Ethyl 2-methylacetoacetate

Chemical Properties

clear colorless to yellow liquid

Uses

• Ethyl 2-methylacetoacetate is used as a substrate in the rhenium-catalyzed synthesis of multisubstituted aromatic compounds.
• It can be employed in the synthesis of coumarin derivatives via Pechmann condensation.
• It undergoes dehydration to yield conjugated alkynyl and allenyl esters.
• It is also used in the total synthesis of chlorotonil A, yangjinhualine A, (+)- and (?)-saudin.

Uses

Ethyl 2-methylacetoacetate is used in Japp-Klingemann reaction to prepare hydrazones from beta-keto acid and aryl diazonium salts. It is used as a precursor involved in the synthesis of ethylpyruvate phenylhydrazone via reaction with benzenediazonium chloride.