptomyces sp.
Packaging: 1MG
Price: ₹24832.55
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: T8552
Product name : Trichostatin A
Purity: ≥98% (HPLC), from Streptomyces sp.
Packaging: 5MG
Price: ₹82811.25
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: T1952
Product name : Trichostatin A, Ready Made Solution
Purity: 5?mM in DMSO (0.2 μm-filtered), from Streptomyces sp.
Packaging: 200μL
Price: ₹7820.4
Updated: 2022/06/14
Buy: Buy

TRICHOSTATIN A Chemical Properties,Usage,Production

Description Trichostatin A (58880-19-6) is a potent and selective histone deacetylase (HDAC) inhibitor (Ki = 3.4 nM). Induces reversion of ras transformed cells to normal morphology. Trichostatin A induces dedifferentiation of primordial germ cells into embryonic germ cells. Cell permeable and active in vivo.
Chemical Properties Solid
Uses Trichostatin A, ready-made solution has been used:
- as a histone deacetylase inhibitor to study its effect on transcriptome changes by stem cell testing
- to inhibit histone deacetylase (HDAC) class I, II, or III in primary pituitary cell cultures and to investigate insulin control of endogenous human growth hormone gene (hGH)
- to treat cells for the HDAC inhibition experiments
Uses Trichostatin A is a histone deacetylase inhibitor that enhances the cytotoxic efficacy of anticancer drugs that target DNA. Trichostatin A displays antifungal, antiprotozoan and antitumour activity
Uses Trichostatin A is a known inhibitor of fibrosis in vitro and in vivo, and is used as an anticancer agent. Potent differentiation inducer of friend leukemic cells.
Definition ChEBI: Trichostatin A is an antibiotic antifungal agent, a trichostatin and a hydroxamic acid. It has a role as a bacterial metabolite, a geroprotector and an EC 3.5.1.98 (histone deacetylase) inhibitor. It is functionally related to a (R)-trichostatic acid.
General Description Trichostatin A is a compound of primary hydroxamic acid.
Biological Activity Selective and potent inhibitor of histone deacetylase (K i = 3.4 nM). Active in vivo . Potential anti-cancer agent. Induces accelerated dedifferentiation of primordial germ cells (PGCs) into embryonic germ (EG) cells.
Biochem/physiol Actions Inhibits histone deacetylase at nanomolar concentrations; resultant histone hyperacetylation leads to chromatin relaxation and modulation of gene expression. May be involved in cell cycle progression of several cell types, inducing cell growth arrest at both G and G/M phases; may induce apoptosis. Enhances the efficacy of anticancer agents that target DNA.
storage -20°C (desiccate)
References 1) Yoshida et al. (1990), Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A ; J. Biol. Chem., 265 17174 2) Futamura et al. (1995), Trichostatin A inhibits both ras-induced neurite outgrowth of PC12 cells and morphological transformation of NIH3T3 cells; Oncogene, 10 1119 3) Durcova-Hills et al. (2008), Reprogramming Primordial Germ Cells into Pluripotent Stem Cells; PLoS-One, 3 e3531