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2-Methylbenzimidazole

CAS No.615-15-6
Chemical Name:2-Methylbenzimidazole
CBNumber:CB5439553
Molecular Formula:C8H8N2
Formula Weight:132.16
MOL File:615-15-6.mol

2-Methylbenzimidazole Property

Melting point 175-177 °C (lit.)
Boiling point 234.08°C (rough estimate)
Density 1.1083 (rough estimate)
refractive index 1.6013 (estimate)
storage temp. Sealed in dry,Room Temperature
solubility DMSO (Slightly), Methanol (Slightly)
form Crystalline Powder
pka 6.19(at 25℃)
color Light beige to brown
Water Solubility slightly soluble
BRN 112264
InChIKey LDZYRENCLPUXAX-UHFFFAOYSA-N
CAS DataBase Reference 615-15-6(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII ZH8IWW7Y8B
NIST Chemistry Reference 1H-benzimidazole, 2-methyl-(615-15-6)
EPA Substance Registry System 1H-Benzimidazole, 2-methyl- (615-15-6)
UNSPSC Code 12352100
NACRES NA.22

Safety

Hazard Codes :Xn
Risk Statements :22-37/38-41-20/21/22
Safety Statements :26-39-45-44
WGK Germany :3
RTECS :DD9100000
TSCA :Yes
HS Code :29339990

NFPA 704:

	1
2		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordDanger
Hazard statements H302-H315-H318-H335
Precautionary statements P280-P301+P312+P330-P302+P352-P305+P351+P338+P310

2-Methylbenzimidazole Price More Price(4)

Brand: Sigma-Aldrich(India)
Product number: M29800
Product name : 2-Methylbenzimidazole
Purity: 98%
Packaging: 5G
Price: ₹2100.05
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: M29800
Product name : 2-Methylbenzimidazole
Purity: 98%
Packaging: 100G
Price: ₹5239.3
Updated: 2022/06/14
Buy: Buy

Brand: TCI Chemicals (India)
Product number: M0286
Product name : 2-Methylbenzimidazole
Purity: min. 98.0 %
Packaging: 25G
Price: ₹2500
Updated: 2022/05/26
Buy: Buy

Brand: TCI Chemicals (India)
Product number: M0286
Product name : 2-Methylbenzimidazole
Purity: min. 98.0 %
Packaging: 250G
Price: ₹11300
Updated: 2022/05/26
Buy: Buy

2-Methylbenzimidazole Chemical Properties,Usage,Production

Chemical Properties light beige to brown crystalline powder. Soluble in alcohol, ether, hot water and sodium hydroxide solution, insoluble in benzene.
Uses
- 2-Methylbenzimidazole is an important pharmacophore widely used in medicinal chemistry for the synthesis of various antibacterial and antifungal agents.
- It can be used as a key precursor to synthesize substituted benzimidazo[1,2-a]quinolones.
- It can be used in the synthesis of reversible solid-to-liquid phase transition coordination polymer crystals.
- 2-Methylbenzimidazole also exhibits corrosion inhibition.
Definition ChEBI: 2-Methyl-1H-benzo[d]imidazole is a member of benzimidazoles.
Preparation 2-Methylbenzimidazole is synthesized by the condensation of o-phenylenediamine with acetic acid. The mixture of o-phenylenediamine and acetic acid is heated at 100°C for 2 hours and then cooled slowly. 10% sodium hydroxide solution is added slowly to the mixture until it is slightly alkaline. The mixture is filtered and washed with cold water. The crude product is then recrystallized with water and decolorized with activated charcoal to obtain the final product. The yield is 68%.
Synthesis Reference(s) Journal of Heterocyclic Chemistry, 26, p. 1163, 1989 DOI: 10.1002/jhet.5570260447
Chemical and Pharmaceutical Bulletin, 17, p. 1153, 1969 DOI: 10.1248/cpb.17.1153
Safety Profile Poison by intravenous route. Moderately toxic by ingestion. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.