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MG-132

CAS No.133407-82-6
Chemical Name:MG-132
CBNumber:CB3298042
Molecular Formula:C26H41N3O5
Formula Weight:475.62
MOL File:133407-82-6.mol

MG-132 Property

Melting point 80-84℃ (DEC.)
alpha -61～-67°
Boiling point 682.0±55.0 °C(Predicted)
Density 1.073
Flash point 366℃
storage temp. -20°C
solubility methanol: 1 mg/mL
form solid film
pka 11.14±0.46(Predicted)
color White
Water Solubility Soluble in ethanol, chloroform, methanol, water.
Stability Stable for 2 years from date of purchase as supplied. Solutions in DMSO, DMF or ethanol may be stored at -20° for up to 1 week.
InChIKey TZYWCYJVHRLUCT-VABKMULXSA-N
FDA UNII RF1P63GW3K
UNSPSC Code 12352209
NACRES NA.77

Safety

Risk Statements :36/37/38
Safety Statements :24/25
WGK Germany :3
HS Code :29242990

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H315-H319-H335
Precautionary statements P271-P280

MG-132 Price More Price(8)

Brand: Sigma-Aldrich(India)
Product number: 474790
Product name : MG-132 - CAS 133407-82-6 - Calbiochem
Purity: A cell-permeable, potent, reversible proteasome inhibitor (Ki = 4 nM).
Packaging: 1MG
Price: ₹6600.01
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: 474791
Product name : InSolution MG-132 - CAS 133407-82-6 - Calbiochem
Purity: InSolution MG-132, CAS 133407-82-6, is provided as a 10 mM solution in DMSO. Acts as a potent, reversible proteasome inhibitor (Ki = 4 nM).
Packaging: 1MG
Price: ₹8890
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: C2211
Product name : Z-Leu-Leu-Leu-al
Purity: ≥90% (HPLC)
Packaging: 5MG
Price: ₹18175.18
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: 474791
Product name : InSolution MG-132 - CAS 133407-82-6 - Calbiochem
Purity: InSolution MG-132, CAS 133407-82-6, is provided as a 10 mM solution in DMSO. Acts as a potent, reversible proteasome inhibitor (Ki = 4 nM).
Packaging: 5MG
Price: ₹23839.99
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: 474790
Product name : MG-132 - CAS 133407-82-6 - Calbiochem
Purity: A cell-permeable, potent, reversible proteasome inhibitor (Ki = 4 nM).
Packaging: 5MG
Price: ₹17760.01
Updated: 2022/06/14
Buy: Buy

MG-132 Chemical Properties,Usage,Production

Description MG-132 (133407-82-6) is a specific inhibitor of the chymotrypsin-like activity of the 20S proteasome (IC50=100 nM with Z-LLL-AMC as substrate).1 Also inhibits calpain (IC50=1.25 μM).1 Suppresses gastric cancer cell proliferation and induces macro-autophagy.2 Activates stress kinases and induces Hsp72.3 Induces neurite outgrowth.1 MG-132 blocks NFκB activation by blocking IκB proteolysis (IC50=3 μM).4 Cell permeable.
Uses MG 132 is a potent, membrane-permeable proteasome inhibitor. It induces neurite outgrowth in PC12 cells. Neuroprotective product.
Uses A proteasome and NF-κB inhibitor.
Definition ChEBI: A tripeptide that is L-leucyl-L-leucyl-L-leucine in which the C-terminal carboxy group has been reduced to the corresponding aldehyde and the N-terminal amino group is protected as its benzyloxycarbonyl derivative.
General Description Potent, reversible, and cell-permeable proteasome inhibitor (K_i = 4 nM). Reduces the degradation of ubiquitin-conjugated proteins in mammalian cells and permeable stains of yeast by the 26S complex without affecting its ATPase or isopeptidase activities. Activates c-Jun N-terminal kinase (JNK1) and inhibits NF-κB activation (IC₅₀ = 3 μM).
Biological Activity Potent cell-permeable inhibitor of proteasome (IC 50 = 100 nM) and calpain (IC 50 = 1.2 μ M). Inhibits TNF- α -induced NF- κ B activation and I κ B α degradation. Induces neurite outgrowth in PC12 cells and has anticancer properties in vitro .
Biochem/physiol Actions Cell permeable: yes
storage -20°C (desiccate)
References 1) Tsubuki et al. (1996), Differential inhibition of calpain and proteasome activities by peptidyl aldehydes of di-leucine and tri-leucine; J. Biochem.,? 119 572 2) Wu? et al. (2010), Macroautophagy and ERK phosphorylation counteract the antiproliferative effect of proteasome inhibitor in gastric cancer cells; Autophagy, 6 228 3) Meriin? et al. (1998), Proteasome inhibitors activate stress kinases and induce Hsp72. Diverse effects on apoptosis; J. Biol. Chem., 273 6373 4) Fiedler et al. (1998), Inhibition of TNF-alpha-induced NF-kappaB activation and IL-8 release in A549 cells with the proteasome inhibitor MG-132; Am. J. Respir. Cell Mol. Biol., 19 259