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JNJ-7706621

JNJ-7706621 Structure
JNJ-7706621
  • CAS No.443797-96-4
  • Chemical Name:JNJ-7706621
  • CBNumber:CB62484646
  • Molecular Formula:C15H12F2N6O3S
  • Formula Weight:394.36
  • MOL File:443797-96-4.mol
JNJ-7706621 Property
  • Melting point 149-155℃
  • Boiling point 676.6±65.0 °C(Predicted)
  • Density 1.71
  • storage temp. +2C to +8C
  • solubility Soluble in DMSO at 15mg/ml
  • form White solid
  • pka 9.80±0.12(Predicted)
  • color White to off-white
  • Sensitive Light Sensitive
  • FDA UNII 74GK72DON8
  • UNSPSC Code 12352202
  • NACRES NA.54
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302-H315-H319-H335
  • Precautionary statements P261-P280a-P304+P340-P305+P351+P338-P405-P501a
JNJ-7706621 Price More Price(1)
  • Brand: Sigma-Aldrich(India)
  • Product number: 189406
  • Product name : Aurora Kinase/Cdk Inhibitor - CAS 443797-96-4 - Calbiochem
  • Purity: The Aurora Kinase/Cdk Inhibitor, also referenced under CAS 443797-96-4, controls the biological activity of Aurora Kinase/Cdk. This small molecule/inh
  • Packaging: 5MG
  • Price: ₹33440
  • Updated: 2022/06/14
  • Buy: Buy

JNJ-7706621 Chemical Properties,Usage,Production

  • Description JNJ-7706621 is a dual inhibitor of cyclin-dependent kinases (CDKs) and Aurora kinases. It potently inhibits Cdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, Cdk3/cyclin E, Cdk4/cyclin D1, Cdk6/cyclin D1, Aurora A, and Aurora B in vitro (IC50s = 9, 4, 3, 58, 253, 175, 11, and 15 nM, respectively). It shows selectivity for these enzymes over a panel of other receptors and kinases, although it exhibits submicromolar inhibition of VEGF and FGF receptors, as well as GSK3β. JNJ-7706621 blocks the growth of a large variety of cancer cell lines (IC50 values range from 112 to 514 nM), with lower potency against normal cells (IC50 values between 3.67 and 5.42 μM). It induces the regression of A375 melanoma human tumor xenografts in mice. JNJ-7706621 is a substrate for the ATP-binding cassette transporter G2, also known as breast cancer resistance protein.
  • Uses JNJ-770662 is a broad spectrum inhibitor of cyclin-dependent kinases and aurora kinases including CDK1/Cyclin B, CDK2/Cyclin A, CDK2/Cyclin E, Aurora-A and Aurora-B. JNJ-770662 has been shown to induce growth suppression and mitotic defects, these results suggest that JNJ-7706621 could be useful for cell cycle analysis and therapy of various cancers, including Ewing''s sarcoma.
  • Definition ChEBI: 4-[[5-amino-1-[(2,6-difluorophenyl)-oxomethyl]-1,2,4-triazol-3-yl]amino]benzenesulfonamide is a sulfonamide.
  • in vivo

    JNJ-7706621 (100 and 125 mg/kg) is efficacious in a human tumor xenograft model under intermittent dosing regimens[3]. JNJ-7706621 (100 mg/kg, i.p.) exhibits 95% tumor growth inhibition in A375 (human melanoma) tumor xenograft model[1]. JNJ-7706621-loaded micelles inhibit tumor growth, and delay the tumor growth more efficiently than the control JNJ-7706621 suspension[4].

  • target CDK1
  • IC 50 CDK6/cyclinD1: 175 nM (IC50); CDK2/cyclinE: 3 nM (IC50); Cdk4/cyclin D1: 253 nM (IC50); Cdk1/cyclin B: 9 nM (IC50); cdk2/cyclin A: 4 nM (IC50); CDK3/Cyclin E: 58 nM (IC50); Aurora A: 11 nM (IC50); Aurora B: 15 nM (IC50); VEGF-R2: 154 nM (IC50); VEGF-R1: 6400 nM (IC50); VEGF-R3: 735 nM (IC50); FGF-R1: 575 nM (IC50); FGF-R2: 226 nM (IC50); GSK3β: 254 nM (IC50)
JNJ-7706621 Preparation Products And Raw materials
Raw materials
Preparation Products
JNJ-7706621 Suppliers
Global(131)Suppliers
  • Supplier：
    Capot Chemical Co.,Ltd.
  • Tel：+86-（0）57185586718<br/>+86-13336195806
  • Email：sales@capot.com
  • Country：China
  • ProdList：29730
  • Advantage：60
  • Supplier：
    TargetMol Chemicals Inc.
  • Tel：+1-781-999-5354<br/>+1-00000000000
  • Email：marketing@targetmol.com
  • Country：United States
  • ProdList：32159
  • Advantage：58
  • Supplier：
    Career Henan Chemica Co
  • Tel：+86-0371-86658258<br/>+8613203830695
  • Email：laboratory@coreychem.com
  • Country：China
  • ProdList：30231
  • Advantage：58
JNJ-7706621 Spectrum
443797-96-4, JNJ-7706621Related Search:
  • JNJ-7706621
  • Inhibitors
  • Inhibitor
  • 抑制剂
  • 拉泽替尼
  • 合成有机化合物配体
  • 药靶配体
  • 科研出口
  • 细胞周期
  • 小分子抑制剂，天然产物
  • C15H12F2N6O3S
  • 化合物JNJ7706621,10 MM DMSO 溶液
  • JNJ-7706621,泛CDK抑制剂
  • 化合物JNJ7706621
  • 拉泽替尼
  • 4-[[5-氨基-1-(2,6-二氟苯甲酰基)-1H-1,2,4-三唑-3-基]氨基]苯磺酰胺
  • 443797-96-4
  • JNJ-7706621, 10 mM in DMSO
  • Cyclin dependent kinase,CDK,JNJ-7706621,Apoptosis,JNJ7706621,inhibit,Inhibitor,Aurora Kinase
  • JNJ-7706621 JNJ7706621 Aurora Kinase Cdk Inhibitor
  • JNJ-7706621 USP/EP/BP
  • 4-[[5-Amino-1-(2,6-difluorobenzoyl)-1,2,4-triazol-3-yl]amino]benzenesulfonamide
  • Benzenesulfonamide, 4-[[5-amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazol-3-yl]amino]-
  • JNJ7706621; JNJ 7706621
  • CS-409
  • Aurora Kinase/Cdk Inhibitor - CAS 443797-96-4 - Calbiochem
  • Aurora Kinase/Cdk Inhibitor
  • 4-[[5-Amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazol-3-yl]amino]benzenesulfonamide
  • 4-[[5-Amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazol-3-yl]amino]benzenesulfonamide JNJ7706621

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