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TAK-438

TAK-438 Structure
TAK-438
  • CAS No.1260141-27-2
  • Chemical Name:TAK-438
  • CBNumber:CB32628441
  • Molecular Formula:C21H20FN3O6S
  • Formula Weight:461.4634032
  • MOL File:1260141-27-2.mol
TAK-438 Property
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements
TAK-438 Price More Price(4)
  • Brand: Cayman Chemical
  • Product number: 24200
  • Product name : Vonoprazan (fumarate)
  • Purity: ≥98%
  • Packaging: 500mg
  • Price: $35
  • Updated: 2021/03/22
  • Buy: Buy
  • Brand: Cayman Chemical
  • Product number: 24200
  • Product name : Vonoprazan (fumarate)
  • Purity: ≥98%
  • Packaging: 1g
  • Price: $63
  • Updated: 2021/03/22
  • Buy: Buy
  • Brand: Cayman Chemical
  • Product number: 24200
  • Product name : Vonoprazan (fumarate)
  • Purity: ≥98%
  • Packaging: 5g
  • Price: $245
  • Updated: 2021/03/22
  • Buy: Buy
  • Brand: Cayman Chemical
  • Product number: 24200
  • Product name : Vonoprazan (fumarate)
  • Purity: ≥98%
  • Packaging: 10g
  • Price: $350
  • Updated: 2021/03/22
  • Buy: Buy

TAK-438 Chemical Properties,Usage,Production

  • Description Vonoprazan fumarate (Takecab®), discovered and developed by Takeda and Otsuka, was approved by the PMDA of Japan in December 2014, and is indicated for the treatment of gastric ulcer, duodenal ulcer and reflux esophagitis. Vonoprazan fumarate has a novel mechanism of action called potassium-competitive acid blockers, which competitively inhibit the binding of potassium ions to H+, K+-ATPase (also known as the proton pump) in the final step of gastric acid secretion in gastric parietal cells. Vonoprazan does not inhibit Na+, K+-ATPase activity even at concentrations 500 times higher than that of their IC50 values against gastric H+, K+-ATPase activity. Furthermore, the drug is unaffected by the gastric secretory state, unlike PPIs.
  • Chemical Synthesis Commercially available 2-fluoroacetophenone (283) was brominated to yield a-bromo-acetophenone derivative 284. This compound was treated with ethyl 2-cyanoacetate (285) under basic conditions to provide ketoester 286 in essentially quantitative yield. Next, intramolecular condensation of 286 upon treatment of 4 M HCl furnished the tri-substituted pyrrole 287 in 53% yield. Reduction of the chloride under hydrogenolytic conditions facilitated arrival at pyrrole 288, albeit in just 18% yield. Subsequent diisobutylaluminium hydride (DIBAL) reduction, followed by the oxidation with tetrapropylammonium perruthenate (TPAP) and 4-methylmorpholine N-oxide (NMMO) afforded the corresponding aldehyde 290 in 60% yield across the 2 steps. Next, N-pyrrole substitution with pyridine- 3-sulfonyl chloride 291 gave rise to N-sulfonylpyrrole 292 in 82% yield. Reductive amination of 292 afforded amine 293, which was treated with fumaric acid (294) via co-crystallization to provide vonoprazan fumarate (XXXVI) in 74% for the two steps.

