Description
Nicotinamide N-oxide is a metabolite of nicotinamide . It is formed
via oxidation of nicotinamide by the cytochrome P450 (CYP) isoform CYP2E1. Nicotinamide N-oxide (30 mM) inhibits proliferation and induces reduction of nitroblue tetrazolium (NBT; ), indicating cell differentiation, in HL-60 promyelocytic leukemia cells. Urine levels of nicotinamide N-oxide are elevated in a mouse model of high-fat diet-induced obesity.
Chemical Properties
WHITE TO SLIGHTLY YELLOW FLUFFY CRYST. NEEDLES
Uses
A metabolite of Nicotinamide.
Definition
ChEBI: Nicotinamide N-oxide is a member of pyridines.
References
[1] ALEXANDER MICHAEL REAL P P Shangyu Hong. Nicotinamide N-oxidation by CYP2E1 in human liver microsomes.[J]. Drug Metabolism and Disposition, 2013, 41 3: 550-553. DOI:
10.1124/dmd.112.049734[2] KEIKO IWATA. Induction of differentiation in human promyelocytic leukemia HL-60 cell line by niacin-related compounds.[J]. Bioscience, Biotechnology, and Biochemistry, 2003, 67 5: 1132-1135. DOI:
10.1271/bbb.67.1132[3] JEE-YOUN JUNG. 1H NMR-based metabolite profiling of diet-induced obesity in a mouse mode.[J]. BMB Reports, 2012, 45 7: 419-424. DOI:
10.5483/bmbrep.2012.45.7.248
