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Linifanib (ABT-869)

Linifanib (ABT-869) Structure
Linifanib (ABT-869)
  • CAS No.796967-16-3
  • Chemical Name:Linifanib (ABT-869)
  • CBNumber:CB52464951
  • Molecular Formula:C21H18FN5O
  • Formula Weight:375.4
  • MOL File:796967-16-3.mol
Linifanib (ABT-869) Property
  • Melting point 180-183°C (dec.)
  • Boiling point 542.2±50.0 °C(Predicted)
  • Density 1.424
  • storage temp. -20°C Freezer
  • solubility DMSO, Methanol
  • pka 13.30±0.70(Predicted)
  • form Brown powder.
  • color Beige
  • NCI Dictionary of Cancer Terms ABT-869
  • FDA UNII CO93X137CW
  • NCI Drug Dictionary linifanib
Safety
  • HS Code  :2933998090
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements H410-H372-H361-H400
  • Precautionary statements P273-P391-P501-P273-P391-P501-P260-P264-P270-P314-P501-P201-P202-P281-P308+P313-P405-P501

Linifanib (ABT-869) Chemical Properties,Usage,Production

  • Chemical Properties Beige Solid
  • Uses Linifanib (ABT 869) is an oral tyrosine kinase inhibitor with antineoplasic activity. As a dual inhibitor, Linifanib, is being tested on several different cancers.
  • Uses Linifanib (ABT-869) is a novel, potent ATP-competitive RTK inhibitor for KDR, CSF-1R, Flt-1, Flt-3 and PDGFRβ with IC50 of 4 nM, 3 nM, 3 nM, 3 nM, and 66 nM respectively.
  • Definition ChEBI: A member of the class of ureas that is urea in which one of the nitrogens is substituted by a 2-fluoro-5-methylphenyl group, while the other nitrogen is substituted by a p-(3-amino-1H-indazol-4-yl)phenyl group. It is a poten , selective inhibitor of vascular endothelial growth factor and platelet-derived growth factor receptor tyrosine kinases.
  • Biological Activity linifanib (abt-869) is an effective atp-competitive tyrosine kinase inhibitor against the platelet-derived growth factor (pdgf) receptor and the vascular endothelial growth factor receptor (vegfr) families, including constitutively active fms-like receptor tyrosine kinase 3 (flt3) [1][2]. it is of ic50 values of 0.55 nmol/l and 6 μmol/l to the cell growth in ba/f3 flt3 itd mutant cells and in ba/f3 flt3 wt cells, respectively [1].flt3 is important in controlling the proliferation and differentiation of hematopoietic cells. patients with acute myeloid leukemia (aml) showed activating mutations in flt3. these mutations caused abnormal cell proliferation [1].linifanib at a concentration of 10 nmol/l induced apoptosis in internal tandem duplication (itd) mutant cells, but showed no effect in wt cells. treatment with linifanib did not differentiate wt cells from flt3 mutant cells with mutation at d835v, in inhibiting proliferation or reducing cell viability. in ba/f3 flt3 itd cell lines, linifanib at a concentration of 10 nmol/l, effectively inhibited the phosphorylation of flt3. 10 nmol/l linifanib reduced the phosphorylation of akt at ser473 [1].daily orally treatment with linifanib by gavage in nod/scid mice with itd mutant cell decreased the leukemia progression rate compared with the control. on day 7, itd mutant cells showed rapid progression in control mice, whereas linifanib-treated mice showed no detectable disease. in addition, daily linifanib-treated mice with itd mutant cells showed significantly longer (p < 0.01) survival duration than control mice with itd mutant cells only [1].
  • target VEGFR1/FLT1
  • storage Store at -20°C
  • References [1]. jenny e. hernandez-davies, joan p. zape, elliot m. landaw, et al. the multitargeted receptor tyrosine kinase inhibitor linifanib (abt-869) induces apoptosis through an akt and glycogen synthase kinase 3β–dependent pathway. mol. cancer ther., 2011, 10(6):949-59.
    [2]. joyce e. ohm, michael r. shurin, clemens esche, et al. effect of vascular endothelial growth factor and flt3 ligand on dendritic cell generation in vivo. journal of immunology, 1999, 163:3260-3268.
Linifanib (ABT-869) Preparation Products And Raw materials
Raw materials
Preparation Products
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Linifanib (ABT-869) Spectrum
796967-16-3, Linifanib (ABT-869)Related Search:
  • Inhibitors
  • Growt Factors and Citokines.
  • Tyrosine Kinase Inhibitors
  • Heterocycles
  • Aromatics
  • APIs
  • 信号转导通路激酶抑制剂
  • 抑制剂
  • 生物试剂
  • 合成有机化合物配体
  • 合成材料中间体-高分子材料
  • 标准品
  • 细胞生物学试剂
  • 科研原药系列
  • 医药抑制剂
  • 杂环类
  • 抗肿瘤药物
  • 小分子抑制剂，天然产物
  • 小分子抑制剂
  • 蛋白酪氨酸激酶
  • 原料药【仅供科研】
  • 化合物LINIFANIB,10 MM DMSO 溶液
  • 利尼伐尼|||ABT-869|||RG3635|||AL-39324
  • 利尼尼布
  • 利尼尼布-D4
  • 1-(4-(3-氨基-1H-吲唑-4-基)苯基)-3-(2-氟-5-甲基苯基)脲
  • 化合物LINIFANIB
  • VEGF和PDGFR受体家族抑制剂(LINIFANIB)
  • 利尼伐尼(ABT-869)
  • N-[4-(3-氨基-1H-吲唑-4-基)苯基]-N1-(2-氟-5-甲基苯基)脲
  • 脲, N-[4-(3-氨基-1H-吲唑-4-基)苯基]-N'-(2-氟-5-甲基苯基)-
  • 利尼伐尼
  • 利尼伐尼LINIFANIB
  • N-[4-(3-氨基-1H-吲唑-4-基)苯基]-N'-(2-氟-5-甲基苯基)脲
  • 796967-16-3
  • Linifanib, 10 mM in DMSO
  • ABT-869|||RG3635|||AL-39324
  • Caswell No. 146
  • Linifanib-d4
  • Linifanib (ABT-869) USP/EP/BP
  • ABT-869;AL-39324;ABT 869;ABT869;AL 39324;AL39324;RG3635
  • 1-(4-(3-amino-1H-indol-4-yl)phenyl)-3-(2-fluoro-5-methylphenyl)urea
  • CS-178
  • ABT 869 Linifanib (ABT-869)
  • Linifanib N-[4-(3-Amino-1H-indazol-4-yl)phenyl]-N'-(2-fluoro-5-methylphenyl)urea
  • AL39324,RG3635
  • ABT-869、AL-39324
  • ABT-869(Linifanib)/AL-39324,RG3635
  • ABT-869; AL-39324; RG3635
  • LINIFANIB ABT-869
  • Urea, N-[4-(3-aMino-1H-indazol-4-yl)phenyl]-N'-(2-fluoro-5-Methylphenyl)-nifanib
  • ABT-869
  • ABT-869/Linifanib
  • RG3635
  • AL-39324
  • ABT-869 5.2G
  • Urea, N-(4-(3-amino-1H-indazol-4-yl)phenyl)-N'-(2-fluoro-5-methylphenyl)-
  • N-(4-(3-Amino-1H-indazol-4-yl)phenyl)-N1-(2-fluoro-5-methylphenyl)urea

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