Chemical Properties
Colorless mobile liquid. Slightly soluble in water, soluble in alcohol and oils.
Uses
Diethyl methylmalonate was used to investigate the effect of direct supplementation of the medium with di-ester of methylmalonate on erythromycin fermentation in
Saccharopolyspora erythraea mutB strain.
Uses
Diethyl methylmalonate is used as intermediate for the syntheses of pharmaceuticals, e.g. non-steroidal anti-inflammatory agents with 2-acrylpropionic acid structures acrylpropionic acid structure. It is also used in the flavour and fragrance industries. Product Data Sheet
General Description
Diethyl methylmalonate reacts with 2-cyclohexenone under abnormal Michael conditions form 2-(3-oxocyclohexyl)-2-cyclohexenone. It causes the alkylation of poly(chloromethylstyrene) during pahse transfer catalysis.
Synthesis
Diethyl methylmalonate is produced by the following method:1) by condensing Ethylpropionate with Diethyloxalate, followed by heating of the reaction product. 2) from Diethylmalonate plus Sodium and Methyl iodide.
