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Benzimidazole

CAS No.51-17-2
Chemical Name:Benzimidazole
CBNumber:CB2177003
Molecular Formula:C7H6N2
Formula Weight:118.14
MOL File:51-17-2.mol

Benzimidazole Property

Melting point 169-171 °C (lit.)
Boiling point 360 °C
Density 1.1151 (rough estimate)
refractive index 1.5500 (estimate)
Flash point 360°C
storage temp. Store below +30°C.
solubility xylene: soluble1g in 2g (boiling)(lit.)
pka 5.532(at 25℃)
form Crystalline Powder or Crystals
color Beige to brown
Water Solubility sparingly soluble
λmax 271nm(MeOH)(lit.)
Merck 14,1081
BRN 109682
Stability Stable. Combustible. Incompatible with strong oxidising agents.
InChIKey HYZJCKYKOHLVJF-UHFFFAOYSA-N
LogP 1.320
CAS DataBase Reference 51-17-2(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII E24GX49LD8
NIST Chemistry Reference 1H-Benzimidazole(51-17-2)
EPA Substance Registry System Benzimidazole (51-17-2)
UNSPSC Code 12352100
NACRES NA.22

Safety

Hazard Codes :Xi
Risk Statements :36/37/38
Safety Statements :37/39-26-24/25
WGK Germany :3
RTECS :DD5425000
Hazard Note :Irritant
TSCA :Yes
HS Code :29339990
Hazardous Substances Data :51-17-2(Hazardous Substances Data)
Toxicity :LD50 oral in mouse: 2910mg/kg

NFPA 704:

	1
1		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H302
Precautionary statements P264-P270-P301+P312-P501

Benzimidazole Price More Price(14)

Brand: Sigma-Aldrich(India)
Product number: 8.21956
Product name : Benzimidazole
Purity: for synthesis
Packaging: 100G
Price: ₹5700
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: 8.21956
Product name : Benzimidazole
Purity: for synthesis
Packaging: 500G
Price: ₹18790.01
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: 194123
Product name : Benzimidazole
Purity: 98%
Packaging: 5G
Price: ₹2002.63
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: 194123
Product name : Benzimidazole
Purity: 98%
Packaging: 100G
Price: ₹2922.75
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: 194123
Product name : Benzimidazole
Purity: 98%
Packaging: 500G
Price: ₹12372.98
Updated: 2022/06/14
Buy: Buy

Benzimidazole Chemical Properties,Usage,Production

Chemical Properties white crystals
Uses Usually used as template compound in the preparation of molecularly imprinted polymer via electropolymerization and electrodeposition of pyrrole on a pencil graphite electrode,and also used in the preparation of benzimidazolium surfactant, 1-hexadecyl-1H-benzimidazole.
Uses Benzimidazole is a building block for making anthelmintic drugs like albendazole, mebendazole and triclabendazole and anti-ulcer drugs like pantoprazole, rabeprazole, lansoprazole and omeprazole. It is used in the preparation of pyrene derived benzimidazole linked polymers (BILPs), which are used for selective carbon dioxide separation applications due to their properties like porous materials, regenerability and sorbent selection parameters.
Definition ChEBI: 1H-benzimidazole is the 1H-tautomer of benzimidazole. It is a benzimidazole and a polycyclic heteroarene. It is a conjugate acid of a benzimidazolide. It is a tautomer of a 4H-benzimidazole, a 2H-benzimidazole and a 3aH-benzimidazole.
General Description White tabular crystals.
Air & Water Reactions Insoluble in water.
Reactivity Profile An amine. Neutralizes acids to form salts plus water. These acid-base reactions are exothermic. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated in combination with strong reducing agents, such as hydrides. May be shock sensitive.
Health Hazard ACUTE/CHRONIC HAZARDS: When heated to decomposition Benzimidazole emits highly toxic fumes.
Fire Hazard Flash point data for Benzimidazole are not available. Benzimidazole is probably combustible.
Pharmacology The mode of action of benzimidazoles has been described in several comprehensive reviews (1,32,33). The primary mode of action of benzimidazoles has been identified as the specific binding to the β-subunit of fungal tubulin and, consequently, an interference with microtubule assembly. Microtubules are major components of the fungal cytoskeleton and are involved in meiosis and mitosis, both of which are blocked in the presence of benzimidazoles.
Safety Profile Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion. Mutation data reported. When heated to decomposition it emits highly toxic fumes of NOx.
Purification Methods It crystallises from water or aqueous EtOH (charcoal) and is dried at 100o for 12hours. [Beilstein 23 H 131, 23/6 V 196.]