ChemicalBook > CAS DataBase List > M344

M344

M344 Structure
M344
  • CAS No.251456-60-7
  • Chemical Name:M344
  • CBNumber:CB0673778
  • Molecular Formula:C16H25N3O3
  • Formula Weight:307.39
  • MOL File:251456-60-7.mol
M344 Property
  • Melting point 161℃
  • Density 1.137±0.06 g/cm3(Predicted)
  • storage temp. 2-8°C
  • solubility DMSO: soluble10mg/mL, clear
  • pka 9.48±0.20(Predicted)
  • form White solid
  • color white to beige
  • Sensitive Light Sensitive
  • CAS DataBase Reference 251456-60-7
  • FDA UNII J8W4VF5ZEJ
  • UNSPSC Code 12352200
  • NACRES NA.77
Safety
  • WGK Germany  :3
  • HS Code  :2928.00.2500
  • NFPA 704:
    0
    1 0
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H315-H319-H335
  • Precautionary statements P261-P302+P352-P305+P351+P338-P321-P405-P501
M344 Price More Price(5)
  • Brand: Sigma-Aldrich(India)
  • Product number: M5820
  • Product name : M344
  • Purity: ≥98% (HPLC), powder
  • Packaging: 1MG
  • Price: ₹19658.2
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: M5820
  • Product name : M344
  • Purity: ≥98% (HPLC), powder
  • Packaging: 5MG
  • Price: ₹77885.88
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: 382149
  • Product name : Histone Deacetylase Inhibitor III
  • Purity: The Histone Deacetylase Inhibitor III, also referenced under CAS 251456-60-7, controls the biological activity of Histone Deacetylase. This small mole
  • Packaging: 1MG
  • Price: ₹17860
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: TCI Chemicals (India)
  • Product number: D4188
  • Product name : 4-(Dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide
  • Purity: 
  • Packaging: 20MG
  • Price: ₹5600
  • Updated: 2022/05/26
  • Buy: Buy
  • Brand: TCI Chemicals (India)
  • Product number: D4188
  • Product name : 4-(Dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide
  • Purity: 
  • Packaging: 100MG
  • Price: ₹19600
  • Updated: 2022/05/26
  • Buy: Buy

