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7-Azaindole

CAS No.271-63-6
Chemical Name:7-Azaindole
CBNumber:CB1664663
Molecular Formula:C7H6N2
Formula Weight:118.14
MOL File:271-63-6.mol

7-Azaindole Property

Melting point 105-107 °C (lit.)
Boiling point 270 °C (753.1004 mmHg)
Density 1.1151 (rough estimate)
refractive index 1.5500 (estimate)
Flash point 270°C
storage temp. Sealed in dry,Room Temperature
solubility Chloroform, Methanol
pka 7.69±0.20(Predicted)
form Powder
color White to off-white
BRN 109667
InChIKey MVXVYAKCVDQRLW-UHFFFAOYSA-N
CAS DataBase Reference 271-63-6(CAS DataBase Reference)
FDA UNII QX4465NR9T
NIST Chemistry Reference 1H-Pyrrolo[2,3-b]pyridine(271-63-6)
EPA Substance Registry System 1H-Pyrrolo[2,3-b]pyridine (271-63-6)
UNSPSC Code 12352100
NACRES NA.22

Safety

Hazard Codes :Xi,Xn
Risk Statements :36-41-37/38-22
Safety Statements :39-26-36/37/39
WGK Germany :3
RTECS :UY8710000
HazardClass :IRRITANT
HS Code :29339990

NFPA 704:

	1
2		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H315-H319
Precautionary statements P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313

7-Azaindole Price More Price(7)

Brand: Sigma-Aldrich(India)
Product number: A95502
Product name : 7-Azaindole
Purity: 98%
Packaging: 1G
Price: ₹1800
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: A95502
Product name : 7-Azaindole
Purity: 98%
Packaging: 5G
Price: ₹5455.8
Updated: 2022/06/14
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Brand: TCI Chemicals (India)
Product number: P1117
Product name : 1H-Pyrrolo[2,3-b]pyridine
Purity: min. 98.0 %
Packaging: 5G
Price: ₹5100
Updated: 2022/05/26
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Brand: TCI Chemicals (India)
Product number: P1117
Product name : 1H-Pyrrolo[2,3-b]pyridine
Purity: min. 98.0 %
Packaging: 25G
Price: ₹16400
Updated: 2022/05/26
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Brand: ottokemi
Product number: A 2723
Product name : 7-Azaindole
Purity: 98%
Packaging: 1gm
Price: ₹918
Updated: 2022/05/26
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7-Azaindole Chemical Properties,Usage,Production

Description 7-Azaindole is the starting material for the synthesis of azaserotonin. Its derivatives are of great value in drug development, for example, as the backbone of protein kinase B (PKB/Akt) inhibitors. 7-Azaindole and its derivatives have a variety of biological activities, for example, 7-azatryptophan is able to inhibit the growth of tobacco and carrot cells. In addition, it also binds to the Erm enzyme (methyltransferase family), thereby conferring antibiotic resistance.
Chemical Properties Brown-Cyrstalline Solid
Uses 7-Azaindole is imidazolinone derivatives as CGRP receptor antagonists used in the treatment.
A heterocyclic molecule that can be utilized as a pharmaceutical building block.
Starting material in a recent synthesis of azaserotonin.
Application 7-Azaindole is a heterocyclic organic compound, which is an organic synthesis intermediate and a pharmaceutical intermediate. It is the core structure of many drugs, such as antitumor drugs, dopamine D4 receptors, p38 kinase inhibitors, thrombin inhibitors, etc.
Preparation Synthesis of 7-azaindole: in a single-necked flask, add 2.0 g of 2-amino-3-methylpyridine and 2.5 g of N-Methylformanilide into 40 mL of dichloromethane, and add 3.15 g of PCl with stirring under an ice-water bath. After 4 hours of reaction, the reaction system was slowly poured into 40 mL of ammonia water, and the insoluble matter was removed by suction filtration. The organic layer was separated, washed twice with water, dried over anhydrous sodium sulfate, and evaporated to dryness to obtain 2.91 g of 7-azaindole as a pale yellow solid, with a yield of 70%.
Definition ChEBI: 1H-pyrrolo[2,3-b]pyridine is a pyrrolopyridine.
Purification Methods Recrystallise it repeatedly from EtOH, then sublime it in a vacuum [Tokumura et al. J Am Chem Soc 109 1346 1987]. The N-acetate has m 65-66o (from *C6H6), and the picrate has m 232-233o (from Me2CO) [Clemo & Swan J Chem Soc 603 1945, Beilstein 23 III/IV 1105.]