ChemicalBook > CAS DataBase List > CCT129202

CCT129202

CCT129202 Structure
CCT129202
  • CAS No.942947-93-5
  • Chemical Name:CCT129202
  • CBNumber:CB02561464
  • Molecular Formula:C23H25ClN8OS
  • Formula Weight:497.02
  • MOL File:942947-93-5.mol
CCT129202 Property
  • Density 1.427
  • storage temp. Store at -20°C
  • solubility DMSO : 1 mg/mL (2.01 mM; Need ultrasonic)
  • form Powder
  • pka 9.26±0.50(Predicted)
  • color Light yellow to yellow
  • FDA UNII 8N349V9Q27
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302-H315-H319-H335
  • Precautionary statements P261-P264-P270-P271-P280-P301+P312-P330-P302+P352-P321-P304+P340-P305+P351+P338-P332+P313-P362+P364-P337+P313-P403+P233-P405-P501

CCT129202 Chemical Properties,Usage,Production

  • Uses CCT129202 is an aurora kinase inhibitor with IC50s of 42, 198, and 227 nM for aurora A, B and C, respectively.
  • Biological Activity CCT129202 is an ATP-competitive pan-Aurora inhibitor with IC50s of 0.042 μM, 0.198 μM and 0.227 μM for Aurora A, Aurora B and Aurora C, respectively, and has a weaker effect on FGFR3, GSK3β, PDGFRβ, etc.
  • in vivo CCT129202 at a dose of 100 mg/kg subcutaneously injected HCT116 colon xenografts in athymic mice, after 30 minutes, caused a ~50% decrease in histone H3 phosphorylation, and after 9 days of treatment, significantly inhibited tumor growth, compared with the control group , inhibited by 57.7%.
  • target Aurora A
  • IC 50 Aurora A: 42 nM (IC50); Aurora B: 198 nM (IC50); Aurora C: 227 nM (IC50)
  • References [1] Chan F, et al. Mechanism of action of the Aurora kinase inhibitor CCT129202 and in vivo quantification of biological activity. Mol Cancer Ther. 2007 Dec;6(12 Pt 1):3147-57. DOI:10.1158/1535-7163.MCT-07-2156
CCT129202 Preparation Products And Raw materials
Raw materials
Preparation Products
CCT129202 Suppliers
Global(104)Suppliers
  • Supplier：
    career henan chemical co
  • Tel：+86-0371-86658258<br/>+8613203830695
  • Email：factory@coreychem.com
  • Country：China
  • ProdList：29808
  • Advantage：58
  • Supplier：
    TargetMol Chemicals Inc.
  • Tel：+1-781-999-5354<br/>+1-00000000000
  • Email：marketing@targetmol.com
  • Country：United States
  • ProdList：32159
  • Advantage：58
  • Supplier：
    InvivoChem
  • Tel：+1-708-310-1919<br/>+1-13798911105
  • Email：sales@invivochem.cn
  • Country：United States
  • ProdList：6391
  • Advantage：58
  • Supplier：
    TargetMol Chemicals Inc.
  • Tel：
  • Email：support@targetmol.com
  • Country：United States
  • ProdList：38630
  • Advantage：58
  • Supplier：
    LEAPCHEM CO., LTD.
  • Tel：+86-852-30606658
  • Email：market18@leapchem.com
  • Country：China
  • ProdList：43340
  • Advantage：58
CCT129202 Spectrum
942947-93-5, CCT129202Related Search:
  • Inhibitors
  • Inhibitor
  • 生物化学试剂
  • 抑制剂
  • 化学中间体
  • 药靶配体
  • 细胞生物学试剂
  • 小分子抑制剂，天然产物
  • 细胞周期
  • C23H25ClN8OS
  • 化合物 CCT129202
  • 化合物XL147 ANALOGUE
  • AURORA A/AURORA B和AURORA C抑制剂(CCT129202)
  • 2-[4-[6-氯-2-(4-二甲基氨基苯基)-3H-咪唑并[4,5-B]吡啶-7-基]哌嗪-1-基]-N-(噻唑-2-基)乙酰胺
  • 942947-93-5
  • 1-Piperazineacetamide, 4-[6-chloro-2-[4-(dimethylamino)phenyl]-3H-imidazo[4,5-b]pyridin-7-yl]-N-2-thiazolyl-
  • CCT129202 USP/EP/BP
  • CS-407
  • CCT129202 (CCT-129202
  • 2-(4-(6-Chloro-2-(4-(dimethylamino)phenyl)-1H-imidazo[4,5-b]pyridin-7-yl)piperazin-1-yl)-N-(th
  • 2-[4-[6-Chloro-2-(4-dimethylaminophenyl)-3H-imidazo[4,5-b]pyridin-7-yl]piperazin-1-yl]-N-(thiazol-2-yl)acetamide
  • CCT129202

Home

My