M344 Chemical Properties,Usage,Production

  • Uses Histone deacetylase inhibitor III. A cell-permeable amide analog of Trichostatin A that potently inhibits HDACs.
  • Uses M 344 is an inhibitor of histone deacetylases (HDACs), inhibiting maize HDAC (IC50 = 100 nM) as well as human HDAC1 (IC50 = 46 nM). It shows a three-fold selectivity for inhibition of HDAC6 over HDAC1. M 344 enhances the sensitivity of human squamous carcinoma cells to radiation and promotes cell cycle arrest and apoptosis in human endometrial cancer and ovarian cancer cells (ED50 = 2.3 μM).
  • Definition ChEBI: 4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide is a benzamide resulting from the formal condensation of the carboxy group of 4-(dimethylamino)benzoic acid with the amino group of 7-amino-N-hydroxyheptanamide. It is a potent inhibitor of histone deacetylases and induces cell cycle arrest and apoptosis in several human cancer cell lines. It has a role as an apoptosis inducer, an antineoplastic agent and an EC 3.5.1.98 (histone deacetylase) inhibitor. It is a member of benzamides, a hydroxamic acid, a secondary carboxamide and a tertiary amino compound.
  • General Description A cell-permeable amide analog of Trichostatin A (Cat. No. 647925) that potently inhibits histone deacetylases (IC50 = 40 nM for rat liver HDAC and IC50 = 100 nM for maize HD). Induces differentiation and inhibits proliferation (~2 μM) of murine erythroleukemia cells.
  • Biological Activity Histone deacetylase inhibitor (IC 50 = 100 nM). Induces terminal cell differentiation and causes an increase in hyperacetylated histone H4. Antiproliferative agent; suppresses the growth of human endometrial and ovarian cancer cells by inducing cell cycle arrest and apoptosis.
  • Biochem/physiol Actions Cell permeable: yes
  • References [1]. jung m, brosch g , kolle d, et al. amide analogues of trichostatin a as inhibitors of histone deacetylase and inducers of terminal cell differentiation. journal of medicinal chemistry, 1999, 42 (22): 4669-4679.
    [2]. yeung a, bhargava rk, ahn, r, et al. hdac inhibitor m344 suppresses mcf-7 breast cancer cell proliferation. biomedicine & pharmacotherapy, 2012, 66 (3): 232-236.
    [3]. furchert se, lanvers-kaminsky c , jurgens h , et al. inhibitors of histone deacetylases as potential therapeutic tools for high-risk embryonal tumors of the nervous system of childhood. international journal of cancer, 2007, 120 (8): 1787-1794.
    [4]. ying h, zhang yh , zhou x , et al. selective histonedeacetylase inhibitor m344 intervenes in hiv-1 latency through increasing histone acetylation and activation of nf-kappab. plos one, 2012, 7 (11): e48832.
M344 Preparation Products And Raw materials
Raw materials
Preparation Products
M344 Suppliers
Global(146)Suppliers
  • Supplier：
    BOC Sciences
  • Tel：+1-631-485-4226
  • Email：inquiry@bocsci.com
  • Country：United States
  • ProdList：19552
  • Advantage：58
  • Supplier：
    Alchem Pharmtech,Inc.
  • Tel：8485655694
  • Email：sales@alchempharmtech.com
  • Country：United States
  • ProdList：63687
  • Advantage：58
  • Supplier：
    career henan chemical co
  • Tel：+86-0371-86658258<br/>+8613203830695
  • Email：factory@coreychem.com
  • Country：China
  • ProdList：29808
  • Advantage：58
  • Supplier：
    TargetMol Chemicals Inc.
  • Tel：+1-781-999-5354<br/>+1-00000000000
  • Email：marketing@targetmol.com
  • Country：United States
  • ProdList：32202
  • Advantage：58
  • Supplier：
    InvivoChem
  • Tel：+1-708-310-1919<br/>+1-13798911105
  • Email：sales@invivochem.cn
  • Country：United States
  • ProdList：6391
  • Advantage：58
M344 Spectrum
251456-60-7, M344Related Search:
  • Apoptosis Inducers
  • Inhibitor
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • Inhibitors
  • Aromatics
  • Amines
  • 抑制剂
  • 生化试剂
  • 药靶配体
  • 标准品
  • 细胞生物学试剂
  • 细胞骨架信号
  • 小分子抑制剂，天然产物
  • 小分子抑制剂
  • Cell Biology
  • Cell Signaling and Neuroscience
  • BioChemical
  • Gene Regulation and Expression
  • DNA-RNA Transcription Regulators
  • 51456-60-7
  • 化合物HISTONE DEACETYLASE INHIBITOR III,10 MM DMSO 溶液
  • M344,HDAC抑制剂
  • 4-(二甲氨基)-N-(7-羟基氨基-7-氧代庚基)苯甲酰胺
  • 化合物HISTONE DEACETYLASE INHIBITOR III
  • 4-(二甲氨基)-N-[7-(羟基氨基)-7-氧庚]苯甲酰胺
  • 4-二甲基氨基-N-(6-羟基氨基甲酰己基)苯甲酰胺
  • 组蛋白去乙酰化酶抑制剂(M 344)
  • 4-(二甲氨基)-N-[7-(羟基氨基)-7-氧庚]苯甲酰胺(组蛋白去乙酰化酶抑制剂)
  • 251456-60-7
  • 7-{[4-(Dimethylamino)phenyl]formamido}-N-hydroxyheptanamide
  • M344, 10 mM in DMSO
  • M344, HDAC inhibitor
  • M344 HDAC inhibitor M-344 Histone Deacetylase Inhibitor III
  • Histone Deacetylase Inhibitor III(M344)
  • CS-661
  • HISTONE DEACETYLASE INHIBITOR III;D237;D 237;D-237;M-344;M344
  • M344 USP/EP/BP
  • Benzamide, 4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]-
  • 4-(Dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide&gt
  • M344 (D 237)
  • MS 344, D237
  • 4-(Diethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide
  • M 344 (enzyme inhibitor)
  • MS 344
  • 4-(Dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]-benzamide
  • 4-(Dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]-benzamide, MS 344, D237, N-Hydroxy-7-(4-dimethylaminobenzoyl)-aminoheptanamide
  • N-HYDROXY-7-(4-DIMETHYLAMINOBENZOYL)AMINOHEPTANAMIDE
  • 4-DIMETHYLAMINO-N-(6-HYDROXYCARBAMOYLHEXYL)-BENZAMIDE
  • HISTONE DEACETYLASE INHIBITOR III
  • M344

Home

My