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ALOGLIPTIN(ALOGLIPTINE, ALOGLIPTINA)

ALOGLIPTIN(ALOGLIPTINE, ALOGLIPTINA) Structure
ALOGLIPTIN(ALOGLIPTINE, ALOGLIPTINA)
  • CAS No.850649-61-5
  • Chemical Name:ALOGLIPTIN(ALOGLIPTINE, ALOGLIPTINA)
  • CBNumber:CB91011068
  • Molecular Formula:C18H21N5O2
  • Formula Weight:339.39
  • MOL File:850649-61-5.mol
ALOGLIPTIN(ALOGLIPTINE, ALOGLIPTINA) Property
  • Boiling point: :519.2±60.0 °C(Predicted)
  • Density  :1.342
  • Flash point: :267.8℃
  • pka :9.89±0.20(Predicted)
  • FDA UNII :JHC049LO86
  • NCI Drug Dictionary :alogliptin
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

ALOGLIPTIN(ALOGLIPTINE, ALOGLIPTINA) Chemical Properties,Usage,Production

  • Description Alogliptin is a dipeptidyl-peptidase IV (DPP-4) inhibitor that was approved in Japan in 2010 for treatment of type 2 diabetes, a disease in which insulin resistance and β-cell dysfunction lead to hyperglycemia. As islet function is lost, the severity of insulin resistance increases. The introduction of DPP-4 inhibitors has brought a novel class of insulinotropic agents for the treatment options available to type 2 diabetic patients. The therapeutic potential of glucagon-like peptide 1 (GLP-1), an incretin peptide, for the treatment of type 2 diabetes was realized in the 1990s. The insulinotropic effects of GLP-1 depend closely on glucose concentrations providing the possibility of glucose normalization without the risk of hypoglycemia. GLP-1 has other non-insulinotropic physiological actions that are advantageous. It suppresses glucagon secretion from a cells and slows gastric emptying, which contributes to satiety and to a slower passage and reabsorption of carbohydrates. GLP-1 also contributes to satiety via a central mechanism as a neurotransmitter with effects on the hypothalamus.
  • Chemical Properties White Solid
  • Originator Syrrx Inc. (now Takeda San Diego) (Japan)
  • Uses Alogliptin is an oral antihyperglycemic agent that is a selective inhibitor of the enzyme dipeptidyl peptidase-4 (DPP-4). Antidiabetic agent.
  • Definition ChEBI: A piperidine that is 3-methyl-2,4-dioxo-3,4-dihydropyrimidine carrying additional 2-cyanobenzyl and 3-aminopiperidin-1-yl groups at positions 1 and 2 respectively (the R-enantiomer). Used in the form of its benzoate salt for treatment of t pe 2 diabetes.
  • brand name Nesina
ALOGLIPTIN(ALOGLIPTINE, ALOGLIPTINA) Preparation Products And Raw materials
Raw materials
Preparation Products
Global(178)Suppliers
  • Supplier:
    Henan Tianfu Chemical Co.,Ltd.
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850649-61-5, ALOGLIPTIN(ALOGLIPTINE, ALOGLIPTINA)Related Search:
  • Alogliptin (SYR-322)
  • Alogliptin(free base)
  • Benzonitrile, 2-[[6-[(3R)-3-aMino-1-piperidinyl]-3,4-dihydro-3-Methyl-2,4-dioxo-1(2H)-pyriMidinyl]Methyl]-
  • Axagliptin hydrate
  • (R)-2-[6-(3-aMino-piperidin-1-yl)-3-Methyl-2,4-dioxo-3,4-dihydropyriMidin-1(2H)-yl)Methyl]-benzonitrile
  • Alogliptin Benzoate API
  • Alogliptin 2-[[6-[(3R)-3-Amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]benzonitrile
  • Trajenta
  • 850649-61-5
  • ALOGLIPTIN(ALOGLIPTINE, ALOGLIPTINA)
  • Alogliptin
  • Unii-jhc049lo86
  • 2-[[6-[(3R)-3-Amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]benzonitrile
  • ALOGLIPTIN(ALOGLIPTINE, ALOGLIPTINA)###850649-61-5
  • Trelagliptin-11
  • Alogliptin Intermediate
  • ALOGLIPTIN(ALOGLIPTINE
  • ALOGLIPTINA
  • Trelagliptin Impurity T
  • (R)-2-((6-(3-aminopiperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)benzonitri
  • Alogliptin, 99%, effective and selective DPP-4 inhibitor
  • Alogliptin,98%
  • Trelagliptin Impurity 2(Alogliptin)
  • ogL
  • 850649-61-5
  • Inhibitor
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