ChemicalBook > CAS DataBase List > 1H-Pyrazole-3-acetamide, 5-[[7-[3-[ethyl(2-hydroxyethyl)amino]propoxy]-4-quinazolinyl]amino]-N-(3-fluorophenyl)-

1H-Pyrazole-3-acetamide, 5-[[7-[3-[ethyl(2-hydroxyethyl)amino]propoxy]-4-quinazolinyl]amino]-N-(3-fluorophenyl)-

1H-Pyrazole-3-acetamide, 5-[[7-[3-[ethyl(2-hydroxyethyl)amino]propoxy]-4-quinazolinyl]amino]-N-(3-fluorophenyl)- Structure
1H-Pyrazole-3-acetamide, 5-[[7-[3-[ethyl(2-hydroxyethyl)amino]propoxy]-4-quinazolinyl]amino]-N-(3-fluorophenyl)-
  • CAS No.722544-51-6
  • Chemical Name:1H-Pyrazole-3-acetamide, 5-[[7-[3-[ethyl(2-hydroxyethyl)amino]propoxy]-4-quinazolinyl]amino]-N-(3-fluorophenyl)-
  • CBNumber:CB01512456
  • Molecular Formula:C26H30FN7O3
  • Formula Weight:507.56
  • MOL File:722544-51-6.mol
1H-Pyrazole-3-acetamide, 5-[[7-[3-[ethyl(2-hydroxyethyl)amino]propoxy]-4-quinazolinyl]amino]-N-(3-fluorophenyl)- Property
  • Boiling point 796.7±60.0 °C(Predicted)
  • Density 1.359±0.06 g/cm3(Predicted)
  • storage temp. 2-8°C
  • solubility DMSO: >15mg/mL
  • pka 13.07±0.10(Predicted)
  • form powder
  • color white to beige
  • Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
  • InChIKey QYZOGCMHVIGURT-UHFFFAOYSA-N
  • CAS DataBase Reference 722544-51-6
  • FDA UNII 29P8LWS24N
  • NCI Drug Dictionary barasertib
  • UNSPSC Code 12352200
  • NACRES NA.77
Safety
  • WGK Germany  :3
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302
  • Precautionary statements P280-P305+P351+P338
1H-Pyrazole-3-acetamide, 5-[[7-[3-[ethyl(2-hydroxyethyl)amino]propoxy]-4-quinazolinyl]amino]-N-(3-fluorophenyl)- Price More Price(2)
  • Brand: Sigma-Aldrich(India)
  • Product number: SML0268
  • Product name : AZD1152-HQPA
  • Purity: ≥98% (HPLC)
  • Packaging: 10MG
  • Price: ₹11677.2
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: SML0268
  • Product name : AZD1152-HQPA
  • Purity: ≥98% (HPLC)
  • Packaging: 50MG
  • Price: ₹47208.3
  • Updated: 2022/06/14
  • Buy: Buy

1H-Pyrazole-3-acetamide, 5-[[7-[3-[ethyl(2-hydroxyethyl)amino]propoxy]-4-quinazolinyl]amino]-N-(3-fluorophenyl)- Chemical Properties,Usage,Production

  • Description AZD1152-HQPA (722544-51-6) is a potent and highly selective inhibitor of Aurora B.1?Aurora B Ki?= 0.36 nM; Aurora A Ki?= 1,369 nM.2?It inhibits the growth of tumors in multiple cancer models.3-6?Excessive ROS generation7?and upregulated tumor suppressor miRNAs8?have been proposed as a novel mechanisms of cytotoxicity of AZD1152-HQPA.
  • Uses AZD1152-HQPA has been used:
    • for the dose dependent inhibition of aurora kinase B (AURKB)
    • as a component to identify that, replication timing regulatory factor 1 (RIF1) and protein phosphatase 1 (PP1) are critical for the regulation of abscission timing in human cells
    • as a component to study the relevance of AURKB as a cancer therapeutic target

