Description
Phenylacetone (exempt preparation) (Item No. 16444) is an analytical reference standard categorized as a precursor in the synthesis of amphetamine and methamphetamine. Phenylacetone is regulated as a Schedule II compound in the United States. Phenylacetone (exempt preparation) (Item No. 16444) is provided as a DEA exempt preparation. This product is intended for research and forensic applications.
Chemical Properties
1-Phenyl-2-propanone is a colorless liquid with a pleasant odor; it is insoluble in water and soluble in organic solvents.
Uses
A metabolite of Lisdexamfetamine dimesylate. 1-Phenyl-2-propanone is used as an intermediate for the synthesis of pharmaceuticals, e.g., Prenylamine, a coronary vasodilator (Hoechst) .
Uses
In organic synthesis; production of benzyl radicals by photolysis.
Definition
ChEBI: Phenylacetone is a propanone that is propan-2-one substituted by a phenyl group at position 1. It is a member of propanones and a methyl ketone.
Production Methods
1-Phenyl-2-propanone is produced by catalytic ketonization of phenylacetic acid with acetic acid over an alumina-supported cerium oxide catalyst at 400 – 500℃. It may also be produced by the rearrangement of phenylpropylene oxide on zeolites or oxidation of 2-phenylpropanol.
References
[1] W KRAWCZYK. Impurity profiling/comparative analyses of samples of 1-phenyl-2-propanone.[J]. Bulletin on narcotics, 2005, 57 1-2: 33-62.
[2] A SINNEMA A M V. Impurities in illicit amphetamine: review.[J]. Bulletin on narcotics, 1981, 33 3: 37-54.