TAK-438 Preparation Products And Raw materials
Raw materials
Preparation Products
Global(290)Suppliers
  • Supplier:
    CE Pharm Co.,Ltd
  • Tel:+86 13816833708
  • Fax:
  • Email:binbin.lin@cepharm.cn
  • Country:CHINA
  • ProdList:52
  • Advantage:58
  • Supplier:
    Henan Tianfu Chemical Co.,Ltd.
  • Tel:0371-55170693
  • Fax:0371-55170693
  • Email:info@tianfuchem.com
  • Country:CHINA
  • ProdList:22607
  • Advantage:55
  • Supplier:
    Hangzhou FandaChem Co.,Ltd.
  • Tel:008615858145714
  • Fax:+86-571-56059825
  • Email:fandachem@gmail.com
  • Country:CHINA
  • ProdList:8882
  • Advantage:55
  • Supplier:
    ATK CHEMICAL COMPANY LIMITED
  • Tel:+86 21 5161 9050/ 5187 7795
  • Fax:+86 21 5161 9052/ 5187 7796
  • Email:ivan@atkchemical.com
  • Country:CHINA
  • ProdList:26734
  • Advantage:60
  • Supplier:
    career henan chemical co
  • Tel:+86-371-86658258
  • Fax:
  • Email:sales@coreychem.com
  • Country:CHINA
  • ProdList:29960
  • Advantage:58
  • Supplier:
    Biochempartner
  • Tel:0086-13720134139
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  • Email:candy@biochempartner.com
  • Country:CHINA
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  • Supplier:
    GIHI CHEMICALS CO.,LIMITED
  • Tel:08657186217390
  • Fax:
  • Email:sales@gihichemicals.com
  • Country:CHINA
  • ProdList:310
  • Advantage:58
  • Supplier:
    Hangzhou Cyanochem Co., Ltd.
  • Tel:+86 17788583750
  • Fax:+86 571 85220831
  • Email:sales@cyanochem.com
  • Country:CHINA
  • ProdList:284
  • Advantage:58
1260141-27-2, TAK-438Related Search:
  • Vonaprazan
  • 5-(2-Fluorophenyl)-N-methyl-1-(3-pyridinylsulfonyl)-1H-pyrrole-3-methanamine 2-butenedioate (Vonoprazan)
  • 1-[5-(2-fluorophenyl)-1-pyridin-3-ylsulfonylpyrrol-3-yl]-N-methylmethanamine
  • AK-438
  • Vonaprazan(TAK-438)
  • vonoprazan(tak-438)
  • Vonoprazan fumarate(TAK-438)
  • vonoprazan(tak-438)1260141-27-2
  • fuMarate vonoprazan
  • 1H-Pyrrole-3-methanamine, 5-(2-fluorophenyl)-N-methyl-1-(3-pyridinylsulfonyl)-, 2-butenedioate (1:1)
  • 5-(2-Fluorophenyl)-N-methyl-1-(3-pyridinylsulfonyl)-1H-pyrrole-3-methanamine 2-butenedioate TAK 438
  • vonaprazan(TK-438)
  • 1-[5-(2-fluorophenyl)-1-pyridin-3-ylsulfonylpyrrol-3-yl]-N-methylmethanamine,(E)-4-oxopent-2-enoic acid
  • TAK-438 Vonoprazan fumarate
  • Vonolazan Fumarate API
  • VONOPRAZAN FUMARATE (TAK-438);TAK-438
  • TAK 438,Vonoprazan
  • TAK-438
  • 1-(5-(2-FLUOROPHENYL)-1-(PYRIDIN-4-YLSULFONYL)-1H-PYRROL-3-YL)-N-METHYLMETHANAMINE
  • Vonoprazan FuMarate
  • 5-(2-Fluorophenyl)-N-methyl-1-(3-pyridinylsulfonyl)-1H-pyrrole-3-methanamine 2-butenedioate
  • Vonoprazan-025-Salt2
  • Vonoprazon Fumarate
  • TAK 438; TAK438
  • CS-597
  • Wonarazan Fumarate
  • 5-(2-Fluorophenyl)-N-methyl-1-(3-pyridinylsulfonyl)-1H-pyrrole-3-methanamine 2-butenedioate (Vonoprazan fumarate)
  • Vonoprazan fandachem
  • Vonoprazan Fumarate fandachem
  • TAK-438,1260141-27-2 Fluorine Prazan
  • TAK-438 USP/EP/BP
  • TAK-438 ISO 9001:2015 REACH
  • Vonoprazan Fumarate DISCONTINUED PLEASE SEE V767013
  • Vonoprazan fumarate API
  • Vonorasen fumarate
  • Vonoprazan Vonoprazan onoprazan Vonoprazan fumarate
  • 1260141-27-2
  • 88168-00-2
  • 260141-27-2
  • C17H16FN3O2SC4H4O4
  • Vonoprazan
  • Inhibitors
  • API