  • Uses AZD1152-HQPA is a a highly selective inhibitor of aurora-B kinase. AZD1152-HQPA has been shown to inhibit osteosarcoma cell line U2-OS cells proliferation. AZD1152-HQPA was also shown to be an effective apoptosis-inducing agent in acute myeloid leukemia cell lines and primary acute myeloid leukemia cultures.
  • Definition ChEBI: AZD-1152 is a member of the of quinazolines that is 4-aminoquinazolin-7-ol in which the amino group at position 4 has been substituted by a 5-[2-(3-fluoroanilino)-2-oxoethyl]-1H-pyrazol-3-yl group, while the hydroxy group at position 7 has been converted into the corresponding 3-[ethyl(2-hydroxyethyl)aminopropyl ether. It has a role as an antineoplastic agent and an Aurora kinase inhibitor. It is a member of quinazolines, a secondary carboxamide, a tertiary amino compound, a secondary amino compound, a member of pyrazoles, a primary alcohol, a member of monofluorobenzenes and an anilide.
  • Biochem/physiol Actions AZD1152-HQPA is the active metabolite of AZD-1152, a potent selective Aurora Kinase B inhibitor. AZD1152 is 50-fold selective for Aurora kinase B over Aurora kinase C and over 1000-fold selective for Aurora kinase B over Aurora Kinase A. (IC50s: aurora-A, 1,369 nmol/L; aurora-B, 0.36 nmol/L; aurora-C, 17.0 nmol/L). It is converted in plasma to the active form AZD1152-HQPA, which has been shown to have antineoplastic activity in a variety of animal models and human cancer cell lines.
  • target Aurora B
  • References 1) Mortlock?et al. (2007)?Discovery, Synthesis, and in Vivo Activity of a New Class of Pyrazoloquinazolines as Selective Inhibitors of Aurora B Kinase; J. Med. Chem.?50?2213 2) Wilkinson?et al.?(2007)?AZD1152, a Selective Inhibitor of Aurora B Kinase, Inhibits Human Tumor Xenograft Growth by Inducing Apoptosis; Clin. Cancer Res.?13?3682 3) Oke?et al.?(2009)?AZD1152 rapidly and negatively affects the growth and survival of human acute myeloid leukemia cells in vitro and in vivo; Cancer Res.?69?4150 4) Aihara?et al.?(2010)?The selective Aurora B kinase inhibitor AZD1152 as a novel treatment for hepatocellular carcinoma; J. Hepatol.?52?63 5) Mori?et al.?(2011)?Effects of AZD1152, a selective Aurora B kinase inhibitor of Burkitt’s and Hodgkin’s lymphomas; Biochem. Pharmacol.?82?1252 6) Helfrich?et al.?(2016)?Barasertib (AZD1152), a Small Molecule Aurora B Inhibitor, Inhibits the Growth of SCLC Cell Lines In Vitro and In Vivo; Mol. Cancer Ther.?15?2314 7) Zekri?et al.?(2017)?Reactive oxygen species generation and increase in mitochondrial copy number: new insight into the potential mechanism of cytotoxicity induced by aurora kinase inhibitor, AZD1152-HQPA; Anticancer Drugs?28?841 8) Zekri?et al.?(2018)?The Potential Contribution of microRNAs in Anti-cancer Effects of Aurora Kinase Inhibitor (AZD1152-HQPA); J. Mol. Neurosci.?65?444
