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Indoline

CAS No.496-15-1
Chemical Name:Indoline
CBNumber:CB5485525
Molecular Formula:C8H9N
Formula Weight:119.16
MOL File:496-15-1.mol

Indoline Property

Melting point -21 °C
Boiling point 220-221 °C (lit.)
Density 1.063 g/mL at 25 °C (lit.)
refractive index n20/D 1.592(lit.)
Flash point 199 °F
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility 5g/l; lnsoluble in water, soluble in alcohol and oils. Poorly soluble in Propylene glycol.
form liquid (clear)
pka 5.20±0.20(Predicted)
color clear dark brown
Odor a mild, delicate, but extremely tenacious floral odor
Water Solubility 5 g/L (20 ºC)
Sensitive Light Sensitive
BRN 111915
CAS DataBase Reference 496-15-1(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII 6DPT9AB2NK
NIST Chemistry Reference 1H-Indole, 2,3-dihydro-(496-15-1)
EPA Substance Registry System 1H-Indole, 2,3-dihydro- (496-15-1)
UNSPSC Code 12352100
NACRES NA.22

Safety

Hazard Codes :Xi
Risk Statements :36/37/38
Safety Statements :23-24/25-37/39-26
WGK Germany :3
RTECS :NL6906300
Hazard Note :Irritant
TSCA :Yes
HS Code :29339990

NFPA 704:

	2
1		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H227-H302-H315-H319-H335
Precautionary statements P210e-P261-P280a-P305+P351+P338-P405-P501a

Indoline Price More Price(4)

Brand: Sigma-Aldrich(India)
Product number: I5605
Product name : Indoline
Purity: ReagentPlus?, 99%
Packaging: 25G
Price: ₹3539.78
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: I5605
Product name : Indoline
Purity: ReagentPlus?, 99%
Packaging: 100G
Price: ₹12124
Updated: 2022/06/14
Buy: Buy

Brand: TCI Chemicals (India)
Product number: I0033
Product name : Indoline
Purity: min. 98.0 %
Packaging: 25ML
Price: ₹3900
Updated: 2022/05/26
Buy: Buy

Brand: TCI Chemicals (India)
Product number: I0033
Product name : Indoline
Purity: min. 98.0 %
Packaging: 250ML
Price: ₹13700
Updated: 2022/05/26
Buy: Buy

Indoline Chemical Properties,Usage,Production

Chemical Properties ?2,3-Dihydroindole [496-15-1], indoline C8H9N, Mr 119.16, bp 229 – 230 ℃(101.3 kPa), is a colorless liquid, which is volatile in steam and soluble in diethyl ether, acetone, and benzene, but only slightly soluble in water. Indoline is obtained by hydrogenation of indole or by catalytic cyclodehydration of 2-(2-aminophenyl)ethanol. A range of pharmaceuticals, as well as fungicides and bactericides, can be produced from indoline.
Uses As an indole derivative, Indoline can be used in the preparation of various medicinal compounds such as potential α1-adrenoceptor (α1-AR) antagonists.
Uses Indole is used in perfumery and in preparing tryptophan, one of the 20 amino acids commonly found in animal proteins. It has important application in the industry of plant growth. It is used to prepare indoleacetic acid (auxin) and other plant growth substances which help the development of roots in plant. Indole and its derivatives are widely used in making perfumes, dyes, agrochemicals and medicines.
Uses Reactant for preparation of:
- Inhibitors of NOD1-Induced Nuclear Factor-κB Activation
- Sphingosine-1-phosphate 4(S1P4) receptor antagonists
- Cytotoxic cell cycle inhibitors
- 2-Aminopyridines
- PET agent for imaging of protein kinase C (PKC)
- Sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors for the management of hyperglycemia in diabetes
- α4β2-Nicotinic acetylcholine receptor-selective partial agonists
- mGlu4 positive allosteric modulators
- Bacterial biofilm inhibitors
- Serotonin 5-HT6 receptor antagonists
Definition ChEBI: Indoline is a member of indoles.
Synthesis Reference(s) Journal of the American Chemical Society, 96, p. 7812, 1974 DOI: 10.1021/ja00832a035
Synthetic Communications, 13, p. 489, 1983 DOI: 10.1080/00397918308081827
Synthesis Indolene is manufactured from (theoretically) 2 Mol. Indole plus 1 Mol. Hydroxycitronellal by condensation under heating. The proportions may vary slightly, and it is common practice to add Diethyl phthalate to the mixture prior to heating, so that the condensation product is somewhat protected against local overheating, and the finished product becomes light of color and fairly pourable at room temperature.