Manufacturing Process
2.6 grams magnesium, activated by means of iodine, is introduced into 20 cc
of absolute ether and is caused to react with 0.6 cc of ethyl
omide. While
warming gently, 16.2 grams (0.1 mol) of N-[1-chloropropyl-(3)]-piperidine in
40 cc of absolute ether are added and, after adding a further 0.5 cc of ethyl
omide, 14.5 grams (0.08 mol) of benzophenone in 50 cc of anhydrous ether
are added in portions. The magnesium is used up fairly quickly and, after 10
hours, only traces are left. In working up, both with hydrochloric acid and with
ammonium chloride, the hydrochloride of diphenyl-3-piperidinopropyl carbinol
is precipitated as a dense precipitate. It is purified by recrystallization from
chloroform-ethyl acetate. MP 212-214°C.
