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JNJ-26481585

JNJ-26481585 Structure
JNJ-26481585
  • CAS No.875320-29-9
  • Chemical Name:JNJ-26481585
  • CBNumber:CB42500942
  • Molecular Formula:C21H26N6O2
  • Formula Weight:394.47
  • MOL File:875320-29-9.mol
JNJ-26481585 Property
  • Density 1.35
  • storage temp. Store at -20°C
  • solubility insoluble in H2O; insoluble in EtOH; ≥19.2 mg/mL in DMSO
  • form Powder
  • color Off-white to yellow
  • FDA UNII 9BJ85K1J8S
  • NCI Drug Dictionary quisinostat
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

JNJ-26481585 Chemical Properties,Usage,Production

  • Uses JNJ-26481585 is an HDAC1, HDAC2, HDAC4, HDAC10, and HDAC11 inhibitor. Potent Histone deacetylase inhibitor.
  • Definition ChEBI: N-hydroxy-2-[4-[[(1-methyl-3-indolyl)methylamino]methyl]-1-piperidinyl]-5-pyrimidinecarboxamide is a member of indoles.
  • Biological Activity jnj-26481585 is a novel histone deacetylase (hdac) inhibitor that exerts a strong potency towards class i hdac (including hdac1, hdac2 and hdac3), with values of inhibition constant ic50 of 0.11, 0.33 and 4.8 nmol/l respectively, leading to strong anti-proliferative activities (ic50 ranging from 3.1 to 246 nmol/l) against a broad range of cancer cell lines including lung, breast, colon, prostate, brain and overian cancer cell lines. recent study results have shown that jnj-26481585 strongly induce the hdac1-suppressed p21waf1,cip1 promoter in vivo, histone h3 acetylation in tumor tissue and apoptosis in human colon cancer cell lines (both apc wild-type and mutant) in vitro.arts j, king p, mariën a, floren w, beliën a, janssen l, pilatte i, roux b, decrane l, gilissen r, hickson i, vreys v, cox e, bol k, talloen w, goris i, andries l, du jardin m, janicot m, page m, van emelen k, angibaud p. jnj-26481585, a novel "second-generation" oral histone deacetylase inhibitor, shows broad-spectrum preclinical antitumoral activity. clin cancer res. 2009;15(22):6841-6851
  • in vivo

    Quisinostat (40 mg/kg; p.o.; once daily; for 3 days) acts as a potent HDAC1 inhibitor that inhibits p21waf1,cip1 ZsGreen tumors in vivo[1].
    ? Quisinostat induces continuous H3 acetylation in tumor tissue in vivo[1].
    ? Quisinostat (10 mg/kg; once daily; i.p.; for 14 days) strongly inhibits the growth of large pre-established HCT116 colon xenografts[1].

    Animal Model:NMRI nude mice, with HCT116 colon carcinoma cells xenografts[1]
    Dosage:10 mg/kg
    Administration:Intraperitoneal injection, once daily, for 14 days
    Result:Strongly inhibited the growth of large pre-established HCT116 colon xenografts.
  • target HDAC1
  • IC 50 HDAC1: 0.11 nM (IC50); HDAC2: 0.33 nM (IC50); HDAC4: 0.64 nM (IC50); HDAC10: 0.46 nM (IC50); HDAC11: 0.37 nM (IC50); HDAC3: 4.86 nM (IC50); HDAC5: 3.69 nM (IC50); HDAC8: 4.26 nM (IC50); HDAC9: 32.1 nM (IC50); HDAC6: 76.8 nM (IC50); HDAC7: 119 nM (IC50)
JNJ-26481585 Preparation Products And Raw materials
Raw materials
Preparation Products
JNJ-26481585 Suppliers
Global(107)Suppliers
  • Supplier：
    InvivoChem
  • Tel：+1-708-310-1919<br/>+1-13798911105
  • Email：sales@invivochem.cn
  • Country：United States
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    LEAP CHEM CO., LTD.
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  • Supplier：
    TargetMol Chemicals Inc.
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  • Email：support@targetmol.com
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  • Supplier：
    Henan Fengda Chemical Co., Ltd
  • Tel：+86-371-86557731<br/>+86-13613820652
  • Email：info@fdachem.com
  • Country：China
  • ProdList：20235
  • Advantage：58
JNJ-26481585 Spectrum
875320-29-9, JNJ-26481585Related Search:
  • Inhibitor
  • Inhibitors
  • 生物试剂
  • 标准品
  • 细胞生物学试剂
  • 抑制剂
  • 小分子抑制剂，天然产物
  • 奎诺司他,10 MM DMSO 溶液
  • QUISINOSTAT游离
  • HDAC抑制剂(QUISINOSTAT)
  • N-羟基-2-[4-[[[(1-甲基-1H-吲哚-3-基)甲基]氨基]甲基]-1-哌啶基]-5-嘧啶甲酰胺
  • 奎诺司他
  • -羟基-2-[4-[[[(1-甲基-1H-吲哚-3-基)甲基]氨基]甲基]-1-哌啶基]-5-嘧啶甲酰胺
  • N1-(2-(1H-吲哚-3-基)乙基)-N4-(吡啶-4-基)苯-1,4-二胺
  • 875320-29-9
  • JNJ-26481585 (Quisinostat)
  • Quisinostat, 10 mM in DMSO
  • JNJ-26481585 JNJ26481585 Quisinostat
  • 5-Pyrimidinecarboxamide, N-hydroxy-2-[4-[[[(1-methyl-1H-indol-3-yl)methyl]amino]methyl]-1-piperidinyl]-
  • Quisinostat HClbase
  • N-hydroxy-2-[4-[[(1-methylindol-3-yl)methylamino]methyl]piperidin-1-yl]pyrimidine-5-carboxamide
  • JNJ26481585;JNJ 26481585
  • CS-1098
  • Quisinostat (JNJ-26481585) 2HCl
  • N-Hydroxy-2-(4-((((1-methyl-1H-indol-3-yl)methyl)amino)-methyl)piperidin-1-yl)pyrimidine-5-car
  • Quisinostat
  • Quisinostat (JNJ-26481585)
  • N-Hydroxy-2-(4-((((1-Methyl-1H-indol-3-yl)Methyl)aMino)Methyl)piperidin-1-yl)pyriMidine-5-carboxaMide
  • N-Hydroxy-2-(4-((((1-methyl-1H-indol-3-yl)methyl)amino)-methyl)piperidin-1-yl)pyrimidine-5-carbox
  • N-Hydroxy-2-[4-[[[(1-methyl-1H-indol-3-yl)methyl]amino]methyl]-1-piperidinyl]-5-pyrimidinecarboxamide
  • N1-(2-(1H-indol-3-yl)ethyl)-N4-(pyridin-4-yl)benzene-1,4-diaMine
  • JNJ-26481585

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