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Bendazol

CAS No.621-72-7
Chemical Name:Bendazol
CBNumber:CB8176220
Molecular Formula:C14H12N2
Formula Weight:208.26
MOL File:621-72-7.mol

Bendazol Property

Melting point 187°
Boiling point 337.46°C (rough estimate)
Density 1.1345 (rough estimate)
refractive index 1.6152 (estimate)
storage temp. Sealed in dry,Room Temperature
solubility Soluble in DMSO
form Solid
pka 11.77±0.10(Predicted)
color Crystals or needles from benzene
CAS DataBase Reference 621-72-7(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII 26601THN1D

Safety

HazardClass :IRRITANT
Toxicity :LD50 orl-mus: 100 mg/kg FRZKAP (1),44,83

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H227
Precautionary statements P501-P210-P280-P370+P378-P403+P235

Bendazol Chemical Properties,Usage,Production

Uses Bendazol is an orally effective antihypertensive agent. Bendazol acts directly on vascular smooth muscle to dilate blood vessels and reduce peripheral resistance, thereby improving blood circulation. Bendazol significantly inhibits the development of myopia in rabbit models. Bendazol can regulate kidney function by increasing the activity of NO synthase in the rat model of nephrogenic hypertension. In addition, Bendazol has an effect on sexual behavior and spermatogenesis in male rats[1][2][3].
Definition ChEBI: Bendazol is a member of benzimidazoles.
Safety Profile Poison by ingestion andintraperitoneal routes. Moderately toxic by subcutaneousroute. Experimental reproductive effects. When heated todecomposition it emits toxic fumes of NOx.

in vivo

Bendazol (1%; Eye drops; Four times daily for 6 weeks) significantly inhibits the development of myopia and down-regulates the expression of HIF-1α in experimental myopia rabbit models^[1].
Bendazol (0.1 mg/kg; Intraperitoneal injection; 2 weeks) regulates kidney function by increasing the activity of NO synthase in the rat model of nephrogenic hypertension^[2].

Animal Model:	New Zealand white rabbits aged 3 weeks old with experimental myopia^[1]
Dosage:	1%
Administration:	Eye drops; Four times daily for 6 weeks
Result:	Inhibited the progression of form-deprivation myopia. Suppressed the upregulation of HIF-1α.

Animal Model:	Paraformaldehyde (HY-Y0333) treated mature random-bred male rats (250-280 g)^[2]
Dosage:	0.1 mg/kg
Administration:	Intraperitoneal injection (i.p.); 2 weeks
Result:	Remained NADPH diaphorase activity in PT epitheliocytes near the control level throughout the experiment; Gradually increased NADPH diaphorase activity in DT epitheliocytes to the control level throughout the experiment. Enhanced NADPH diaphorase activity and maintained it elevated in renal glomeruli throughout the experiment; Increased NADPH diaphorase in the collecting tubules, but thereupon it declined to the control level at the end of experimental. Insignificant enhanced of NOS activity in PT epitheliocytes observed on postinjection week 1 can somewhat contribute to upregulation of natriuresis and diuresis.

IC 50 HIF-1α
References [1] Tong L, et al. Topical bendazol inhibits experimental myopia progression and decreases the ocular accumulation of HIF-1α protein in young rabbits. Ophthalmic Physiol Opt. 2020 Sep;40(5):567-576. DOI:10.1111/opo.12717
[2] Eliseeva EV, et al. Effect of Hypotensive Drugs on Dynamics of Nitroxide-Producing Renal Function in Rats with Nephrogenic Hypertension. Bull Exp Biol Med. 2017 Jan;162(3):357-361. DOI:10.1007/s10517-017-3615-3
[3] Kuzubova EA, et al. [Effect of dibazol (bendazol) on the generative function in rats]. Eksp Klin Farmakol. 2007 Mar-Apr;70(2):37-9. PMID:17523449