1H-Pyrazole-3-acetamide, 5-[[7-[3-[ethyl(2-hydroxyethyl)amino]propoxy]-4-quinazolinyl]amino]-N-(3-fluorophenyl)- Preparation Products And Raw materials
Raw materials
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1H-Pyrazole-3-acetamide, 5-[[7-[3-[ethyl(2-hydroxyethyl)amino]propoxy]-4-quinazolinyl]amino]-N-(3-fluorophenyl)- Spectrum
722544-51-6, 1H-Pyrazole-3-acetamide, 5-[[7-[3-[ethyl(2-hydroxyethyl)amino]propoxy]-4-quinazolinyl]amino]-N-(3-fluorophenyl)-Related Search:
  • Inhibitor
  • API intermediates
  • Protein Kinase Inhibitors and Activators
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • Heterocycles
  • Aromatics
  • Inhibitors
  • 信号转导通路激酶抑制剂
  • 合成有机化合物配体
  • 抑制剂
  • 细胞生物学试剂
  • 小分子抑制剂，天然产物
  • 小分子抑制剂
  • 细胞周期
  • 医药中间体
  • C26H30FN7O3
  • AZD-1152;AZD-1152-HQPA;AZD-1152-HYDROXYQPA;AZD-2811
  • 化合物BARASERTIB,10 MM DMSO 溶液
  • AZD1152-HQPA,AURORA B KINASE抑制剂
  • BARASERTIB (AZD1152-HQPA),AURORA B激酶抑制剂
  • 2-(5-((7-(3-(乙基(2-羟乙基)氨基)丙氧基)喹唑啉-4-基)氨基)-1H-吡唑-3-基)-N-(3-氟苯基)乙酰胺
  • 巴拉塞替 (AZD1152-HQPA)
  • 化合物BARASERTIB
  • AURORA B抑制剂(AZD1152-HQPA)
  • 巴拉塞替-HQPA
  • 5-[[7-[3-[乙基(2-羟基乙基)氨基]丙氧基]-4-喹唑啉]氨基]-N-(3-氟苯基)-1H-吡唑-3-乙酰胺
  • 722544-51-6
  • AZD-1152-hydroxyQPA
  • Barasertib-HQPA, 10 mM in DMSO
  • AZD1152-HQPA, Aurora B kinase inhibitor
  • Defosbarasertib
  • AZD1152-HQPA Aurora B kinase inhibitor ab142049
  • AZD-1152HQPA
  • AZD1152-HQPA
  • AZD-2811
  • Barasertib (AZD1152-HQPA)
  • Barasertib
  • Barasertib (AZD1152-HQPA|AZD2811)
  • Barasertib ( INH-34
  • 1H-Pyrazole-3-acetamide, 5-[[7-[3-[ethyl(2-hydroxyethyl)amino]propoxy]-4-quinazolinyl]amino]-N-(3-fluorophenyl)- USP/EP/BP
  • AZD1152-HQPA|AZD2811
  • 1H-Pyrazole-3-acetamide
  • AZD1152-HQPA;BARASERTIB;AZD1152;AZD 1152;INH 34
  • Barasertib-HQPA
  • AZD1152; AZD-1152
  • CS-41
  • AZD-2811; AZD 2811; AZD2811; AZD-1152HQPA; AZD 1152HQPA; AZD1152HQPA; AZD1152 HQPA; AZD1152-HQPA; AZD1152HQPA.
  • 2-(5-((7-(3-(Ethyl(2-hydroxyethyl)amino)propoxy)quinazolin-4-yl)amino)-1H-pyrazol-3-yl)-N-(3-f
  • BARASERTIB (AZD1152-HQPA);AZD1152; AZD 1152
  • Barasertib, >=98%
  • 3-[[7-[3-[Ethyl(2-hydroxyethyl)amino]propoxy]-4-quinazolinyl]amino]-N-(3-fluorophenyl)-1H-pyrazole-5-acetamide
  • AZD1152-HQPA 5-[[7-[3-[Ethyl(2-hydroxyethyl)amino]propoxy]-4-quinazolinyl]amino]-N-(3-fluorophenyl)-1H-pyrazole-3-acetamide
  • 5-[[7-[3-[Ethyl(2-hydroxyethyl)amino]propoxy]-4-quinazolinyl]amino]-N-(3-fluorophenyl)-1H-pyrazole-3-acetamide AZD1152-HQPA
  • 2-(5-(7-(3-(ethyl(2-hydroxyethyl)amino)propoxy)quinazolin-4-ylamino)-1H-pyrazol-3-yl)-N-(3-fluorophenyl)acetamide
  • AZD1152 HPQA
  • 2-[5-(7-{3-[ETHYL-(2-HYDROXY-ETHYL)-AMINO]-PROPOXY}-QUINAZOLIN-4-YLAMINO)-2H-PYRAZOL-3-YL]-N-(3-FLUORO-PHENYL)-ACETAMIDE
  • 1H-Pyrazole-3-acetamide, 5-[[7-[3-[ethyl(2-hydroxyethyl)amino]propoxy]-4-quinazolinyl]amino]-N-(3-fluorophenyl)-

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